Antimicrobial, antioxidant and wound healing activities of methanol leaf extract of Bridelia micrantha (Hochst.) Baill.

Asumang, Philip; Boakye, Yaw Duah; Agana, Theresa Appiah; Jibira, Yakubu; Entsie, Philomena; Akanwariwiak, William Gariba; Adu, Francis; Agyare, Christian

doi:10.1016/j.sciaf.2021.e00980

Cited by 15 publications

(15 citation statements)

References 26 publications

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“…33 Furthermore, antioxidant and antibacterial properties of saponins could assist faster wound healing. 34 Other than saponins, flavonoids have been reported to increase collagen secretion and consequently induce tissue granulation. 13 Studies also prove that flavonoids have anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

“…37 Astringent causes reduced mucosal permeability, leading to stronger bonds between the mucosa which inhibits the entrance of microorganisms and irritant chemicals. 34,38 Furthermore, tannins are reported to be capable of inhibiting hypersecretion of mucosal fluid and neutralizing inflammatory proteins. 39 Tannin compounds promote antibacterial activities by hampering the permeability the bacterial cell wall.…”

Section: Discussionmentioning

confidence: 99%

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Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

et al. 2022

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Background: Phytomedicines are gaining a spotlight in wound management, where much research has suggested the wound healing potential of Barringtonia racemosa. The objective of this study was to investigate the effectiveness of B. racemosa kernel extract in accelerating wound healing process in animal models. Methods: B. racemosa kernel was extracted using ethanol:water (7:3) solvent and was then used as a bioactive ingredient in a Carbopol 940-based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). A 3 cm diameter wound was made in the dorsal area of Rattus norvegicus rat and wound healing process was assessed up to 12 days using DESIGN (Depth, Exudate, Size of Inflammation/Infection, Granulation tissue, and Necrotic tissue) scoring system. Results: Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3rd day onward suggesting B. racemosa extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of B. racemosa kernel extract had faster wound healing than that treated with topical Metcovazin. Conclusion: B. racemosa kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 36 Furthermore, antioxidant and antibacterial properties of saponins could assist faster wound healing. 37 Other than saponins, flavonoids have been reported to increase collagen secretion and consequently induce tissue granulation. 13 Studies also prove that flavonoids have anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

“… 40 Astringent causes reduced mucosal permeability, leading to stronger bonds between the mucosa which inhibits the entrance of microorganisms and irritant chemicals. 37 , 41 Furthermore, tannins are reported to be capable of inhibiting hypersecretion of mucosal fluid and neutralizing inflammatory proteins. 42 Tannin compounds promote antibacterial activities by hampering the permeability the bacterial cell wall.…”

Section: Discussionmentioning

confidence: 99%

Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

et al. 2022

View full text Add to dashboard Cite

Background: Phytomedicines are gaining a spotlight in wound management, where much research has suggested the wound healing potential of Barringtonia racemosa. The objective of this study was to investigate the effectiveness of B. racemosa kernel extract in accelerating wound healing process in animal models. Methods: B. racemosa kernel was extracted using ethanol:water (7:3) solvent and was then used as a bioactive ingredient in a Carbopol 940-based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). A 3 cm diameter wound was made in the dorsal area of Rattus norvegicus rat and wound healing process was assessed up to 12 days using DESIGN (Depth, Exudate, Size of Inflammation/Infection, Granulation tissue, and Necrotic tissue) scoring system. Results: Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3rdday onward suggesting B. racemosa extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of B. racemosa kernel extract had faster wound healing than that treated with topical Metcovazin. On day 6, macroscopic observation on 7 ppm group revealed that the wound had persistent redness, lesion area of < 3 cm2, and 80% healthy granulation, where presence of exudate and redness were not observable. Conclusion: B. racemosa kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process.

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“…It significantly offered many advantages such as reduction of risk of heart disease and certain cancers. [3] To date, one of the most important chemical reagents for antioxidant activity was typically referred to 4HB, commonly known as monohydroxybenzoic acid. This compound was defined as a phenolic derivative of benzoic acid.…”

Section: Introductionmentioning

confidence: 99%

Release Characteristic and Antioxidant Activity of 4‐Hydroxybenzoic Acid (4HB) from Sodium Alginate and Polyvinyl Alcohol‐based Hydrogel

et al. 2022

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1, 3 and 5 %wt of 4‐hydroxybenzoic acid (4HB) was successfully loaded into sodium alginate and polyvinyl alcohol‐based hydrogel composite for enhancement of antioxidant activities. Hydrogel was prepared by freeze thaw technique. No crosslinking agents were employed. Fourier transform infrared and X‐ray diffraction technique revealed that no significant change of functional group and crystallinity was observed when 4HB was loaded. By using freeze thaw technique, microstructural properties were well packed as reported by scanning electron microscope. Due to small amount of 4‐hydroxybenzoic acid, thermal characteristic was presented in the similar feature compare to pristine hydrogel. Differential scanning calorimetry exhibited that the glass transition and melting temperatures were reported to be 90 °C and 225 °C, respectively. However, tensile strength was slightly reduced by loading 4HB. The swelling behavior was very rapidly increased at the initial stage and then it was stable. Antioxidant activities were observed by means of DPPH assay. It was important to note that 4HB loaded into sodium alginate and polyvinyl alcohol‐based hydrogel exhibited outstanding properties to be candidate as food additives to help prevent food deterioration.

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Antimicrobial, antioxidant and wound healing activities of methanol leaf extract of Bridelia micrantha (Hochst.) Baill.

Cited by 15 publications

References 26 publications

Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

Release Characteristic and Antioxidant Activity of 4‐Hydroxybenzoic Acid (4HB) from Sodium Alginate and Polyvinyl Alcohol‐based Hydrogel

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