Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes

Itoh, Tomohiro; Tsuchida, Akihiro; Muramatsu, Yuji; Ninomiya, Masayuki; Andô, Masashi; Tsukamasa, Yasuyuki; Koketsu, Mamoru

doi:10.1016/j.anaerobe.2014.03.006

Cited by 19 publications

(7 citation statements)

References 44 publications

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“…As a matter of fact, it has been reported in the literature that polysaccharides extracted from plants accelerate healing, modulate the inflammatory phase, and stimulate proliferation of dermal fibroblasts and keratinocytes [13]. Some people indicate that our data demonstrated that nostocionone isolated from NCV inhibited Propionibacterium acnes growth and P. acnes-induced inflammation, which principle is that Nost and NostD3 suppressed heatkilled P. acnes-induced nitric oxide (NO) production, suggesting that they may provide useful treatments for acne vulgaris [14]. These studies explained that NCV can repair scars and wounds.…”

Section: Introductionsupporting

confidence: 60%

Preparation, characterization and wound healing effect of alginate/chitosan microcapsules loaded with polysaccharides from Nostoc Commune Vaucher

Yang

Wang

et al. 2021

Biomed. Mater.

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Biologically active coating materials could promote the growth of granulation tissue as auxiliary materials, while natural polysaccharides could promote vascular regeneration and wound healing. Therefore, in this study, ultrasound-assisted extract of Nostoc commune Vaucher polysaccharides (UAP) yield after the process optimization was 12.89 ± 0.24%, which was used to prepare microcapsules by emulsification and cross-linking. The effect of alginate/chitosan-UAP composite materials on wound healing in an experimental rat model for 14 d and its physical properties were evaluated. In vitro experiments indicated that the UAP microcapsule material had a porous and loose three-dimensional network structure, and had good biocompatibility and swelling properties as a wound healing material. Animal experiments indicated that UAP microcapsules could extremely significantly promote wound healing (P < 0.01), and wound closure rate reached 79.16 ± 3.91% on 14th day. Meanwhile UAP microcapsules might promote angiogenesis and granulation growth by enhancing immunity and increasing the expression of VEGF and miR-21. Therefore, the composites of UAP microcapsules have shown encouraging results as a potential dressing for wound healing.

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Section: Introductionsupporting

confidence: 60%

Preparation, characterization and wound healing effect of alginate/chitosan microcapsules loaded with polysaccharides from Nostoc Commune Vaucher

Yang

Wang

et al. 2021

Biomed. Mater.

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“…The major signaling pathway used by most TLRs involves the activation of the NF-κB, which in turn leads to the expression of various cytokines, chemokines, adhesion molecules and granulopoiesis factors, all of which would contribute to the cutaneous host defense against P . acnes [ 40 ]. Our results indicate that P5 effectively inhibits P .…”

Section: Discussionmentioning

confidence: 99%

Suppression of Propionibacterium acnes Infection and the Associated Inflammatory Response by the Antimicrobial Peptide P5 in Mice

et al. 2015

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The cutaneous inflammation associated with acne vulgaris is caused by the anaerobic bacterium Propionibacterium acnes through activation of the innate immune system in the skin. Current standard treatments for acne have limitations that include adverse effects and poor efficacy in many patients, making development of a more effective therapy highly desirable. In the present study, we demonstrate the protective effects of a novel customized α-helical cationic peptide, P5, against P. acnes-induced inflammatory responses in vitro and in vivo. Application of P5 significantly reduced expression of two inflammatory cytokines IL-8 and TNF-α in P. acnes-treated primary human keratinocytes, where P5 appeared to act in part by binding to bacterial lipoteichoic acid, thereby suppressing TLR2-to-NF-κB signaling. In addition, in a mouse model of acne vulgaris, P5 exerted both anti-inflammatory and antimicrobial effects against P. acnes, but exerted no cytotoxic effects against skin cells. These results demonstrate that P5, and perhaps other cationic antimicrobial peptides, offer the unique ability to reduce numbers P. acnes cells in the skin and to inhibit the inflammation they trigger. This suggests these peptides could potentially be used to effectively treat acne without adversely affecting the skin.

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“…( H ) Structure of indole alkaloids [ 7 , 8 , 27 , 41 ]. ( I ) Structure of β-ionone derivatives [ 4 , 27 , 41 ]. ( J ) Structure of an anthraquinone derivative [ 25 ].…”

Section: Chemical Composition and Nutritional Characteristicsmentioning

confidence: 99%

“…They also found that nostocionone (Nost) and one of its derivatives (NostD3) significantly inhibit Propionibacterium acnes growth. Furthermore, they investigated the effects and detected that both Nost and NostD3 suppressed heat-killed P. acnes -induced nitric oxide (NO) production by suppressing of inducible NO synthase expression, following inactivation of NF-κ.B, and that NostD3 showed higher efficacy than Nost [ 27 ]. Hardardottir et al .…”

Section: Anti-inflammatory and Antibacterial Properties Of mentioning

confidence: 99%

Healthy efficacy ofNostoc communeVaucher

Guo

2017

Oncotarget

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Nostoc commune Vaucher, a macroscopic cyanobacterium, has long been appreciated as a healthy food and traditional medicine worldwide. Accumulated evidence has demonstrated that it possesses a wide range of remarkably protective physiological and pharmacological activities, largely based on animal and in vitro studies. In this review, we summarise and update evidence regarding the chemical composition and nutritional characteristics of Nostoc commune Vaucher, and comprehensively discuss the recent studies on the antioxidative, anti-inflammatory, anti-carcinogenic and immune regulation properties of Nostoc commune Vaucher and Nostoc commune Vaucher-derived extracts. The available results demonstrate the potential of it to act as a functional food for the amelioration of human associated diseases. More details from human clinical trials should be a matter of further investigation.

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Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes

Cited by 19 publications

References 44 publications

Preparation, characterization and wound healing effect of alginate/chitosan microcapsules loaded with polysaccharides from Nostoc Commune Vaucher

Preparation, characterization and wound healing effect of alginate/chitosan microcapsules loaded with polysaccharides from Nostoc Commune Vaucher

Suppression of Propionibacterium acnes Infection and the Associated Inflammatory Response by the Antimicrobial Peptide P5 in Mice

Healthy efficacy ofNostoc communeVaucher

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