Antimicrobial/Antibiotic Resistance Genes Due to Manure and Agricultural Waste Applications

Zalewska, Magdalena; Popowska, Magdalena

doi:10.1007/978-3-030-40422-2_6

Cited by 8 publications

(10 citation statements)

References 66 publications

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“…The cattle industry also makes considerable use of βlactams, first-and second-generation cephalosporins for mastitis treatment in dairy cattle. However, in the US, ceftiofur, a thirdgeneration cephalosporin, is most commonly used for treating mastitis, respiratory disease, pododermatitis and metritis, while cefquinome, a fourth-generation cephalosporin, is applied for respiratory disease (Zalewska and Popowska, 2020). Chambers et al (2015) report that cows treated with ceftiofur demonstrate an increased proportion of β-lactam resistance and MDR in bacterial isolates compared to untreated controls, as well as a greater prevalence of gene sequences associated with phages, prophages, transposable elements and plasmids.…”

Section: The Use Of Antibiotics In the Cattle Industry And Its Effectmentioning

confidence: 99%

“…Although manure is an essential and sufficient source of nitrogen for agricultural soil, it is also a rich source of antibiotics and ARB, which may be transferred to the environment and survive there even for several months (Merchant et al, 2012). Therefore, it is extremely important to develop effective treatment strategies for manure used as natural fertilizer, with the aim of eliminating, or at least reducing, the risk of releasing antibiotics, ARGs, and ARB to the environment (Zalewska and Popowska, 2020). Some antibiotics with high adsorption capacity, such as tetracyclines and quinolones, can actively adhere to soil particles, making them non-biodegradable.…”

Section: Changes In the Soil Resistome Occurring Due To Manure Applicmentioning

confidence: 99%

“…The cattle industry also makes considerable use of β-lactams, first- and second-generation cephalosporins for mastitis treatment in dairy cattle. However, in the US, ceftiofur, a third-generation cephalosporin, is most commonly used for treating mastitis, respiratory disease, pododermatitis and metritis, while cefquinome, a fourth-generation cephalosporin, is applied for respiratory disease ( Zalewska and Popowska, 2020 ).…”

Section: The Use Of Antibiotics In the Cattle Industry And Its Effect On The Cattle Manure Resistomementioning

confidence: 99%

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Antibiotics and Antibiotic Resistance Genes in Animal Manure – Consequences of Its Application in Agriculture

et al. 2021

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Antibiotic resistance genes (ARGs) are a relatively new type of pollutant. The rise in antibiotic resistance observed recently is closely correlated with the uncontrolled and widespread use of antibiotics in agriculture and the treatment of humans and animals. Resistant bacteria have been identified in soil, animal feces, animal housing (e.g., pens, barns, or pastures), the areas around farms, manure storage facilities, and the guts of farm animals. The selection pressure caused by the irrational use of antibiotics in animal production sectors not only promotes the survival of existing antibiotic-resistant bacteria but also the development of new resistant forms. One of the most critical hot-spots related to the development and dissemination of ARGs is livestock and poultry production. Manure is widely used as a fertilizer thanks to its rich nutrient and organic matter content. However, research indicates that its application may pose a severe threat to human and animal health by facilitating the dissemination of ARGs to arable soil and edible crops. This review examines the pathogens, potentially pathogenic microorganisms and ARGs which may be found in animal manure, and evaluates their effect on human health through their exposure to soil and plant resistomes. It takes a broader view than previous studies of this topic, discussing recent data on antibiotic use in farm animals and the effect of these practices on the composition of animal manure; it also examines how fertilization with animal manure may alter soil and crop microbiomes, and proposes the drivers of such changes and their consequences for human health.

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Section: The Use Of Antibiotics In the Cattle Industry And Its Effectmentioning

confidence: 99%

Section: Changes In the Soil Resistome Occurring Due To Manure Applicmentioning

confidence: 99%

Section: The Use Of Antibiotics In the Cattle Industry And Its Effect On The Cattle Manure Resistomementioning

confidence: 99%

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Antibiotics and Antibiotic Resistance Genes in Animal Manure – Consequences of Its Application in Agriculture

et al. 2021

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“…These genes harbour resistance to tetracyclines ( tet36, tetA, tetQ, tetG, tetW, tetX, tetT, tetL, tetM ), aminoglycosides ( aadA5, aadA1, strB, aadA2, aadA9 ), sulfonamides ( sul1, sul2 ), trimethoprim ( dfrA1 ), florfenicol ( floR ), antibiotics from MLSB group ( lnuB, mefA ) heavy metals ( merA ), as well as MGEs ( IntI1, intI2, tnpA, tnpA, IS1247 ), and genes encoding the MDR phenotype ( qacEdelta1 ). All of the listed genes harbour resistance to antibiotic groups commonly used in both veterinary and medical treatments (Zalewska and Popowska, 2020).…”

Section: Discussionmentioning

confidence: 99%

Pig manure treatment strategies for mitigating the spread of antibiotic resistance

Zalewska

Błażejewska

Czapko

et al. 2022

Preprint

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One of the most important public health challenges facing the world today is that posed by antibiotic resistance. Many pathogenic antibiotic-resistant bacteria and their antibiotic resistance genes, usually located on mobile genetic elements, are frequently present in the faeces of farm animals. To prevent the possibility of antimicrobial resistance transfer to the environment, these faeces should undergo treatment before being used as natural fertilizer. The two strategies for processing pig manure proposed in this study, viz. storage (most commonly used for livestock manure today) and composting, are cheap and do not require special tools or technologies. The present study examines the changes in the physicochemical properties of treated manure, in the microbiome, through metagenomic sequencing, and in the resistome, using the SmartChip Real-time PCR system compared to raw manure. This is the first such comprehensive analysis performed on the same batch of manure. Our results suggest that while none of the processes completely eliminates the environmental risk, composting results in a faster and more pronounced reduction of mobile genetic elements harbouring antibiotic resistance genes, including those responsible for multi-drug resistance. The physicochemical parameters of the treated manure are comparable after both processes; however, composting resulted in significantly higher organic matter. Overall, it appears that the composting process can be an efficient strategy for mitigating the spread of antibiotic resistance in the environment and reducing the risk of its transfer to agricultural crops and hence, the food chain. It also provides the organic matter necessary for humus formation, and increases the sorption properties of the soil and the micro and macro elements necessary for plant growth, which in turn translates into increased soil productivity.HighlightsThe changes in microbial population composition correlate with changes in specific antibiotic-resistance genes and mobile genetic elements in the studied populations.Positive correlations have been demonstrated between microbial phyla and genes coding the multi-drug resistance mechanismCo-occurrence networks showed positive correlations between antibiotic-resistance genes and mobile genetic elementsThe composting strategy was most efficient at reducing microbial loads, antibiotic resistance genes and mobile genetic elements.Composted manure can be part of a natural, safe soil fertilization strategy.

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“…This burning of agri-wastes may generate a large amounts of greenhouse gases (e.g., CO 2 , CH 4 , and N 2 O), air pollutants (e.g., CO, SO 2 ,NO x , NH 3 and volatile organic compounds) and particulate matters (Li and Chen, 2020). The increasing of agricultural organic wastes is directly responsible for some serious environmental issues including greenhouse gas emission, ground water pollution and pathogen growth (Qi et al 2020;.The application of animal wastes or its over-application to saturated soils also may cause the pollution of surrounding waters through runoff (Zalewska and Popowska, 2020).…”

Section: Agricultural Waste: a Problem Or A Treasure?mentioning

confidence: 99%

Agricultural Waste and its Nano-Management: Mini Review

et al. 2020

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A GRICULTURAL wastes are considered residues resulted during the agricultural production and after harvesting fruit and vegetable and their processing, agro-industrial by/co-products from the grapes, banana, olives and milk processing. These wastes may represent a treasure when they are turning into valuable applications (i.e., composts, biochar, adsorbents for removing pollutants from the environment and organic fertilizers) instead of burning it in open fields causing several environmental problems such as soil degradation and air pollution. The landfill disposal and open dumping of agro-wastes is a common practice in the developing countries generating huge amounts of ash, which may create serious health and environmental problems, primarily due to pollution of groundwater. Under the umbrella of the green bioeconomy and based on industrial innovation and high technology, new and better approaches for the recovery of agricultural wastes have been developed. This has contributed to guaranteeing sustainable production and its consumption, resource utilizing efficiency, the conversation of these wastes into valuable products and the reduction of negative environmental impacts.The common management of Agro-wastes may include a lot of suggested uses such as the production of biosynthesis of nanoparticles, biotechnological products, composting and biofuel production. Furthermore, a lot of bioactive compounds could be produced from the agrowastes, which have many application possibilities such as functional food, pharmaceutical and cosmetic approaches. The nano-management of agro-wastes may include using nanotechnology to convert the agro-wastes into a valuable product. This topic still has several open questions, particularly under sustainable and green bioeconomy prespective.

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Antimicrobial/Antibiotic Resistance Genes Due to Manure and Agricultural Waste Applications

Cited by 8 publications

References 66 publications

Antibiotics and Antibiotic Resistance Genes in Animal Manure – Consequences of Its Application in Agriculture

Antibiotics and Antibiotic Resistance Genes in Animal Manure – Consequences of Its Application in Agriculture

Pig manure treatment strategies for mitigating the spread of antibiotic resistance

Agricultural Waste and its Nano-Management: Mini Review

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