Antimicrobial and Antioxidant Activities of Different Extracts from Different Parts of Zilla spinosa (L.) Prantl

Suleiman, Mohamed Hammad Adam; Ateeg, Ali A.

doi:10.1155/2020/6690433

Cited by 9 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, for the plant species growing under similar conditions, the total phenolics and flavonoid contents in L. shawii revealed 101.70 mg/gm GAE and 59.8 mg/gm of QE of the phenolics and flavonoids, respectively [ 72 ]. The current levels of Z. spinosa phenolics and flavonoids contents were nearly similar to that recorded for the species growing in the southern part of Saudi Arabia [ 73 ]. The presence of phenolics and flavonoid contents in these plants also supported the use of these plants as part of foods and livestock feed, as well as their use for different biological activities where the roles of antioxidants are involved [ 74 , 75 , 76 ].…”

Section: Resultssupporting

confidence: 60%

Comparative Phytochemical Profile and Biological Activity of Four Major Medicinal Halophytes from Qassim Flora

Mohammed

Ali

Qureshi

et al. 2021

Plants

View full text Add to dashboard Cite

Four halophytic plants, Lycium shawii, Anabasis articulata, Rumex vesicarius, and Zilla spinosa, growing in the central Qassim area, Saudi Arabia, were phytochemically and biologically investigated. Their hydroalcoholic extracts’ UPLC-ESIQ-TOF analyses demonstrated the presence of 44 compounds of phenolic acids, flavonoids, saponins, carbohydrates, and fatty acids chemical classes. Among all the plants’ extracts, L. shawii showed the highest quantities of total phenolics, and flavonoids contents (52.72 and 13.01 mg/gm of the gallic acid and quercetin equivalents, respectively), along with the antioxidant activity in the TAA (total antioxidant activity), FRAP (ferric reducing antioxidant power), and DPPH-SA (2,2-diphenyl-1-picryl-hydrazyl-scavenging activity) assays with 25.6, 56.68, and 19.76 mg/gm, respectively, as Trolox equivalents. The hydroalcoholic extract of the L. shawii also demonstrated the best chelating activity at 21.84 mg/gm EDTA equivalents. Among all the four halophytes, the hydroalcoholic extract of L. shawii exhibited the highest antiproliferative activity against MCF7 and K562 cell lines with IC50 values at 194.5 µg/mL and 464.9 µg/mL, respectively. The hydroalcoholic extract of A. articulata demonstrated better cytotoxic activity amongst all the tested plants’ extracts against the human pancreatic cancer cell lines (PANC1) with an IC50 value of 998.5 µg/mL. The L. shawii induced apoptosis in the MCF7 cell lines, and the percentage of the necrotic cells changed to 28.1% and 36.5% for the IC50 and double-IC50 values at 22.9% compared with the untreated groups. The hydroalcoholic extract of L. shawii showed substantial antibacterial activity against Bacillus cereus ATCC 10876 with a MIC value of 12.5 mg/mL. By contrast, the A. articulata and Z. spinosa exhibited antifungal activities against Aspergillus niger ATCC 6275 with MIC values at 12.5 and 50 mg/mL, respectively. These findings suggested that the L. shawii is a potential halophyte with remarkable biological properties, attributed to its contents of phenolics and flavonoid classes of compounds in its extract.

show abstract

Section: Resultssupporting

confidence: 60%

Comparative Phytochemical Profile and Biological Activity of Four Major Medicinal Halophytes from Qassim Flora

Mohammed

Ali

Qureshi

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…Standard screening procedures by Trease and Evans [68] were followed to test for the presence of alkaloids, flavonoids, cardiac glycosides, phenols, saponins, quinones, steroids, tannins, terpenes, and volatile oils in all the extracts of A. coriaria leaves. e results were expressed in terms of the relative abundance of the respective secondary metabolites [69,70]. [71] with some modifications.…”

Section: Preliminary Phytochemical Screening Of a Coriaria Leafmentioning

confidence: 99%

“…Test extracts (500 µg/mL) were prepared using sterile dimethyl sulfoxide [61]. Four sterile paper discs (6.0 mm) were saturated with each prepared test extract and dried [70]. Test bacteria (1 × 10 8 colony-forming units/mL) previously subcultured on nutrient broth and Luria-Bertani broth (for S. aureus) were aseptically inoculated onto sterile Muller Hinton broth in 90 mm Petri dishes.…”

Section: Agar Disc Diffusion Assay For Antibacterial Activitymentioning

confidence: 99%

Intraspecific Variation of Phytochemicals, Antioxidant, and Antibacterial Activities of Different Solvent Extracts of Albizia coriaria Leaves from Some Agroecological Zones of Uganda

Omara

Kiprop

Kosgei

2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Albizia coriaria Welw ex. Oliver is a customary African medicinal plant, which has a long history of utilization in the management of oxidative stress-induced and bacterial diseases. However, there is no report on the phytochemicals, antioxidant, and antibacterial activities of its leaves. The aim of this study was therefore to compare the phytochemicals, antioxidant, and antibacterial potential of A. coriaria leaves from Jinja, Kole, and Mbarara districts of Uganda. Shade-dried leaf samples were ground into powder and successively extracted with ethyl acetate, ethanol, and distilled water. Phytochemical screening indicated the presence of alkaloids, phenols, saponins, flavonoids, cardiac glycosides, tannins, and terpenes as the major secondary metabolites in the extracts. Total phenolic and flavonoid contents and total in vitro antioxidant activity were found to be the highest for ethanolic extracts, with the highest contents (101.72 ± 0.22 mg GAE/g DW; 13.23 ± 0.03 mg QE/g DW) and antioxidant potential (IC50 = 18.65 ± 0.06 mg/mL) being for leaves from Mbarara district. Antibacterial activity of the extracts determined by agar disc diffusion method revealed that ethanolic extracts had higher antibacterial activities with mean zones of inhibition of 6.00 ± 1.73 to 10.00 ± 1.73 mm, 5.00 ± 1.00 to 12.30 ± 1.53 mm, 17.00 ± 0.00 to 25.00 ± 2.65 mm, and 9.00 ± 1.73 to 16.00 ± 1.73 mm for Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi, respectively. Ethyl acetate extracts of A. coriaria leaves from Kole and Mbarara had lower antibacterial activities, while aqueous extracts and ethyl acetate extract of leaves from Jinja showed no antibacterial activity. The current study for the first time established that A. coriaria leaves possess therapeutic phytochemicals with significant in vitro antioxidant and antibacterial activities, which lend credence to their use in traditional management of oxidative stress-induced conditions and bacterial diseases in Uganda. Structural elucidation of the responsible pure compounds for the observed bioactivities as well as toxicity studies of the extracts is recommended.

show abstract

“…The identification of the following groups was considered: alkaloids, sterols, triterpenes, coumarins, flavonoids, tannins, polyphenols, carotenoids, reducing sugars, carbohydrates, and saponosides. According to the precipitate or color intensity in each sample and test, the following evaluations were given: (i) +++: represents very high, (ii) ++: indicates moderate, (iii) +: indicates little/traces, and (iv) -: indicates absent (Gul et al 2017;Suleiman and Ateeg 2020).…”

Section: The Phytochemical Screening Of the Anti-snake Venom Plant Extractsmentioning

confidence: 99%

Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon

Mengome¹,

Mewono²,

Mboma³

et al. 2021

Biodiversitas

View full text Add to dashboard Cite

Abstract. Mengome, Mewono L, Mboma R, Engohang-Ndong J, Angone SA. 2021. Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon. Biodiversitas 22: 3264-3275. Snakebites remain a major health issue in tropical and subtropical regions in the world. The limited access of antivenom sera in remote areas of many countries forces populations to rely on plant-based remedies to manage snakebite-induced injury. In this study, we conducted an ethnobotanical survey of medicinal plants used for the management of snakebites in the district of Bissok (Northern Gabon). After collecting and verifying the authenticity of the plants, we further performed their phytochemical analysis. The procedure used in this study involved a structured questionnaire and direct interviews of local populations. Overall, data collected on-site included local names, the part of the plant used, the preparation, and the route of administration. The presence of some phytochemical compounds was determined according to standard methods. Overall, a total of 29 species of plants belonging to 20 different families were reported to be used to treat snakebites. The plants used were herbs (44.80%), trees (24.10%), shrubs (20.70%), liana (10.30%), and rhizomes (6.90%). They were mainly used as poultice or crush, and to a lesser extent as decoction and maceration. Regarding the route of administration, interviewees reported mainly external use on the site of the bite. Concerning the chemical composition, we found that the antivenom plants were rich in chemical compounds known to have antivenom, antipyretic and antimicrobial properties, e.g. alkaloids, terpenoids, flavonoids, steroids, coumarins, phenols, tannins gallic Our results open avenues to develop venom enzyme inhibitory assays.

show abstract

Antimicrobial and Antioxidant Activities of Different Extracts from Different Parts of Zilla spinosa (L.) Prantl

Cited by 9 publications

References 27 publications

Comparative Phytochemical Profile and Biological Activity of Four Major Medicinal Halophytes from Qassim Flora

Comparative Phytochemical Profile and Biological Activity of Four Major Medicinal Halophytes from Qassim Flora

Intraspecific Variation of Phytochemicals, Antioxidant, and Antibacterial Activities of Different Solvent Extracts of Albizia coriaria Leaves from Some Agroecological Zones of Uganda

Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon

Contact Info

Product

Resources

About