Antimicrobial, antioxidant and antileishmanial activities of Ziziphus lotus leaves

Hammi, Khaoula Mkadmini; Khadraoui, Nadine; Ksouri, Riadh; Majdoub, Hatem; Tabbene, Olfa

doi:10.1007/s00203-021-02733-5

Cited by 12 publications

(6 citation statements)

References 67 publications

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“…This result can related to which Gram-negative bacteria contain an outer membrane (lipopolysaccharide and lipoprotein) that acts as a barrier against biomolecules. [27,28] The current study shows that the leaves have higher phenolic constituents than flower ones. Furthermore, various studies have shown that polyphenols display antibacterial activity against various bacteria.…”

Section: Antibacterial Activity Of Leaf and Flower Extracts Of J Turcicamentioning

confidence: 52%

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Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica

Bahadır Semerci,

Yıldırım,

Oztay

et al. 2023

Chemistry & Biodiversity

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The fatty acid profile, antioxidant/antibacterial, and cytotoxic effects of the extracts obtained from Jurinea turcica B.Doğan& A.Duran have been evaluated for the first time in the current study. The fatty acid profile of ethanolic extracts was determined using the Soxhlet extractor by a gas chromatography‐mass spectrometer. The antioxidant and antibacterial activities were measured by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and ferrous reduction tests and the disc diffusion technique. Additionally, the cytotoxicity and wound healing assays were performed on A549 cells. The highest amount of component in the leaf extract was docosanoic acid methyl ester, whereas abundant arachidonic acid methyl ester was mainly found in the flower extract. The IC50 values, the 50 % scavenging value for the DPPH radical, were 179.13 and 124.67 μg/mL for the leaf and flower extracts, respectively. IC50 values (the half‐maximal inhibitory concentration) were 10.4 and 24.7 μg/mL for the flower and leaf extracts, respectively. The leaf extract showed more potent antibacterial activity on Enterococcus faecalis (17 mm) and Staphylococcus aureus (16 mm) bacteria than the flower extract. In conclusion, the extracts of J. turcica have anti‐cancerogenic and antibacterial effects. Leaf extracts have antibacterial and anti‐metastatic effects, while flower extracts show antioxidant, cytotoxic, and apoptotic properties in A549 cells.

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Section: Antibacterial Activity Of Leaf and Flower Extracts Of J Turcicamentioning

confidence: 52%

“…We noted that the leaf and flower extracts of J. turcica have no antibacterial effect on gram‐negative E. coli . This result can related to which Gram‐negative bacteria contain an outer membrane (lipopolysaccharide and lipoprotein) that acts as a barrier against biomolecules [27,28] …”

Section: Resultsmentioning

confidence: 99%

Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica

Bahadır Semerci,

Yıldırım,

Oztay

et al. 2023

Chemistry & Biodiversity

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“…The chemical constituents of lotus leave mainly include alkaloids, flavonoids, polyphenolic acids, volatile oil, and so on [3]. The flavonoids from lotus leaves have been reported to regulate blood lipids [4], have antibacterial [5] and antioxidant [6] properties, inhibit atherosclerosis [7], and improve liver damage [8].…”

Section: Introductionmentioning

confidence: 99%

Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity

Yang

Yan

et al. 2023

Separations

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Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective development and utilization of lotus leaves. The deep eutectic solvents (DESs) with the highest yield of flavonoids and polyphenols were screened out from 19 different NDES combinations. The response surface method was employed to optimize the extraction process. After a rational design, a lactic acid/glycerol (molar ratio 1:2) DES was chosen as the optimal extraction solvent, and the optimum extraction parameters were as follow: water content (29%), liquid–solid ratio (37:1 mL/g), extraction time (61 min), and extraction temperature (53 °C). Compared with traditional water extraction or ethanol extraction, it improved the yield of flavonoids (126.10 mg/g) and polyphenols (126.10 mg/g). By LC–MS analysis, 19 flavonoids or organic acid compounds with known compound structural formulae were identified in the DES extract of lotus leaves. By comparing the free radical scavenging ability and total reducing ability, the extraction of lotus leaves using the NDES method was superior to both ethanol extraction and water extraction. It is a green, environmentally friendly, and efficient extraction method for antioxidants from leaves of Nelumbo nucifera Gaertn.

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“…In some countries, Z. mauritiana treats wounds, asthma, diarrhea, fever, abscesses, and swelling (Mishra et al 2011;Nyanga et al 2013;Delphine et al 2017;Moeini et al 2020;Shady et al 2022). Scientific studies have shown that the Z. mauritiana plant contains compounds that act as an antioxidant (Dahiru and Obidoa 2007;Bhatia and Mishra 2009;Gupta 2018), antimicrobial and antileishmanial (Abalaka et al 2010;Hammi et al 2022), and antidiabetic (Jarald et al 2009). The compound from the Z. mauritiana plant is also reported to have the ability to suppress the development of cancer cells (Zazouli et al 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The use of Z. mauritiana continues to grow as scientific evidence demonstrates diverse bioactive ingredients of the plants (Dahiru and Obidoa 2007;Bhatia and Mishra 2009;Jarald et al 2009;Delphine et al 2017;Askur and Ganning 2021;Hammi et al 2022;Zazouli et al 2022). Most of the analyses reported the utilization of wild or cultivated Z. mauritiana plants in a specific study area, but little is known about the secondary metabolites' profiles of the Z. mauritiana plant grown in a different environment.…”

Section: Introductionmentioning

confidence: 99%

Variability of secondary metabolites from leaves of Ziziphus mauritiana obtained from different locations in Sumbawa, Indonesia

NAIRFANA¹,

Nikmatullah

Sarjan

et al. 2022

Biodiversitas

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Abstract. Nairfana I, Nikmatullah A, Sarjan M, Tandeang A. 2022. Variability of secondary metabolites from leaves of Ziziphus mauritiana obtained from different locations in Sumbawa, Indonesia. Biodiversitas 23: 4948-4958. Bidara (Ziziphus mauritiana L.) is an evergreen shrub that grows in many parts of the world, and is an important plant in arid and semi-arid regions for the environment, food, and health. The plant has been used traditionally as medicine, and more recently, growing scientific evidence demonstrated the active compounds of bidara leaves. However, little is known about the plant's secondary metabolite profiles in different environments. This research aimed to characterize the secondary metabolites profile of bidara leaf obtained from the different habitats of semi-arid Sumbawa Island, Indonesia, and to evaluate their relationship based on cluster analysis of the secondary metabolite diversity. The leaf samples were collected from bidara plants obtained in 3 districts on Sumbawa Island: West Sumbawa (SB), Sumbawa (KS), and Dompu (DP) Districts, each from different ecosystems: lowland coastal/savanna, lowland near residential areas, and mid-highland areas of residential or forest-edge. The leaf samples were extracted by maceration with multilevel extraction using solvents with decreased polarity (h-hexane, ethyl acetate, ethanol 70%, methanol, and distilled water, respectively), followed by phytochemical screening for the presence of alkaloid, flavonoid, saponin, and phenolic. The results showed variation in the phytochemical components of bidara leaves obtained from a different environment, with secondary metabolites of DP leaves being more diverse than KS and other SB. All samples contained polar alkaloids and flavonoids, while the DP1 samples also contained non-polar flavonoids. The SB1 and DP samples also contained saponin. Interestingly, phenolic was only detected in the polar extracts of DP1 leaves. Cluster analysis based on the secondary metabolites profile distinguished the SB1 and DP1 bidara from others. Further study is required to understand if the variation is resulted from bidara adaptation to a different environment or also due to genetic variation of the bidara in Sumbawa Island.

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Antimicrobial, antioxidant and antileishmanial activities of Ziziphus lotus leaves

Cited by 12 publications

References 67 publications

Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica

Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica

Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity

Variability of secondary metabolites from leaves of Ziziphus mauritiana obtained from different locations in Sumbawa, Indonesia

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