Antimicrobial and cytotoxic terpenoids from tropical green algae of the family Udoteaceae

Fenical, William; Paul, Valerie J.

doi:10.1007/bf00027651

Cited by 27 publications

(10 citation statements)

References 19 publications

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“…Members of the family Udoteaceae (Halimeda, Penicillus, and Udotea) showed a certain cytotoxic pattern in relation to the taxonomic analysis at genus level. This family is known to produce terpenes Paul 1984, Paul andFenical 1987) and, although it is not possible to exclude that one or several molecules contribute to this activity, the presence of terpenes in Chlorophyta may be related to the cytotoxic activity displayed, since this type of metabolites isolated from land sources are responsible for cytotoxic activity (Kintzios 2006). The extracts of U. flabellum and U. conglutinata showed the highest cytotoxic activity against all cancer cell lines.…”

Section: Chlorophytamentioning

confidence: 99%

In vitro cytotoxic and antiproliferative activities of marine macroalgae from Yucatán, Mexico

2009

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Extracts from 27 marine algal species (14 Rhodophyta, 5 Phaeophyta, and 8 Chlorophyta) from the Yucatán Peninsula (Mexico) were evaluated for cytotoxic and antiproliferative activity by 3(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and sulforhodamine B (SRB) assays, respectively. To determine the specificity of cytotoxic activity against tumor cells, the selective index (SI) was also calculated. The following cancer cell lines were employed: normal canine kidney (MDCK) cells, human laryngeal carcinoma (Hep-2) cells, human cervical adenocarcinoma (HeLa) cells, and human nasopharyngeal carcinoma (KB) cells. The results indicated that 44% and 51% of the algal species tested showed cytotoxic and antiproliferative activity, respectively. Most of the cytotoxic extracts were from species of Chlorophyta, with Udotea flabellum and U. conglutinate showing the highest cytotoxic activity against all the cancer cell lines. For Rhodophyta, the Bryothamnion triquetrum extract showed outstanding selective cytotoxicity against Hep-2 cells (CC 50 8.29 µg mL-1 , SI = 12.04). Two of the five species of Phaeophyta tested (Lobophora variegata and Dictyota caribaea) showed high cytotoxicity activity against the KB cell line. The data show that these species are a potential source of compounds for the treatment of certain cancer diseases.

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Section: Chlorophytamentioning

confidence: 99%

In vitro cytotoxic and antiproliferative activities of marine macroalgae from Yucatán, Mexico

2009

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“…Seaweeds are benthic marine macroalgae mainly used for the production of agar, alginate, carrageenan, liquid fertilizers and manures (Kaliaperumal et al, 1998). There are numerous reports from seaweeds derived compounds showing broad range of biological activities such as antiviral, antibiotic, anti-neoplastic, antifouling, antiinflammatory, cytotoxic and antimitotic (Naqvi et al, 1980;Caccamese et al, 1981;Fenical and Paul, 1984;Hodgson, 1984;Ballesteros et al, 1992;Bhosale et al, 2002). Harder (1917) was the first to observe antimicrobial substances in seaweeds.…”

Section: Introductionmentioning

confidence: 99%

Seasonal influence on bioactivity of seaweeds against plant pathogenic bacteria Xanthomonas axonopodis pv. citri (Hasse) Vauterin et al.

Arunkumar¹

2012

Afr. J. Microbiol. Res.

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In the present study, thin-layer chromatography (TLC) method was adopted for the fractionation of antibacterial substances from the crude extracts obtained in 1:1(v/v) chloroform : methanol of red seaweeds comprising Portieria hornemannii (Lyngbye) P. Silva, Gracilaria crassa (Harvey) J. Ag., brown Dictyota bartyrensiana Lamouroux, Hydroclathrus clathratus (C.Agardh) M.A.Howe, Sargassum wightii Greville, green Ulva (Enteromorpha) compressa (Linnaeus) Nees, and Halimeda macroloba Decaisne collected along the Coast of Pamban (Rameswaram, Gulf of Mannar, India) at four different seasons namely post-monsoon (February), summer (May), pre-monsoon (August) and monsoon (November) seasons for the year 2009. Fractionated substances detected under UV (Mechanical + disinfection) and iodine were tested for antibacterial activity against the plant pathogenic bacterium Xanthomonas axonopodis pv. citri (Hasse) Vauterin et al. which cause canker in citrus. Number of active fractions with high antibacterial activity was recorded from the crude extracts obtained in seaweeds collected during monsoon and post-monsoon whereas seaweeds collected during summer and pre-monsoon showed low antibacterial activity. UV active substances fractionated at R f 0.23 from red seaweed Porteiria hornemannii showed maximum antibacterial activity among the fractionated substances obtained on TLC from the crude extracts of all the seaweeds investigated.

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“…The brown algae were not known as producer of halogenated metabolites, but it was known as the producer of complex diterpenoids and metabolites of mixed terpenoid-aromatic compounds. These compounds possess various types of biological activities and their applications as antibiotics 22) .…”

Section: Herbal Medicine Seaweedmentioning

confidence: 99%

Ethnobotany Study of Seaweed Diversity and Its Utilization in Warambadi, Panguhalodo Areas of East Sumba District

Anggadiredja¹

2016

Jurtekling

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This paper reports the ethnobotany study of seaweed diversity in Warambadi –Panguhalodo areas of East Sumba District, the island of Sumba. The study recorded19 genera of 54 species of seaweed, which were utilized as food or edible seaweed.The group consisted of 17 species of green algae, 17 species of red algae, and 20species of brown algae. The study also reported that 18 genera of 38 species weretraditionally utilized for medicinal purposes as herbal medicine. The herbal speciesconsisted of 7 species of green algae, 13 species of red algae, and 18 species ofbrown algae.Seaweed is traditionally consumed as food in various forms: raw as salad and vegetable,as pickle with sauce of allspice or with vinegar, as relish or sweetened jellies and alsocooked for vegetable soup. As herbal medicine seaweed is usually used for traditionalcosmetics, as antipyretic and antiseptic, as vermifuges, and treatments for cough andasthma, hemorrhoid, nosebleed and boils, goiter and scrofula, stomach ailments andurinary diseases.Indigenous knowledge on seaweed still exist and are continually employed bypeople living in particular areas such as the Sumba and Sabu ethnic groups. Yet,the knowledge is gradually decreasing due to localities, socio-economic change andcultural development.

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Antimicrobial and cytotoxic terpenoids from tropical green algae of the family Udoteaceae

Cited by 27 publications

References 19 publications

In vitro cytotoxic and antiproliferative activities of marine macroalgae from Yucatán, Mexico

In vitro cytotoxic and antiproliferative activities of marine macroalgae from Yucatán, Mexico

Seasonal influence on bioactivity of seaweeds against plant pathogenic bacteria Xanthomonas axonopodis pv. citri (Hasse) Vauterin et al.

Ethnobotany Study of Seaweed Diversity and Its Utilization in Warambadi, Panguhalodo Areas of East Sumba District

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