Antimicrobial and antioxidant properties of Artemisia L. species from western Anatolia

Erel, Ş Baykan; Reznicek, Gottfried; Şenol, Serdar; Yavaşoğlu, Nefise Ülkü Karabay; Konyalιoğlu, Sibel; Zeybek, Ahmet

doi:10.3906/biy-0912-27

Cited by 30 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that the EO yields obtained for other sagebrush species from western and southwestern Turkey, such as A. vulgaris L. (0.4%), A. santonicum L. (0.4%) and A. campestris (0.7%) [17], remained significantly lower than those of the sagebrush species in the present study.…”

Section: Extraction Yields Of Essential Oilscontrasting

confidence: 66%

Influence of Abiotic Factors on the Phytochemical Profile of Two Species of Artemisia: A. herba alba Asso and A. mesatlantica Maire

Amine

Mechchate

Ailli

et al. 2022

IJPB

View full text Add to dashboard Cite

The species of Artemisia are well known in the Mediterranean region, especially in Morocco, for their traditional uses and health benefit. In this study, we were interested in two species of Artemisia, namely A. herba alba Asso and A. mesatlantica Maire. These species were collected from different soils of the Central Middle Atlas (loamy, stony, limestone and rocky soil) with different atmospheres. Extraction of essential oils from the leaves and flowering tops was carried out by hydrodistillation in Clevenger apparatus. Chemical composition analysis was further carried out using gas chromatography coupled with mass spectrometry (GC-MS). Principal component analysis (PCA) was performed to determine the similarities and dissimilarities in the chemical compositions of these six essential oils. The results obtained showed that the essential oil contents extracted from the flowering tops vary from one species to another according to the place of harvest, altitude, soil type and climate. The essential oil yield is between 0.84% and 2.19% (mL/100 g). Chemical analysis revealed that the chemotype of A. herba alba in limestone soil with a subhumid to humid atmosphere is trans-thujone (33.78%), while camphor (46.19%) is for limestone soil with a semi-arid atmosphere, vetivenic acid (14.91%) and davana ether (14.64%) are for limestone soil with a semi-arid and arid atmosphere and camphor (18.39%) is for loamy and stony soil with a semi-arid atmosphere. As for A. mesatlantica from a rocky soil on limestone with a subhumid to humid atmosphere, the main component is camphor (44.86%), and that of limestone soil with a subhumid to the humid atmosphere trans-thujone (41.08%). In addition, HCA affirmed the PCA and allowed us to distinguish between four groups. Our findings observed differences in the chemical compositions of the isolated essential oils most likely related to many factors such as the climates in the regions of the samples collected, altitudes and soil types.

show abstract

Section: Extraction Yields Of Essential Oilscontrasting

confidence: 66%

Influence of Abiotic Factors on the Phytochemical Profile of Two Species of Artemisia: A. herba alba Asso and A. mesatlantica Maire

Amine

Mechchate

Ailli

et al. 2022

IJPB

View full text Add to dashboard Cite

show abstract

“…Consequently, n -hexane was more effective against all of the tested bacteria; this may be because the active chemicals are more soluble in hexane, this was also noticed by Abu-Darwish et al (2015) . There have been several researches on the antibacterial and antioxidant properties of Artemisia species across the world and it is thought that these plants produce important secondary metabolites that have therapeutic benefits against illness ( Erel et al , 2012 ; Javid et al , 2015 ). Hexane extract is a very effective inhibitor for clinical pathogenic bacteria, as shown by the results of the zone of inhibition and MIC investigations ( Ahameethunisa and Hopper, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-MRSA and cytotoxic activities of different solvent extracts from Artemisia herba-alba grown in Shubak, Jordan

Alghonmeen,

Dmour,

Saghir

et al. 2024

Open Vet J

View full text Add to dashboard Cite

Background: Globally, resistance to antimicrobial drugs is a major hazard to public health. Infections that were once easily treatable with antibiotics are becoming harder to control, leading to prolonged illnesses, increased mortality rates, and higher healthcare costs. Aim: This study intended to assess the antimicrobial, specifically the anti- Methicillin-resistant Staphylococcus aureus (MRSA) , and anticancer properties of different extracts obtained from A. herba-alba (AHA). Methods: The antibacterial tests of AHA were performed on two Gram-negative bacterial strains (Escherichia coli and Klebsiella pneumonia), two Gram-positive bacterial strains (Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus). Initial screening for antibacterial activities was conducted using the agar-disc diffusion technique. Subsequently, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined through the broth-dilution assay. The anticancer test was carried out in vitro on a human colorectal carcinoma cell line (HCT-116) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) )MTT( method. Results: Among all extracts, n-hexane extract of AHA was the most effective against S. aureus with the highest inhibition zone (24.67 mm) comparing to standard antibiotic (erythromycin, 24.00 mm) followed by the methanolic extract against MRSA (24.00 mm). The methanol extract of AHA showed the highest antibacterial activity against MRSA. The results of MIC and MBC of the AHA methanol extract against MRSA were 1.17±1.09 mg/mL and 9.375±0.0 mg/mL, respectively demonstrated therapeutically significant antibacterial activity. Ethyl acetate extract has no antibacterial activity against E. coli and K. pneumonia. The findings indicated that the methanol extract of AHA exhibited the highest efficacy against the colorectal carcinoma cell line (HCT-116), with an IC50 value of 126.61±13.35 µg/mL. Conclusion: These findings suggest that methanol extract of AHA could be considered as a potential agent to serve as a source of antibacterial and anticancer compounds.

show abstract

“…Previous studies on Artemisia dubia focused on its anti-microorganismal or anti-cancerous properties in vitro [ 18 , 20 ]. Phytochemical investigation of Artemisia dubia extract revealed the presence of bioactive constituents such as flavonoids, triterpenoids, phenolics, and steroids [ 19 , 20 ]. These bioactive components might underpin the anti-inflammatory action of Artemisia dubia ; indeed, flavonoids, phenolics, and steroids are anti-inflammatory [ 21 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…nonacosanoic acid, docosanoic acid, tetracosanoic acid), glycerols (e.g. 1-(O-tricosanoyl) glycerol, 1-(O-pentacosanoyl) glycerol, β-sistosterol, and flavonoids [ 19 , 20 ]. Flavonoids of medicinal plant origin exert anti-inflammatory effects both in vitro and in vivo [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Artemisia dubia folium extract-mediated immune efficacy through developing a murine model for acute and chronic stages of atopic dermatitis

Acharya,

Gautam,

Yang

et al. 2024

Lab Anim Res

View full text Add to dashboard Cite

Background Atopic dermatitis (AD) is a biphasic type of skin inflammation characterized by a predominance of type-2 (TH2) and type-1 (TH1) helper T cell-biased immune responses at the acute and persistent chronic phases, respectively. The present study was aimed to evaluate the efficacy of Artemisia dubia folium extract (ADFE) on AD-like skin lesions through developing a murine model for acute and chronic stages of AD. To induce acute phase AD, the dorsal skin of BALB/c mice was sensitized twice a week with 1% 2, 4-dinitrochlorobenzene (DNCB), followed by challenge (twice) in the following week with 0.2% DNCB. To induce persistent chronic AD, some mice were challenged twice a week for 4 more weeks. After the second challenge, the dorsal skin was exposed to 3% ADFE (five times per week) for 2 weeks (acute phase) or 4 weeks (persistent chronic phase). Results The paradigm of TH2 or TH1 predominance at the acute and chronic phase, respectively, was observed in this mouse model. During the acute phase, we observed an increased IL-4/IFN-γ ratio in splenic culture supernatants, an increased IgG1/IgG2a ratio in serum, and elevated serum IgE levels; however, the skew toward TH2 responses was diminished during the chronic stage. Compared with vehicle controls, ADFE reduced the IL-4/IFN-γ and IgG1/IgG2a ratios in acute AD, but both ratios increased during the chronic stage. Conclusions Our results suggest that ADFE concomitantly suppresses the TH2 predominant response in acute AD, as well as the TH1 predominant response in chronic AD. Thus, ADFE is a candidate therapeutic for AD.

show abstract

Antimicrobial and antioxidant properties of Artemisia L. species from western Anatolia

Cited by 30 publications

References 29 publications

Influence of Abiotic Factors on the Phytochemical Profile of Two Species of Artemisia: A. herba alba Asso and A. mesatlantica Maire

Influence of Abiotic Factors on the Phytochemical Profile of Two Species of Artemisia: A. herba alba Asso and A. mesatlantica Maire

Anti-MRSA and cytotoxic activities of different solvent extracts from Artemisia herba-alba grown in Shubak, Jordan

Evaluation of Artemisia dubia folium extract-mediated immune efficacy through developing a murine model for acute and chronic stages of atopic dermatitis

Contact Info

Product

Resources

About