Antimicrobial and cytotoxic activities of &lt;i&gt;Barleria prionitis&lt;/i&gt; and &lt;i&gt;Barleria grandiflora&lt;/i&gt;: A comparative study

Sawarkar, Hemant; Kashyap, Pranita; Pandey, Ajit Kumar; Singh, Mukesh; Kaur, Chanchal Deep

doi:10.3329/bjp.v11i4.27476

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…No features of cell injury, necrosis, fibrosis, inflammatory cell infiltrates, congestion, or hemorrhage were observed in the histology sections of the experimental rats of all groups. These findings exclude the potentially toxic effects of the plant in vivo, negating the conclusions made by Sawarkar et al (2016) and Honmane et al (2021).…”

Section: Effect Of Selected Plant Extracts On Histopathology Of Vital...mentioning

confidence: 75%

“…Moreover, controversial findings have been reported on the potentially toxic effects of the plant in vitro. Sawarkar et al (2016) revealed significant cytotoxic effects of ethanolic leaf extract on human gingival and human dermal fibroblast cell lines by the MTT assay. These findings were further corroborated by the findings on the brine shrimp lethality test on methanol, ethyl acetate, ethanol, and aqueous extracts of B. prionitis, which disclosed potential toxic effects of the plant (Honmane et al, 2021).…”

Section: Introductionmentioning

confidence: 98%

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Acute and sub-acute toxicological evaluation of <em>Barleria prionitis</em> Linn. in Wistar albino rats

Sachinthi S. Amarasiri,

Anoja P. Attanayake,

Mudduwa

et al. 2023

Ceylon J. Sci.

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Despite the wide usage of Barleria prionitis Linn. (Acanthaceae) in traditional medicine, controversial findings have been reported on possible toxic effects of the plant. The present study evaluated the acute and sub-acute toxic/adverse effects of B. prionitis using a healthy Wistar albino rat model. Repeated oral administration of the hexane, ethyl acetate, butanol, and aqueous extracts of the whole plant at therapeutic doses (25, 80, 70, and 120 mg/kg) revealed no mortality or treatmentrelated hematological and biochemical changes in experimental rats. However, statistically significant changes were observed in a few red cell and white cell parameters, suggesting increased erythropoiesis and immunity in experimental rats treated with B. prionitis (p<0.05). The findings on total cholesterol, glucose, and liver function tests revealed potential changes in lipid and carbohydrate metabolism and liver functions after treatments. However, the absence of statistically significant changes in the plant treated groups was noted compared to their respective vehicle control groups (p>0.05), and the lack of those changes in male and female rats excludes potential toxic effects from B. prionitis extracts. The findings on the relative weight of organs and histopathology further corroborated the safe use of the selected extracts at doses in therapeutic applications. In conclusion, the findings on acute and 28-day repeated dose oral toxicity assessments of the whole plant extracts resulted in neither mortality nor treatment-related hematological, biochemical, and histopathological changes in healthy Wistar albino rats.

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Section: Effect Of Selected Plant Extracts On Histopathology Of Vital...mentioning

confidence: 75%

Section: Introductionmentioning

confidence: 98%

Acute and sub-acute toxicological evaluation of <em>Barleria prionitis</em> Linn. in Wistar albino rats

Sachinthi S. Amarasiri,

Anoja P. Attanayake,

Mudduwa

et al. 2023

Ceylon J. Sci.

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“…17 Several plants have been reported to adversely affect reproductive function, despite their therapeutic effects, these include Barleriaprionitis, Dendrophthoefalcata, among others. [18][19][20] Testosterone is a male hormone that has significant impact on spermatogenesis. 21 Testosterone production is directly dependent on the concentration (or activity) of luteinizing hormone (LH), in the milieu secreted by the anterior pituitary gland.…”

Section: Resultsmentioning

confidence: 99%

Influence of Lophira lanceolata Leaf Extract on Reproductive Indices and Hematological Parameters in Male Wistar Rats

2021

TJNPR

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Lophira lanceolata (LL), commonly known as iron wood, belongs to the family Ohanaceo. It is distributed in West and Central Africa including the northern states of Nigeria. The local name of the plant in Hausa is Namijinkande, Ikponhon in Yoruba, Okpopia in Igbo and Maganchi in Nupe. 1 The edible oil extracted from the plant is called 'meni oil' and it has cosmetics and medicinal uses. 2 L. lanceolata is used for the treatment of toothache, liver infections, female sterility, cough, fever, heart pains, blood spitting, intercostals pain, stomach pain, dysmenorrhea, respiratory troubles, and to relieve the gripping of dysentery. 3 In Nigeria, it is used in the management of jaundice, measles and liver injury. 4,5 Traditional knowledge of indigenous communities about plant diversity makes them major contributors to primary health care for majority of the world population. While some medicinal plants are effective in the management of certain ailments, a number of them may pose a potential threat to male reproductive organ.

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“…Dose levels of 200 mg/BW and 400 mg/BW showed the maximum antihypertensive effect among all. Significant antihypertensive activity is developed by the alkaloids, flavonoids, steroids, saponins, tannin, and phenolic compounds, whose presence in B. prionitis was confirmed through phytochemical screenings [38].…”

Section: Antihypertensive Activitymentioning

confidence: 92%

A Comprehensive Review on Barleria Prionitis (L.)

Singh

Sharma

Gupta

2017

Asian J Pharm Clin Res

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Barleria prionitis is a famous perennial plant commonly known as porcupine flower or Vajradanti. It is a shrub with yellow flowers and two flat seeds shielded with matted hairs, inhabit most parts of India. Various parts of the plant such as leaves, roots, aerial parts, flowers, and stems are used in the traditional system of medicine. Conventionally, various infusions are prepared using the plant parts and utilized for the treatment of different kinds of diseases. Owing to its incredible odontalgic property, it is extensively used in treating bleeding gums and toothache. From the pharmacological point, the plant has been effectively screened for antibacterial, antifungal, antiviral, anti-inflammatory, antifertility, antioxidant, enzyme inhibitory, hepatoprotective, antihypertensive, anticancer, and anticataract activities. Compounds such as tannins, saponins, glycosides, phenolic acids, phytosterols, and terpenes have been identified in the plant. The plant contains some specific compounds such as barlenoside, barlerine, acetylbarlerine, and balarenone and some common secondary metabolites such as lupeol, β-sitosterol, vanillic acid, and syringic acid. This review provides morphological, ethnomedical, pharmacological, and phytochemical data of the plant B. prionitis.

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Antimicrobial and cytotoxic activities of <i>Barleria prionitis</i> and <i>Barleria grandiflora</i>: A comparative study

Cited by 6 publications

References 10 publications

Acute and sub-acute toxicological evaluation of <em>Barleria prionitis</em> Linn. in Wistar albino rats

Acute and sub-acute toxicological evaluation of <em>Barleria prionitis</em> Linn. in Wistar albino rats

Influence of Lophira lanceolata Leaf Extract on Reproductive Indices and Hematological Parameters in Male Wistar Rats

A Comprehensive Review on Barleria Prionitis (L.)

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