Antimicrobial and cytotoxic capacity of pyroligneous extracts films of Eucalyptus grandis and chitosan for oral applications

Souza, Juliana Leitzke Santos de; Alves, Tomaz; Camerini, Laísa; Nedel, Fernanda; Campos, Arlene; Lund, Rafael Guerra

doi:10.1038/s41598-021-00529-7

Cited by 7 publications

(4 citation statements)

References 49 publications

(61 reference statements)

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“…Several researchers stated that some medicinal plants extract may contain secondary metabolites like essential oils, flavonoids, alkaloids, triterpenoids, and phenolic compounds which can be effective against S. mutans, a microorganism involved in the development of dental caries. [2][3][4]10,11,15 The variations in chemical structure and molecular weight for each compound might be the cause of the different antibacterial effects. The amount of hydroxyl groups and the length of the hydrocarbon chain vary among aromatic hydrocarbons.…”

Section: Discussionmentioning

confidence: 99%

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Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

Cendikiawan,

Eriwati

2023

J Indones Dent Assoc

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Introduction: In recent years, the medical field has begun to use medicinal plant in the manufacture of modern medicines. Most of the medicinal plants used have antibacterial properties such as cinnamon, clove, betel, and holy basil. These medicinal plants could be used in the manufacture of fluoride varnish to support antibacterial properties in preventing the development of dental caries. Objective: This study aimed to provide update review of medicinal plant used as antibacterial agent in the fabrication of fluoride varnish to prevent dental caries. Method: Data collection were carried out by searching the literature on article search sites, namely PubMed and Scopus which were published from 2017 to 2022. Data searches were carried out systematically using the keywords fluoride varnish, dental caries, antibacterial, and fabrication. The author performs data search, data selection, and data extraction. Results: Only nine articles were found after a thorough selection process and database search using search terms and keywords. Seven of the studies were in vitro study and two was randomized clinical trial (RCT). In the overall fluoride varnish efficacy study, adding medicinal plant as an antibacterial agent showed strong antibacterial action against S. mutans with great bacterial inhibition zone. Together with its constituent parts, the fabricating method, such as the temperature and stirring rate, influence the optimal result of fluoride varnish. Conclusion: The addition of medicinal plants and method modification in the fabrication of fluoride varnish showed potential antibacterial properties that enhance higher fluoride release.

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Section: Discussionmentioning

confidence: 99%

“…2021 15 (In vitro study) Chitosan films containing distilled pyroligneous extracts of Eucalyptus grandis (DPEC) were evaluated for antimicrobial activity against Candida albicans, Streptococcus mutans, and Lactobacillus acidophilus by direct contact test.…”

Section: Souza Et Almentioning

confidence: 99%

Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

Cendikiawan,

Eriwati

2023

J Indones Dent Assoc

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“…Nevertheless, some research has revealed the safety of using this product in specific concentrations. An in vitro cytotoxicity test for developing a chitosan biofilm and WV for dental treatments demonstrated no cell cytotoxicity at 1500 and 7500 µg mL −1 [203]. In another in vitro study, toxicity of palm kernel WV to human skin cells was found [29].…”

Section: Wood Vinegar Toxicitymentioning

confidence: 98%

The Potential of Wood Vinegar to Replace Antimicrobials Used in Animal Husbandry—A Review

Gama,

Pimenta,

Feijó

et al. 2024

Animals

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The indiscriminate use of antimicrobials in animal husbandry can result in various types of environmental contamination. Part of the dose of these products is excreted, still active, in the animals’ feces and urine. These excreta are widely used as organic fertilizers, which results in contamination with antimicrobial molecules. The impacts can occur in several compartments, such as soil, groundwater, and surface watercourses. Also, contamination by antimicrobials fed or administrated to pigs, chickens, and cattle can reach the meat, milk, and other animal products, which calls into question the sustainability of using these products as part of eco-friendly practices. Therefore, a search for alternative natural products is required to replace the conventional antimicrobials currently used in animal husbandry, aiming to mitigate environmental contamination. We thus carried out a review addressing this issue, highlighting wood vinegar (WV), also known as pyroligneous acid, as an alternative antimicrobial with good potential to replace conventional products. In this regard, many studies have demonstrated that WV is a promising product. WV is a nontoxic additive widely employed in the food industry to impart a smoked flavor to foods. Studies have shown that, depending on the WV concentration, good results can be achieved using it as an antimicrobial against pathogenic bacteria and fungi and a valuable growth promoter for poultry and pigs.

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“…Neste sentido, o extrato pirolenhoso é uma alternativa na formulação de compostos antimicrobianos, fato já discutido por Souza et al (2021) que ressalta a capacidade de inibição desse à várias espécies bacterianas, incluindo até as reconhecidas por problemas da saúde bucal.…”

Section: Ensaio De Atividade Microbiológicaunclassified

Extrato pirolenhoso como preservante de madeira e retardante de chama em situação de incêndio

Andrade¹

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O objetivo geral foi investigar a eficiência do extrato pirolenhoso e de um aditivo ignífugo (diamônio) como tratamento curativo e retardante de chama, visando suas aplicabilidades em madeiras estruturais. O estudo foi realizado em três etapas, na primeira etapa foi realizada a caracterização química do extrato pirolenhoso (EP). Foi identificado em maior área por CG- EM, o composto fenólico siringol (15,54%) e os ácidos carboxílicos, ácido butanoico (10,28%) e ácido acético (7,52%). O tratamento com 20% de EP apresentou maior redução de extrativos e lignina em relação à amostra controle, assim como maior perda de massa na análise termogravimétrica (TG). Não houve efeito significativo na resistência mecânica à compressão paralela às fibras e no módulo de ruptura (MOR) das madeiras sem e com tratamento. Na segunda etapa, foi realizado os ensaios microbiológicos simulando dois ambientes. A amostra controle e a com 10% de EP apresentaram atividades de microrganismos, enquanto para os tratamentos com 20% e 30% de EP não apresentaram. O mesmo comportamento foi observado para o ensaio com cupins. Com 20% e 30% de EP apresentaram uma mortalidade de 57,5% e 62,0%, com dano moderado e superficial, respectivamente. Por meio da técnica de densitometria de raios X para obtenção de imagens, foi possível observar a formação das galerias. No ensaio com fungos, as menores perdas de massa, foram observadas para os tratamentos com 20% (1,62%) e 30% (1,83%) do EP. Na terceira etapa, a resistência ao fogo foi realizado pelo método de propagação de chamas (Schlyter modificado) e a combustibilidade com tratamentos de 20% e 30% de EP com adição do diamônio em concentrações de 3% e 5%. Foi observado a alteração da cor com a aplicação dos tratamentos com EP, porém a mudança foi “muito apreciável” para o mercado. Para o teste de propagação de chamas, a testemunha teve perda de massa de 25,18%. Enquanto que entres os tratamentos com EP a maior perda de massa foi de 0,75% para a amostra com 20% de EP + 5% de aditivo. O aumento da temperatura média foi maior no tratamento testemunha, atingindo máximas de temperatura em 71,7 oC, 85,6 oC e 61,4 oC para altura superior, média e inferior dos termopares, respectivamente. Já os tratamentos com 20% e 30% de EP com as diferentes concentrações de aditivos, as máximas de temperatura não ultrapassaram 38 oC. Para a combustibilidade, o tratamento controle e com 20% de EP permaneceram ao final do ensaio com 20% de massa inicial, já o tratamento com 30% de EP, permaneceu com 40%. Ao aplicar o aditivo químico, os tratamentos com 20% e 30% de EP, permaneceram com cerca de 50% da massa inicial. Conclui-se que o EP foi eficaz e se mostrou um excelente aditivo contra agentes xilófagos e na formulação de retardante de chama. Mostrou-se uma alternativa ecologicamente correto e agregando valor a um coproduto carbonização da madeira, reduzindo a emissão de gases do efeito estufa. Palavras-chave: Construção civil. Madeira tratada. Propagação superficial de chamas. Situação de incêndios.

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Antimicrobial and cytotoxic capacity of pyroligneous extracts films of Eucalyptus grandis and chitosan for oral applications

Cited by 7 publications

References 49 publications

Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

Fluoride Varnish with Antibacterial Agents for Dental Caries Prevention: A Short Review on Its Fabrication

The Potential of Wood Vinegar to Replace Antimicrobials Used in Animal Husbandry—A Review

Extrato pirolenhoso como preservante de madeira e retardante de chama em situação de incêndio

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