Antimicrobial and Antioxidant Properties of Secondary Metabolites from White Rose Flower

Joo, Seong Soo; Kim, Yun-Bae; Lee, Do Ik

doi:10.5423/ppj.2010.26.1.057

Cited by 39 publications

(32 citation statements)

References 23 publications

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“…In our previous study, we determined that the hexane fraction of the white rose fl ower extract contained various functional volatiles (Table 2) and the abundant amount of total polyphenols (330.3 ± 20.1 mg of gallic acid equival/g of dry weight), which was approximately 2-fold higher than the amount observed in the butanol fraction and 2.6-fold higher than the amount observed in the water fraction Joo et al, 2010). These results suggested that the hexane fraction from white rose fl ower extracts may have a more potent functional activity and, thus, was selected for more indepth anti-infl ammatory analysis (Joo et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

“…These results suggested that the hexane fraction from white rose fl ower extracts may have a more potent functional activity and, thus, was selected for more indepth anti-infl ammatory analysis (Joo et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Among the several small molecules retained in plants, polyphenols (hydrolysabletannins/phenylpropanoids) are the most abundant antioxidants in our diet and have been shown to play a possible role in the prevention several chronic diseases (Bravo, 1998;Hotta et al, 2002;Gosslau et al, 2011b). Polyphenol antioxidants, such as resveratrol, inhibit the occurrence and/or growth of mammalian tumors (Jang et al, 2008), and a wide variety of phenolic substances derived from plants have been shown to display marked antioxidant and anti-infl ammatory activities, gallic acid and volatiles (1-butanol, dodecyl acrylate and cyclododecane), displayed a broad range of anti-oxidant, antimicrobial and anti-allergic effects Joo et al, 2010). In the present study, we examined the anti-infl ammatory properties of the hexane fraction from the white rose fl ower, which may be used as a natural source of bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory Effects of Hexane Fraction from White Rose Flower Extracts via Inhibition of Inflammatory Repertoires

Lee¹,

Kim²,

Kim³

et al. 2011

Biomolecules and Therapeutics

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In this study, we determined the anti-infl ammatory activity and mechanism of action of a hexane fraction (hWRF) obtained from white Rosa hybrida fl owers by employing various assays such as quantitative real-time PCR, Western blotting, and Electrophoretic-Mobility Shift Assay (EMSA). The results revealed that the hWRF had excellent anti-infl ammatory potency by reducing infl ammatory repertoires, such as inducible nitric oxide synthase (iNOS), interleukin-1β, and cyclooxygenase-2 (COX-2) in RAW264.7 cells when stimulated with lipopolysaccharide (LPS), a pro-infl ammatory mediator. The reduction of nitric oxide (NO) release from RAW 264.7 cells supported the anti-infl ammatory effect of hWRF. Interestingly, hWRF effectively inhibited LPS-mediated nuclear factor-κB (NF-κB) p65 subunit translocation into the nucleus and extracellular signal-regulated kinase (ERK)1/2 phosphorylation, suggesting that hWRF anti-infl ammatory activity may be based on inhibition of the NF-κB and MAPK pathways. Based on the fi ndings described in this study, hWRF holds promise for use as a potential anti-infl ammatory agent for either therapeutic or functional adjuvant purposes. Abstract which contribute to their chemopreventive potential (Surh et al., 2001). Moreover, natural anti-infl ammatory or immunomodulatory plant metabolites, which are abundant in fractionated extracts, have therapeutic effects against various chronic diseases, by inducing or suppressing specifi c cellular infl ammatory activities and the associated molecular signaling pathways (Aravindaram and Yang, 2010). Some polyphenols, such as catechines from green tea, appear to be the primary bioactive compounds in the suppression of key cytokines that are secreted during the infl ammation cascade (De Mjia et al., 2009;Gosslau et al., 2011a).The rose (genus Rosa), allied to its use as a source of aromatic oils for the perfume industry, has been an alternative model for pharmaceutical candidates to treat diabetes mellitus, pain, and infl ammatory diseases (Cho et al., 2003;Ng et al., 2005). Previously, we reported that the hexane fraction from white rose fl owers, which may contain high amounts of

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory Effects of Hexane Fraction from White Rose Flower Extracts via Inhibition of Inflammatory Repertoires

Lee¹,

Kim²,

Kim³

et al. 2011

Biomolecules and Therapeutics

Self Cite

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show abstract

“…Because of such problems, in vitro culture of L. iberica turns out to be a fundamental system in comparison with its cultivation in natural conditions. Secondary metabolites are generally natural components of plants with low molecular weight (Joo et al 2010). It has been shown that the phenolic compounds, especially flavonoids, have protective effects against the development of chronic diseases containing cardiovascular diseases, cancers, diabetes, aging, asthma, etc.…”

Section: Introductionmentioning

confidence: 99%

The influence of TDZ concentrations on in vitro growth and production of secondary metabolites by the shoot and callus culture of Lallemantia iberica

Pourebad

Motafakkerazad

Kosari‐Nasab

et al. 2015

Plant Cell Tiss Organ Cult

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Lallemantia iberica (Lamiaceae) has pharmaceutical and nutritional importance owing to production of oily seeds and synthesis of commercially secondary metabolites. In the present study, total phenol and flavonoids content and quantitative changes in the shoot and callus pigments of L. iberica were investigated. Moreover, some growth parameters and volatile content of in vitro grown shoots were analyzed. Nodal segments and epicotyldons were used as the explants for shoot and callus formation, respectively. In the multiplication stage of shoot culture, MS medium supplemented with six concentrations of TDZ was employed. For callus induction, 1 mg/l of TDZ, NAA and a combination of NAA and BA were used. Extracted volatile products were analyzed by GC-mass spectrometry. According to the results, the concentration range of TDZ from 0.22 to 0.66 mg/l improved the flavonoids production and the highest content was reported to be in 2 mg/l TDZ (157.5 ± 25.9 mg QE/ g); also, the highest amount of total phenol (3.86 ± 1.02 mg PYRO/g) was observed in 0.66 mg/l TDZ. For induced calli, among the three tested types of PGRs, TDZ treatment was efficient for total phenol and flavonoids. In general, the higher content of flavonoids was obtained from L. iberica shoots while the callus of this plant was efficient for total phenol production. 55 components were identified using GC-MS analysis indicating a low amount of mono and sesquiterpenes and high quantity of alkan hydrocarbons.

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“…A wide variety of chemicals have been obtained from plants, including ginsenosides, paclitaxel, echinacosides, shikonin, berberine and hypericin [20][21][22][23]. These compounds are involved in the elimination of toxic free radicals, enzyme activation, activation of immune system, controlling the expression of genes and cell death initiation [24,25]. These bioactive compounds also function as nutraceuticals, to cure cardiac diseases, flavor foods, provide antioxidants, create potential drugs, supply pharmaceuticals and act as anticarcinogens.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gibberellic Acid on Production of Biomass, Polyphenolics and Steviol Glycosides in Adventitious Root Cultures of Stevia rebaudiana (Bert.)

Ahmad

Ali

Khan

et al. 2020

Plants

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In current study, the effect of gibberellic acid was tested for production of biomass, polyphenolics and Steviol glycosides in adventitious root cultures of Stevia rebaudiana. Adventitious cultures were induced from the roots of in vitro grown plantlets on Murashige and Skoog (MS) medium containing combination of gibberellic acid (GA3; 0.5, 1.0, 1.5 and 2.0 mg/L) and naphthalene acetic acid (NAA; 0.5 mg/L). Initially, a known mass of inoculum roots were shifted into suspension media augmented with various GA3 concentrations. The growth behavior of adventitious roots was recorded every 3 days for a period of 30 days. Maximum biomass biosynthesis (13.12 g/flask) was noticed in exponential phase on 27th day in the suspension containing 2.0 mg/L of GA3. Other GA3 concentrations also displayed optimum patterns of biomass accumulation as compared to the control. Adventitious roots were investigated for total phenolic content (TPC) and production (TPP), total flavonoid content (TFC) and production (TFP), and 1, 1-diphenyl-2-picrylhydrazyl (DPPH)-based antioxidant potential. Maximum phenolics (TPC 9.84 mg gallic acid equivalent (GAE)/g-dry weight (DW)) and TPP (147.6 mg/L), TFC (5.12 mg Quercitin equivalent (QE)/g-DW) and TFP (76.91 mg/L) were observed in 2.0 mg/L GA3 treated cultures. The same concentration of gibberellic acid enhanced antioxidant activity (77.2%). Furthermore, maximum stevioside (7.13 mg/g-DW), rebaudioside-A (0.27 mg/g-DW) and dulcoside-A (0.001 mg/g-DW) were observed in roots exposed to 2.0 mg/L GA3. This is the first report on the application of GA3 on biomass accumulation and secondary metabolite production in S. rebaudiana. The current study will be helpful to scale up the adventitious root cultures in bioreactors for the production of biomass and pharmaceutically important secondary metabolites.

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Antimicrobial and Antioxidant Properties of Secondary Metabolites from White Rose Flower

Cited by 39 publications

References 23 publications

Anti-Inflammatory Effects of Hexane Fraction from White Rose Flower Extracts via Inhibition of Inflammatory Repertoires

Anti-Inflammatory Effects of Hexane Fraction from White Rose Flower Extracts via Inhibition of Inflammatory Repertoires

The influence of TDZ concentrations on in vitro growth and production of secondary metabolites by the shoot and callus culture of Lallemantia iberica

Effect of Gibberellic Acid on Production of Biomass, Polyphenolics and Steviol Glycosides in Adventitious Root Cultures of Stevia rebaudiana (Bert.)

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