Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells

Chien, Rao-Chi; Yen, Ming-Tsung; Mau, Jeng‐Leun

doi:10.1016/j.carbpol.2015.11.061

Cited by 217 publications

(101 citation statements)

References 21 publications

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“…47 The antimicrobial effect relies on the interaction between polycationic chitosan and anionic groups on the microbial cell membranes, causing the leakage of intracellular constitutes. [48][49][50] Besides, chitosan can be a chelating agent to bind metals to inhibit the microbial growth and toxin production. 51 Its antibacterial activity is relevant to the concentration and MW.…”

Section: Bacteriostatic Testmentioning

confidence: 99%

Preparation and characterization of a novel bacterial cellulose/chitosan bio-hydrogel

Jia

Wang

Huo³

et al. 2017

Nanomaterials and Nanotechnology

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Composites of chitosan chloride and bacterial cellulose were successfully prepared by in situ method. Composites of bacterial cellulose/chitosan and pristine bacterial cellulose were investigated by means of scanning electron microscope, atomic force microscope, Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and bacteriostatic test. The crystallization of bacterial cellulose was interfered and weakened by the chitosan chloride included in the growth media, resulting in lower crystallinity index and thermal stability. And interaction between two polymers is verified by the thermal gravimetric analysis. The ultrafine nanofibril network structure of bacterial cellulose was retained by the composites, while the diameters were larger and the aperture inside were smaller than those of pristine bacterial cellulose, as shown through scanning electron microscope and atomic force microscope figures. The antimicrobial effects were enhanced by the increasing concentration of chitosan in composites. All the characteristics of the composites provide evidence for the miscibility of chitosan and cellulose. Their biocompatibility is proved through our published data. It is strongly indicated that bacterial cellulose-chitosan nanocomposites have great potential in tissue engineering or pharmaceutical applications in the near future.

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Section: Bacteriostatic Testmentioning

confidence: 99%

Preparation and characterization of a novel bacterial cellulose/chitosan bio-hydrogel

Jia

Wang

Huo³

et al. 2017

Nanomaterials and Nanotechnology

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“…; Chien et al . ). The minimum MW of chitosan with DD of 84% for observation of antimicrobial activity was 2·3 kDa and the activity increased with increasing MW.…”

Section: Mode Of Action and Factors Affecting The Antimicrobial Activmentioning

confidence: 97%

“…The degree of acetylation and the MW impact antimicrobial activity of chitosan by altering the charge density of chitosan. Chitosan with higher DD has a higher positive charge density, allowing for a stronger electrostatic interaction with the negatively charged cell surface and leading to an enhanced antimicrobial activity (Chung et al 2004;Melleg ard et al 2011;Younes et al 2014;Chien et al 2016). The minimum MW of chitosan with DD of 84% for observation of antimicrobial activity was 2Á3 kDa and the activity increased with increasing MW.…”

Section: Mode Of Action and Factors Affecting The Antimicrobial Activmentioning

confidence: 99%

Challenges and opportunities related to the use of chitosan as a food preservative

Gänzle

2018

J Appl Microbiol

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Summary Chitosan has attracted a growing attention as a food preservative due to its versatility, nontoxicity, biodegradability and biocompatibility. This review aims to provide a critical appraisal of the limitations and opportunities of the use of chitosan as a food preservative. The application of chitosan as a food preservative necessitates insights into mechanisms of chitosan‐mediated cell death and injury, factors affecting chitosan activity and effects of chitosan on food safety and quality. Chitosan exerts antimicrobial activity by perturbing the negatively charged cell envelope of micro‐organisms with its polycationic structure. Intrinsic characteristics, including molecular weight and degree of deacetylation (DD), and other ambient conditions, including pH, temperature and neighbouring components, affect chitosan activity. Because the antimicrobial activity of chitosan is mainly based on ionic interactions with negatively charged components of the bacterial cell envelope, the food matrix can strongly interfere with the antimicrobial activity of chitosan. Despite its limited antimicrobial efficacy, chitosan demonstrates both bactericidal and bacteriostatic effects in specific food products. Moreover, chitosan can also enhance the efficacy of commercial intervention technologies, such as heat and pressure treatment, and aid the preservation of food quality, including retardation of lipid oxidation, weight loss and deterioration in sensory attributes.

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“…Initially, chitin and chitosan were obtained from the shell wastes of shrimps and crabs. However, their discovery in the fungal cell walls opened up the horizon for more research and biotechnological applications due to the absence of allergenic substances and less waste production (Chien et al 2016). Moreover, fungal chitin and chitosan would offer non-seasonable and stable sources of raw material and consistent characters of the product.…”

Section: Introductionmentioning

confidence: 99%

Current trends in fungal biosynthesis of chitin and chitosan

2019

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Background: Chitin and chitosan are natural biopolymers found in shell of crustaceans, exoskeletons of insects and mollusks, as well as in the cell walls of fungi. These biopolymers have versatile applications in various fields such as biomedical, food industry, and agriculture. These applications are back to their biocompatibility, biodegradability, strong antibacterial effect, and non-toxicity. Outcomes: The fungal biopolymers have many features that made them more advantageous than those biopolymers from seafood waste origin. Chitin and chitosan are not components of cell wall in all fungal species. The fungal classes of Basidiomycetes, Ascomycetes, Zygomycetes, and Deuteromycetes are known to contain chitin and chitosan in their cell walls. The amounts and characters of fungal biopolymers are affected by many factors so they should be optimized before increasing the scale of production. The statistical design of experiments is the most recent and advanced approach for optimization of various factors with more reliable results. Conclusion: Although extensively studied, further studies concerning fungal chitin and chitosan should be conducted in order to be sure of safety for human use.

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Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells

Cited by 217 publications

References 21 publications

Preparation and characterization of a novel bacterial cellulose/chitosan bio-hydrogel

Preparation and characterization of a novel bacterial cellulose/chitosan bio-hydrogel

Challenges and opportunities related to the use of chitosan as a food preservative

Current trends in fungal biosynthesis of chitin and chitosan

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