Antimicrobial and biodegradable materials based on ε‐caprolactone derivatives

Abstract

Appropriate wound care is pivotal in preventing wound and postsurgery infections, which remain a serious clinical problem. In this study, we report the successful fabrication of antimicrobial and biodegradable materials for possible use in the medical field. Amino functionalized polycaprolactone (PCL [Poly (CL-co-ACL)]) was synthesized via ring opening polymerization. This polymer was then functionalized via the pendant amine to induce antimicrobial efficacy. This was done through the grafting of poly(lysine) onto the amine as well as the quaternization of the amine using alkyl halides. The chemical structures of the synthesized monomers and polymers were confirmed using nuclear magnetic resonance (1 H NMR and 13 C NMR) spectroscopy and attenuated total reflection-Fourier transform infrared spectroscopy. The molecular weights of the polymers were determined using gel permeation chromatography. Nanofibre scaffolds were produced from the polymers using the electrospinning technique and these were characterized though scanning electron microscopy. The antimicrobial efficacy of the fabricated materials was tested against the Gram-positive (Staphylococcus aureus ATCC 25923) and Gram-negative (Pseudomonas aeruginosa ATCC 27853) bacteria using the disc diffusion and shake flask methods. The polymers demonstrated excellent antimicrobial efficacy. The fibers were exceptionally biodegradable which opens a lot of applications in the biomedical space.

Cranberry proanthocyanidins composite electrospun nanofibers as a potential alternative for bacterial entrapment applications

“…These results confirm that PAC:PCL ESNF retain PAC‐associated bacterial attachment properties, preventing migration and colonization of culture plate, a suitable property for surface functionalization, coating, and purification applications. Additionally, previous reports have shown the effect of PCL ESNF on preventing bacterial growth in culture plates experiments, 30 due to a mechanism of retention and preventing colonization when bacteria is entrapped into ESNF, in a static environment.…”

Enzymatic Synthesis of Polyesters and Their Bioapplications: Recent Advances and Perspectives

“…In this respect, biodegradable polyesters combined of functionalized with quaternary ammonium groups are considered as promising polymers for the development of antimicrobial materials, and several examples of their potential can be found in the literature. [ 188,248,249 ] A recent example can be found in the work of Yang et al. [ 188 ] through the synthesis of random copolyesters of poly(butylene succinate‐ co ‐butylene fumarate) (PBSF) followed by quaternization reaction giving rise to quaternary ammonium cationic copolyesters with excellent antibacterial performance against both S. aureus and E. coli .…”