Antimicrobial and antioxidative potential of free and immobilised cellobiose dehydrogenase isolated from wood degrading fungi

Sulej, Justyna; Osińska-Jaroszuk, Monika; Jaszek, Magdalena; Grąz, Marcin; Kutkowska, Jolanta; Pawlik, Anna; Chudzik, Agata; Bancerz, Renata

doi:10.1016/j.funbio.2019.09.007

Cited by 22 publications

(12 citation statements)

References 57 publications

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“…Sulej et al (2019) showed an increase in antimicrobial production against Grampositive bacteria by P. chrysosporium, which may explain the decreased respiratory self-heating seen in the fungal-amended corn stover. 41 Similarly, dry matter loss in the corn stover was reduced in these reactors, and was only 4.4% and 2.8% in reactors 3 and 4 aer 1 week, respectively. All reactors cooled slightly during the 1 week sampling, but temperatures increased again once the reactors were sealed and aerated.…”

Section: Storage Performance and Compositional Impacts Of P Chrysospo...mentioning

confidence: 80%

Molecular and structural impacts of fungal depolymerization of corn stover to reduce pretreatment severity

Wendt

Wahlen

Groenewold

et al. 2022

Sustainable Energy Fuels

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Section: Storage Performance and Compositional Impacts Of P Chrysospo...mentioning

confidence: 80%

Molecular and structural impacts of fungal depolymerization of corn stover to reduce pretreatment severity

Wendt

Wahlen

Groenewold

et al. 2022

Sustainable Energy Fuels

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“…chrysosporium, evidenció inhibición contra el crecimiento de la cepa S. aureus cuando se usa Lactosa como sustrato, y una muy baja inhibición para E. coli y P. aeruginosa. (Sulej et al, 2019), lo que es acorde con los resultados arrojados en este estudio.…”

Section: Resultados Y Discusiónunclassified

Actividad antibacteriana y antioxidante del hongo Phanerochaete spp.

2021

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El objetivo de esta investigación fue determinar la capacidad antioxidante y antibacteriana in-vitro de extractos del hongo Phanerochaete spp. Se hicieron tres variaciones en los fermentos: 1) extracto de acetato de etilo, 2) extracto liofilizado y 3) biomasa seca. La actividad antibacteriana se evaluó por la técnica Kirby-Bauer. La actividad antioxidante se examinó por los métodos de Capacidad de Absorción de Radicales Oxigeno (ORAC, en inglés) y DPPH (2,2-difenil-1-picrilhidracilo). La muestra en acetato de etilo presentó actividad antibacteriana frente a cepas de Staphylococcus aureus, con inhibición de 54.76%. La muestra liofilizada presentó la mayor actividad antioxidante con valores de 36.59 ± 3.53 y 30.61 ± 0.20 µM Trolox/g. El extracto en acetato de etilo obtuvo más del 50% de compuestos flavonoides (531 ± 4.24 µM EC/g de extracto) en relación con la muestra liofilizada y la biomasa seca. Se concluye que el mejor procedimiento para la obtención de metabolitos secundarios de Phanerochaete spp. fue la extracción con acetato de etilo.

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“…In addition to the pentose phosphate pathway, we compared the abundance of other metabolites known for their antioxidant activity in yeast, such as adenosine, cellobiose, salicylaldehyde, and threitol [ 20 , 21 , 22 , 23 ]. All these metabolite levels were significantly higher in the mutant strain, especially in glucose medium ( Figure 6 C).…”

Section: Resultsmentioning

confidence: 99%

Metabolic Changes Induced by Deletion of Transcriptional Regulator GCR2 in Xylose-Fermenting Saccharomyces cerevisiae

Shin

Kim

2020

Microorganisms

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Glucose repression has been extensively studied in Saccharomyces cerevisiae, including the regulatory systems responsible for efficient catabolism of glucose, the preferred carbon source. However, how these regulatory systems would alter central metabolism if new foreign pathways are introduced is unknown, and the regulatory networks between glycolysis and the pentose phosphate pathway, the two major pathways in central carbon metabolism, have not been systematically investigated. Here we disrupted gcr2, a key transcriptional regulator, in S. cerevisiae strain SR7 engineered to heterologously express the xylose-assimilating pathway, activating genes involved in glycolysis, and evaluated the global metabolic changes. gcr2 deletion reduced cellular growth in glucose but significantly increased growth when xylose was the sole carbon source. Global metabolite profiling revealed differential regulation of yeast metabolism in SR7-gcr2Δ, especially carbohydrate and nucleotide metabolism, depending on the carbon source. In glucose, the SR7-gcr2Δ mutant showed overall decreased abundance of metabolites, such as pyruvate and sedoheptulose-7-phosphate, associated with central carbon metabolism including glycolysis and the pentose phosphate pathway. However, SR7-gcr2Δ showed an increase in metabolites abundance (ribulose-5-phosphate, sedoheptulose-7-phosphate, and erythrose-4-phosphate) notably from the pentose phosphate pathway, as well as alteration in global metabolism when compared to SR7. These results provide insights into how the regulatory system GCR2 coordinates the transcription of glycolytic genes and associated metabolic pathways.

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Antimicrobial and antioxidative potential of free and immobilised cellobiose dehydrogenase isolated from wood degrading fungi

Cited by 22 publications

References 57 publications

Molecular and structural impacts of fungal depolymerization of corn stover to reduce pretreatment severity

Molecular and structural impacts of fungal depolymerization of corn stover to reduce pretreatment severity

Actividad antibacteriana y antioxidante del hongo Phanerochaete spp.

Metabolic Changes Induced by Deletion of Transcriptional Regulator GCR2 in Xylose-Fermenting Saccharomyces cerevisiae

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