Antimicrobial and Anticancer Activity Studies on Green Synthesized Silver Oxide Nanoparticles from the Medicinal Plant Cyathea nilgiriensis Holttum

Pradheesh, Ganeshan; Suresh, Santhanam; Suresh, J.; Alexramani, Vincent

doi:10.5530/ijpi.2020.2.27

Cited by 19 publications

(8 citation statements)

References 16 publications

(18 reference statements)

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“…In the spectrum of the polar extract of A. lycoctonum and AgNP s synthesized with this extract, important changes were detected in the range of 1000 cm −1 and 2350 cm −1 . Our results are in agreement with several recent reports, such as [ 28 , 29 ].…”

Section: Resultssupporting

confidence: 94%

Aconitum lycoctonum L. (Ranunculaceae) mediated biogenic synthesis of silver nanoparticles as potential antioxidant, anti-inflammatory, antimicrobial and antidiabetic agents

Khan,

Assad,

Naeem-ul-Hassan

et al. 2023

BMC Chemistry

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In this study, a polar extract of Aconitum lycoctonum L. was used for the synthesis of silver nanoparticles (AgNPs), followed by their characterization using different techniques and evaluation of their potential as antioxidants, amylase inhibitors, anti-inflammatory and antibacterial agents. The formation of AgNPs was detected by a color change, from transparent to dark brown, within 15 min and a surface resonance peak at 460 nm in the UV–visible spectrum. The FTIR spectra confirmed the involvement of various biomolecules in the synthesis of AgNPs. The average diameter of these spherical AgNPs was 67 nm, as shown by the scanning electron micrograph. The inhibition zones showed that the synthesized nanoparticles inhibited the growth of Gram-positive and negative bacteria. FRAP and DPPH assays were used to demonstrate the antioxidant potential of AgNPs. The highest value of FRAP (50.47% AAE/mL) was detected at a concentration of 90 ppm and a DPPH scavenging activity of 69.63% GAE was detected at a concentration of 20 µg/mL of the synthesized AgNPs. 500 µg/mL of the synthesized AgNPs were quite efficient in causing 91.78% denaturation of ovalbumin. The AgNPs mediated by A. lycoctonum also showed an inhibitory effect on α-amylase. Therefore, AgNPs synthesized from A. lycoctonum may serve as potential candidates for antibacterial, antioxidant, anti-inflammatory, and antidiabetic agents.

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Section: Resultssupporting

confidence: 94%

Aconitum lycoctonum L. (Ranunculaceae) mediated biogenic synthesis of silver nanoparticles as potential antioxidant, anti-inflammatory, antimicrobial and antidiabetic agents

Khan,

Assad,

Naeem-ul-Hassan

et al. 2023

BMC Chemistry

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“…The most common modification of Ag 2 O NP synthesis is the so-called "green synthesis". There are reports about the use of extracts of plants Abroma augusta, Lawsonia inermis, Ficus benghal, Lippia citriodora, Eupatorium odoratum, Cleome gynandra, Aloe vera, Vaccinium arctostaphylos, Coleus aromaticus, Rhamnus virgate, Cyathea nilgiriensis, Centella Asiatica, Tridax sp., Hylocereus undatus, Paeonia emodi, Pinus longifolia and Telfairia occidentalis Telfairia occidentalis [33][34][35][36][37]51,60,[64][65][66]69,73,76,[83][84][85]; fungi Fusarium oxysporum, Kitasatospora albolonga, Rhodotorula mucilaginosa and Aspergillus terreus VIT 2013 [27,78,79,135]; and culture media of bacteria Bacillus paramycoides, Bacillus thuringiensis SSV1, Nitrobacter sp. (strain NCIM 5067) and Pseudomonas aeruginosa M6 [63,77,113,114].…”

Section: Methods For Improving Antimicrobial Propertiesmentioning

confidence: 99%

“…All mentioned microorganisms have epidemiological significance. Antibiotic-resistant strains are most often found among Escherichia coli and Staphylococcus aureus [27,[33][34][35][36]. We expected that the antimicrobial activity of Ag 2 O NPs against bacteria with different structures of cell wall (Gram-negative and Gram-positive) will greatly differ.…”

Section: Sensitive Microorganismsmentioning

confidence: 99%

“…Data on Ag 2 O NP cytotoxicity are ambiguous and constantly being enriched. There are data about the toxicity of Ag 2 O NPs/Aspergillus terreus to Dalton's lymphoma ascites (DLA) cells, which enables the use of Ag 2 O NPs in the therapy of oncological diseases [36]. High cytotoxicity of Ag 2 O/Ag NPs reported against breast cancer cell line MCF-7 and lung cancer cell line A549.…”

Section: Cytotoxicity To Human Cellsmentioning

confidence: 99%

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Ag2O Nanoparticles as a Candidate for Antimicrobial Compounds of the New Generation

et al. 2022

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Antibiotic resistance in microorganisms is an important problem of modern medicine which can be solved by searching for antimicrobial preparations of the new generation. Nanoparticles (NPs) of metals and their oxides are the most promising candidates for the role of such preparations. In the last few years, the number of studies devoted to the antimicrobial properties of silver oxide NPs have been actively growing. Although the total number of such studies is still not very high, it is quickly increasing. Advantages of silver oxide NPs are the relative easiness of production, low cost, high antibacterial and antifungal activities and low cytotoxicity to eukaryotic cells. This review intends to provide readers with the latest information about the antimicrobial properties of silver oxide NPs: sensitive organisms, mechanisms of action on microorganisms and further prospects for improving the antimicrobial properties.

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“…Studies using both chemical and green synthesis of NPs have been included. The green synthesis is a growing domain of bio-nanotechnology due to its low cost and non-toxic nature [ 69 , 79 , 80 ].…”

Section: Methodsmentioning

confidence: 99%

A Machine Learning Tool to Predict the Antibacterial Capacity of Nanoparticles

et al. 2021

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The emergence and rapid spread of multidrug-resistant bacteria strains are a public health concern. This emergence is caused by the overuse and misuse of antibiotics leading to the evolution of antibiotic-resistant strains. Nanoparticles (NPs) are objects with all three external dimensions in the nanoscale that varies from 1 to 100 nm. Research on NPs with enhanced antimicrobial activity as alternatives to antibiotics has grown due to the increased incidence of nosocomial and community acquired infections caused by pathogens. Machine learning (ML) tools have been used in the field of nanoinformatics with promising results. As a consequence of evident achievements on a wide range of predictive tasks, ML techniques are attracting significant interest across a variety of stakeholders. In this article, we present an ML tool that successfully predicts the antibacterial capacity of NPs while the model’s validation demonstrates encouraging results (R2 = 0.78). The data were compiled after a literature review of 60 articles and consist of key physico-chemical (p-chem) properties and experimental conditions (exposure variables and bacterial clustering) from in vitro studies. Following data homogenization and pre-processing, we trained various regression algorithms and we validated them using diverse performance metrics. Finally, an important attribute evaluation, which ranks the attributes that are most important in predicting the outcome, was performed. The attribute importance revealed that NP core size, the exposure dose, and the species of bacterium are key variables in predicting the antibacterial effect of NPs. This tool assists various stakeholders and scientists in predicting the antibacterial effects of NPs based on their p-chem properties and diverse exposure settings. This concept also aids the safe-by-design paradigm by incorporating functionality tools.

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Antimicrobial and Anticancer Activity Studies on Green Synthesized Silver Oxide Nanoparticles from the Medicinal Plant Cyathea nilgiriensis Holttum

Abstract: Exactly about 0.1 M of AgNO 3 was dissolved in50 mL of doubledistilled water along with10 mL of Cyathea nilgiriensis aqueous extract under under magnetic stirring at 80°C for 4 hr. The complex formed was ultracentrifuged at 10,000 rpm for 10 min, rinsed with water and further

Cited by 19 publications

References 16 publications

Aconitum lycoctonum L. (Ranunculaceae) mediated biogenic synthesis of silver nanoparticles as potential antioxidant, anti-inflammatory, antimicrobial and antidiabetic agents

Aconitum lycoctonum L. (Ranunculaceae) mediated biogenic synthesis of silver nanoparticles as potential antioxidant, anti-inflammatory, antimicrobial and antidiabetic agents

Ag2O Nanoparticles as a Candidate for Antimicrobial Compounds of the New Generation

A Machine Learning Tool to Predict the Antibacterial Capacity of Nanoparticles

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