Abstract:Antimicrobial peptides have received increased attention due to the increasing prevalence of antibiotic‐resistant bacteria. However, the development of antimicrobial peptides for clinical applications remains a huge challenge. SPA ([D‐rg1, D‐Trp5,7,9, Leu11]SP), an analog of substance P, is a broad‐spectrum neuropeptide antagonist. In this study, we found that SPA could efficiently kill Gram‐positive and Gram‐negative bacteria by membrane disruption, similar to antimicrobial peptides. In addition, SPA showed h… Show more
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