Antimicrobial, Antineoplastic and Cytotoxic Activities of Indole Alkaloids from Tabernaemontana divaricata (L.) R.Br.

Singh, Bharat; Sharma, Ram Sharan; Vyas, Govind K.

doi:10.2174/157341211795684844

Cited by 19 publications

(21 citation statements)

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“…Indole alkaloids are classes of alkaloids containing a structural moiety of indole with various biological properties including analgesic, regulation of central and peripheral nervous systems, antimicrobial, anti-ulcer, antioxidant, and antimalarial activities (Singh et al, 2011). Isatin ( 18 ) is a natural indole alkaloid obtained from Isatis tinctoria , an anti-inflammatory and dye medicinal plant in Europe and China (Zhou and Qu, 2011).…”

Section: Plant-based Alkaloids Against Ibdmentioning

confidence: 99%

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Jiao

Zheng

et al. 2019

Front. Pharmacol.

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Inflammatory bowel disease (IBD) represents a group of intestinal disorders with self-destructive and chronic inflammation in the digestive tract, requiring long-term medications. However, as many side effects and drug resistance are frequently encountered, safer and more effective agents for IBD treatment are urgently needed. Over the past few decades, a variety of natural alkaloids made of plants or medicinal herbs have attracted considerable interest because of the excellent antioxidant and anti-inflammatory properties; additionally, these alkaloids have been reported to reduce the colonic inflammation and damage in a range of colitic models. In this review paper, we summarize the recent findings regarding the anti-colitis activity of plant-derived alkaloids and emphasize their therapeutic potential for the treatment of IBD; obvious improvement of the colonic oxidative and pro-inflammatory status, significant preservation of the epithelial barrier function and positive modulation of the gut microbiota are the underlying mechanisms for the plant-derived alkaloids to treat IBD. Further clinical trials and preclinical studies to unravel the molecular mechanism are essential to promote the clinical translation of plant-derived alkaloids for IBD.

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Section: Plant-based Alkaloids Against Ibdmentioning

confidence: 99%

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Jiao

Zheng

et al. 2019

Front. Pharmacol.

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“…2.3.1. Antifungal Activity Singh et al [54] investigated the antifungal activity of a biologically active compound from T. divaricata. A major compound from the Tabernaemontana genus, coronaridine (Table 1), was identified and isolated from the ethanolic extract of T. divaricata [54].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Antifungal Activity Singh et al [54] investigated the antifungal activity of a biologically active compound from T. divaricata. A major compound from the Tabernaemontana genus, coronaridine (Table 1), was identified and isolated from the ethanolic extract of T. divaricata [54]. In the study, coronaridine displayed weak antifungal activity against Penicillium chrysogenum, comparable with nystatin [minimum inhibitory concentration (MIC) 9.8-14.0 mg/mL] [54].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…A major compound from the Tabernaemontana genus, coronaridine ( Table 1 ), was identified and isolated from the ethanolic extract of T. divaricata [ 54 ]. In the study, coronaridine displayed weak antifungal activity against Penicillium chrysogenum , comparable with nystatin [minimum inhibitory concentration (MIC) 9.8–14.0 mg/mL] [ 54 ]. Conversely, Boligon et al [ 132 ] investigated the dichloromethane and n-butanol fractions of ethanolic leaf extracts from T. catharinensis .…”

Section: Major Bioactive Components and Biological Activities Of mentioning

confidence: 99%

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Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)

Naidoo

Dewir

et al. 2021

Plants

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Several species belonging to the genus Tabernaemontana have been well researched and utilized for their wide-ranging biological activities. A few of the most prominent species include Tabernaemontana divaricata, Tabernaemontana catharinensis, Tabernaemontana crassa, and Tabernaemontana elegans. These species and many others within the genus often display pharmacological importance, which is habitually related to their chemical constituents. The secondary metabolites within the genus have demonstrated huge medicinal potential for the treatment of infections, pain, injuries, and various diseases. Regardless of the indispensable reports and properties displayed by Tabernaemontana spp., there remains a wide variety of plants that are yet to be considered or examined. Thus, an additional inclusive study on species within this genus is essential. The current review aimed to extensively analyze, collate, and describe an updated report of the current literature related to the major alkaloidal components and biological activities of species within the genus Tabernaemontana.

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“…Regarding the chemical composition of the extracts of T. catharinensis leaves, the literature describes indole alkaloids as the main secondary metabolites [ 14 , 15 , 16 , 17 , 18 , 19 ]. Therefore, the phytochemical identification of T. catharinensis is very limited, and a more detailed characterization becomes necessary in order to identify other secondary metabolites that might be responsible for the anti-inflammatory activity of this plant.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis by HPLC–HRESI-MS and Anti-Inflammatory Activity of Tabernaemontana catharinensis

Marques

Alves

Torres-Rêgo

et al. 2018

IJMS

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Tabernaemontana catharinensis (Apocynaceae) has been popularly used by folk medicine because of its anti-inflammatory, analgesic, and antiophidic properties. This study aims to analyze the flavonoids composition of the hydroethanolic extract and of the ethyl acetate (EtOAc) and butanol (BuOH) fractions of T. catharinensis leaves, as well as to evaluate their anti-inflammatory activity using in vivo models. The phytochemical profile, determined by High-Performance Liquid Chromatography–High-Resolution Electrospray Ionization-Mass Spectrometry (HPLC–HRESI-MS), showed the presence of flavonoids mainly having an isorhamnetin nucleus. The anti-inflammatory activity was evaluated in carrageenan-induced paw edema (pre- and post-treatment) with oral administration of a T. catharinensis hydroethanolic extract (50, 100, and 150 mg/kg) and of organic fractions (50 mg/kg). The extract and fractions showed antiedematogenic activity by decreasing myeloperoxidase (MPO) production. In the zymosan-air-pouch model, the extract and fractions inhibited leukocyte migration and significantly decreased the levels of various proteins, such as MPO, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α. The cytotoxicity was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, which revealed no cytotoxicity of the extract and the fractions. These results suggest that the hydroethanolic extract and organic fractions of T. catharinensis leaves have sufficient anti-inflammatory activity to support the popular use of this plant in the treatment of inflammatory disorders.

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Antimicrobial, Antineoplastic and Cytotoxic Activities of Indole Alkaloids from Tabernaemontana divaricata (L.) R.Br.

Cited by 19 publications

References 0 publications

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)

Phytochemical Analysis by HPLC–HRESI-MS and Anti-Inflammatory Activity of Tabernaemontana catharinensis

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