Antimicrobial and Histological Effects of Nano-Neomycin Solution Against Different Microbial Population

Abstract

In the present study, pomegranate nanoparticles solution was synthesized by Sol gel method. Which show hexagonal morphology with size average (50±10) nm scanned by (SEM) and (TEM). The synergestic solution of (Neomycin and Nano-Pomegranate extract) scanned by Atomic Force Microscopy (AFM) analysis provided the information about the distribution of particles in new solution. Beside the phenolic compounds, flavonoids and tannin played crucial role in the significant antibacterial activity and the synergestic solution observed in F1 and F2 at range (9.5-12.5) mm against Staphylococcus aurous, E. coli between (5-11.5) mm, Bacillus sp. (3.9-5.5); Proteus vulgaris (4.1-5.1) mm; Salmonella typhimurium at ranges (5.8-6.5) mm, klebsiella pneumonia (3.8-4.8) mm and listeria monocytogenes (3.9-5.6) mm. the Synergistic effect of the solution increased the efficacy of their work compared to used them individually, this was shown through increasing the inhibition zone. These results were demonstrated through histopathological examination to organs examined, that identical to normal when given different concentrations of these solutions, and proof of their non-toxicity. Overall, the results elucidated a rapid, costeffective, environmentally friendly and convenient method for synthesis, which could be used as a potential antimicrobial agent against multidrug-resistant bacteria.

Синергічний вплив гентаміцину та наночасток оксиду заліза на ген phzM синьогнійної палички

“…Synergistic solutions can be prepared for future use as nanomedical therapy as well as chemotherapeutic or preventive agents against pathogens. Th ey can also be used as advantageous antibacterial product formulations in the pharmaceutical industry (Awatif & Aseel, 2023). Biosynthesized Fe 3 O 4 NPs showed maximum absorbance in the 200-300 nm region.…”