Antimicrobial and antiviral activities with molecular docking study of chitosan/carrageenan@clove oil beads

Abstract

Background: Biopolymers are promising candidates that can be fabricated into hydrophilic matrices and used for many applications due to their distinctive properties such as non-toxic, biodegradable, biocompatibility, and low cost. A promising composite of chitosan and carrageenan with self-crosslinking has been prepared. Methods and Results:In this study, a rigorous approach for an inexpensive and nontoxic combination of different amounts of clove oil with two polyelectrolytes including chitosan and carrageenan in the form of beads has been prepared. The structure and the surface morphology of the beads were investigated using FTIR, X-ray diffraction (XRD), and SEM. Moreover, antimicrobial, antiviral activity, and molecular docking were evaluated. Antibacterial results revealed that chitosan/carrageenan@clove oil beads have antimicrobial activity as well as chitosan/carrageenan without clove oil against Escherichia coli AATCC25922, Pseudomonas aeruginosa AATCC27853, Staphylococcus aureus ATCC25923, Bacillus subtilis AATCC6051, and Candida albicans ATCC90028. Furthermore, maximum non-toxic concentration (MNTC) of chitosan/carrageenan@clove oil beads was (31.25 μg ml -1 ) which exhibited promising antiviral activity against Herpes simplex virus-1 (HSV-1), and was significantly higher than chitosan/carrageenan without clove oil, where antiviral activity was 82.94% and 57.64%, respectively. Eventually, docking study and computational calculation have been used to show the reactivity of the molecules. Conclusions:The developed chitosan/carrageenan@clove oil beads have shown promising properties to be used as carriers of drug delivery, tissue engineering, and regenerative medicine.

Bimetallic hydrogels based on chitosan and carrageenan as promising materials for biological applications

“…Due to increasing antimicrobial resistance for common drugs, thus 15 mm. In the same accordance with our results, Dacrory et al [42] reported that CS/CRGs beads had antibacterial and antifungal activities against human pathogenic microbes. To increase the antimicrobial activity of CS/CRG, other materials are added to enhance the activity as metal nanoparticleas and essential oils.…”

Advances in the Physico-Chemical, Antimicrobial and Angiogenic Properties of Graphene-Oxide/Cellulose Nanocomposites for Wound Healing

“…Modification via carboxymethylation, oxidation and Micheal addition reaction can introduce new functional groups in the cellulose backbone including -OH, carboxyl (-COOH), cyano (-C=N), aldehyde (-CH=O) and tetrazole groups, leading to derivatives, such as carboxymethyl cellulose (CMC), methylcellulose (MC), dialdehyde cellulose (DAC) and hydroxyethyl cellulose (HEC), as summarised in Table 2 . Over the past years, because of the increasing demand for environmentally eco-friendly and biocompatible products, the possibility to chemically modify the cellulose has boosted great advances in material science and engineering, leading to the use of cellulose derivatives in promising fields of applications, such as pharmaceutical and biomedical [ 34 ], but also electronic [ 35 , 36 ], as well as a water treatment one [ 37 , 38 ].…”

CLOVE/QURANFUL (Syzygium aromaticum L.): A REVIEW ON ITS POTENTIAL BENEFITS IN UNANI MEDICINE, BIOACTIVITIES AND CURRENT SCIENTIFIC APPLICATIONS

“…l Antiviral activity: The antibacterial, antiviral, and molecular docking activities of clove oil with two polyelectrolytes, chitosan and carrageenan, in the form of beads, was examined. The maximum nontoxic concentration (MNTC) of chitosan/ carrageenanclove oil beads was found to be 31.25 g ml, which demonstrated promising antiviral activity against Herpes simplex virus-1 (HSV-1) and was significantly higher than chitosan/carrageenan without clove oil, which had an antiviral activity of 82.94 percent and 57.64 percent [20]. In another research, eugenin was discovered to be a strong inhibitor of the Dengue virus protease (DENV).…”