Antimicrobial and antimycotic activity of bone matrix impregnated with a solution of sanguiritrin after sterilization with an ozone-oxygen mixture

Litvinov, Yu. Yu.; Panin, V.P.; Краснов, В. В.

doi:10.29296/25877313-2022-11-04

Cited by 1 publication

(1 citation statement)

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“…The experiments used samples obtained from fragments of the diaphysis of a femur from bovine, obtained via the author's technology using hollow cutters [28]. The obtained samples were divided into 3 batches and subjected to various sterilizing effects: a selective ozone-oxygen mixture with a concentration of (6-8) mg/l for (15)(16)(17)(18)(19)(20) minutes (the first batch), as well as irradiation with a stream of fast electrons (the second batch).…”

Section: Methodsmentioning

confidence: 99%

The Influence of Combined Sterilization Factors on the Structural and Functional Characteristics of Bone Implants

Nikolaeva,

Rozanov,

Chernyaev

et al. 2023

IJMS

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The results of a comprehensive study of the patterns of structural and functional changes in bone tissue samples after combined (ozone + radiation) sterilization are presented. The study used a different approach to the sterilization process with selective ozone or radiation exposure and an integral, combined one, based on a combined ozone–oxygen treatment of bone samples at the first stage and radiation at the second. The methods of IR spectroscopy, scanning electron microscopy with a prefix for elemental analysis, atomic force microscopy, and mechanical analysis with determination of elastic-plastic properties (Vickers microhardness index) were used in the work. It is shown that the ozone exposure used at the first stage of the combined sterilization process of bone implants does not lead to negative consequences with respect to their properties and characteristics. The results obtained serve as a scientific and methodological basis for the further improvement and optimization of sterilization technologies (including combined). They also offer a comprehensive justification of the parameters of sterilization regimes to ensure the safety of using bone implants during reconstructive operations, minimizing structural and functional changes in bone matter, and creating effective health-saving technologies and the possibility of using them for various biomedical applications.

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Section: Methodsmentioning

confidence: 99%