Antimicrobial and Chemotactic Activities of ω-Conotoxin Cyclic Analogues

High-throughput prediction and characterization of antimicrobial peptides from multi-omics datasets of Chinese tubular cone snail (Conus betulinus)

“…Most of the previously reported Conus AMPs presented either antibacterial (Periyasamy et al, 2012;Bernaĺdez-Sarabia et al, 2019;Younis et al, 2019) or antiparasitic activities (De Leoń-Nava et al, 2016), while only few such as an open-chain MVIIA were antifungal (Yang et al, 2001;Hemu and Tam, 2017). In our present study, eight of the nine active synthesized AMPs showed antifungal activity, suggesting a great potential to develop Conus AMPs as antifungal agents.…”

“…The complex multi-component venom contains various bioactive peptides including AMPs, which have been identified in diverse toxic animals such as spiders, snakes, scorpions and bees for promising therapeutic drug developments (de Barros et al, 2019;Tang et al, 2020;Khalil et al, 2021;Tawfik et al, 2021). AMPs in cone snails seem to be less attentional (Yang et al, 2001;Periyasamy et al, 2012;De León-Nava et al, 2016;Bernaĺdez-Sarabia et al, 2019;Younis et al, 2019;Ebou et al, 2021) compared to other animals. A previous study reported that a O1-superfamily conotoxin extracted from Californian cone (Californiconus californicus) venom can inhibit the growth of bacteria Mycobacterium tuberculosis (Bernaĺdez-Sarabia et al, 2019).…”

“…A previous study reported that a O1-superfamily conotoxin extracted from Californian cone (Californiconus californicus) venom can inhibit the growth of bacteria Mycobacterium tuberculosis (Bernaĺdez-Sarabia et al, 2019). Another type of conotoxin, namely wconotoxin MVIIA with identification from several cone snails as cyclic analogs, has shown antimicrobial activity against various bacteria (Yang et al, 2001;Hemu and Tam, 2017). With the explosion of multi-omics data, a recent review reported a proteotranscriptomic-based strategy to identify AMPs from cone snails (Ebou et al, 2021).…”

Venom peptides in association with standard drugs: a novel strategy for combating antibiotic resistance - an overview

“…In addition, conotoxins, a type of amino acids rich in glycine and cysteine, have also been reported, thereby suggesting that the flexibility of structure in relation to aromatic residues and membrane interaction by hydrophobic attraction was due to the presence of these peptides. AMPs bearing positive charge/ net hydrophobic charges have flexible chain structures and are crucial for the development of inhibitory potential against pathogens [22].…”