Antimicrobial and toxicity tests of flavonoid total Dendrophthoe pentandra (L) miq from false ashoke tree (Polyalthia longifolia)

Fahmi, Aliyah; Nasution, Rumondang Bulan; Nainggolan, Hamonangan

doi:10.24114/jpkim.v10i1.9677

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…Total flavonoids of DP leaves growing on Polyalthia longifolia (Sonn.) Thwaites (3%–9%) were deemed as potential antimicrobial agents against Streptococcus mutans , Escherichia coli , and Candida albicans with inhibitory zone diameters of 6 mm–17.25 mm, 3.55 mm–9.15 mm, and 4 mm–8.30 mm, respectively ( Fahmi et al, 2018 ). Furthermore, the aqueous extract of DF was able to inhibit the proliferation of several strains.…”

Section: Pharmacologymentioning

confidence: 99%

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Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

et al. 2023

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Dendrophthoe falcata (L.f.) Ettingsh. (DF) and Dendrophthoe pentandra (L.) Miq. (DP) have been traditionally used for the treatment of various ailments, such as cancer, ulcers, asthma, paralysis, skin diseases, tuberculosis, and menstrual troubles, in the ethnomedicinal systems of India and Indonesia. Currently, the chemical structures of 46 compounds have been elucidated from DF and DP, including flavonoids, triterpenes, tannins, steroids, open-chain aliphatics, benzyl derivates, and cyclic chain derivatives. In vitro assays have revealed their anti-tumor and anti-microbial activities. In vivo studies have unraveled their pharmacological properties against tumors, depression, fertility disorders, inflammatory responses, and so on. Additionally, their weak toxicity to rats and brine shrimp, as well as their promising applications for pharmaceutical preparations and combined medication, were also revealed. Herein, we not only recapitulated traditional medical uses, phytochemistry, pharmacology, toxicity, and applications of DF and DP but also discussed current research limitations and future perspectives, which are instructive for those interested in them and are committed to advancing parasitic plants to the Frontier of phytomedicine. We highlighted that DF and DP will become promising medical plants rather than being discarded as notorious pests, provided that more and deeper research is undertaken.

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Section: Pharmacologymentioning

confidence: 99%

“…The total flavonoids of DP leaves growing on Polyalthia longifolia (Sonn.) Thwaites were found to have an LC 50 value of 30.06 mg/L by BLST ( Fahmi et al, 2018 ).…”

Section: Toxicitymentioning

confidence: 99%

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

et al. 2023

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“…Mango leaves were extracted with methanol to generate methanol extract with a yield of 10.55 percent (b/b) and antifungal activity against Candida albicans with the highest inhibition zone at a concentration of 1000 ppm with an inhibition zone of 8.12 mm [10]. The results of the research by [6] the diameter of the inhibition zone against C. albicans was measured using the Agar Diffusion method on the leaves of the Green Champa tree parasite at total flavonoid sample concentrations of 3 %, 6 %, and 9 %, 8.30; 4 and 5.30 mm. This suggests that mango leaves and D. pentandra are related (L).…”

Section: Introductionmentioning

confidence: 99%

POTENTIAL OF ACTIVE COMPOUNDS LEAVES OF MANGO PARASITE (Dendrophthoe pentandra (L). Miq) AS ANTIFUNGAL

Mauludi

Widjajanti

Nurnawati

2022

BIOV

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Infection is a disease that is easily found in tropical areas such as Indonesia. The causes of infection that are easily found include infections due to fungi. One of the fungi that causes many infections is the Candida fungus. Tropical drugs commonly used to treat cutaneous candidiasis include nystatin, clotrimazole, miconazole, ketoconazole and other azoles. However, antifungal drugs have limitations, such as severe side effects, poor penetration into certain tissues, and the emergence of resistance. To overcome the negative effects caused by these synthetic antifungal drugs, it is necessary to explore natural antifungal drugs. One of the plants that has the potential as a medicinal plant is the mango parasite plant (Dendrophthoe pentandra (L.) Miq) which is a parasitic plant that attaches to the host which has the potential as herbal medicine. Research on the potential of active compounds in the leaves of mango parasite (Dendrophthoe pentandra (L). Miq) as antifungals has been carried out from November 2020 to June 2021 at the Genetics and Biotechnology Laboratory, Biology Department, FMIPA Sriwijaya University. The purpose of this study was to obtain fractions that had antifungal activity, to obtain isolates that had antifungal activity, what active compounds were present in the leaves of the mango parasite as antifungal, and to determine the minimum inhibitory concentration of the fungus Candida albicans. Based on research that has been carried out with methanol, n-hexane and ethyl acetate extracts that are active as antifungals, namely n-hexane and ethyl acetate extracts with an n-hexane inhibition zone diameter of 12 mm while ethyl acetate is 10 mm. Then purification of the n-hexane and ethyl acetate fractions was carried out using gravity column chromatography and the n-hexane fraction obtained two pure compounds that were active as antifungals, namely isolate N-1 with a diameter of 12 mm and N-4 with a diameter of 10 mm. Two pure acetate fractions were obtained which were active as antifungals, namely isolates E-1 with a diameter of 10 mm and E 5 with a diameter of 12 mm. Furthermore, the results of the eluate were tested by MIC and thin layer chromatography (TLC). The MIC results on isolates N-1, N-4, and E-1 were able to inhibit at a concentration of 500 ppm and were classified as strong. Meanwhile, isolate E-5 was able to inhibit at a concentration of 1000 ppm which was classified as moderate. The TLC results showed color spots on isolate N-1 which were blue, namely terpenoids, while in isolate N-4 which was orange in color were alkaloids, while in isolate E-1, the color was phenolic yellow, while in isolate E-5, which was purple, it was group terpenoids. The results of the bioautography of isolate N-1 with R¦ value: 0.9, isolate N-4 with R¦: 0.6, isolate E-1 with R¦ value: 0.8, and isolate E-5 with R¦ value: 0,9.

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Antimicrobial and toxicity tests of flavonoid total Dendrophthoe pentandra (L) miq from false ashoke tree (Polyalthia longifolia)

Cited by 2 publications

References 5 publications

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

POTENTIAL OF ACTIVE COMPOUNDS LEAVES OF MANGO PARASITE (Dendrophthoe pentandra (L). Miq) AS ANTIFUNGAL

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