Antimicrobial Agents from Marine Algae

Sims, James J.; Donnell, Mark S.; Leary, J. V.; Lacy, George H.

doi:10.1128/aac.7.3.320

Cited by 53 publications

(20 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Details of the structure assignments, based on derivatization, mass spectral fragmentation patterns, and isolation of individual compounds from sample AHBE 943 have been described elsewhere (Caccamese and Rinehart 1978). In view of laurinterol's known antibacterial activity (Sims et al 1975)* and its abundance (peak F) in the traces of Figure 1, the antimicrobial activity of the L. decidua extracts is not surprising.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Laurencia Species by Gas Chromatography-Mass Spectrometry

Caccamese¹,

Hager²,

Rinehart³

et al. 1979

Botanica Marina

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Characterization of Laurencia Species by Gas Chromatography-Mass Spectrometry

Caccamese¹,

Hager²,

Rinehart³

et al. 1979

Botanica Marina

View full text Add to dashboard Cite

show abstract

“…Evaluation of the related sesquiterpenes allolaurinterol (151) [166,248,259,260,855,877], allolaurinterol acetate (152) [152,260], debromoallolaurinterol (149) [248], debromoallolaurinterol acetate (150) [152], isolaurinterol (161) [62,201,267,279,877], laurinterol (231) [62,105,137,309,877], debromolaurinterol (226) [309,855,878], and isodebromolaurinterol (229) [201,267,279] has been performed in several, albeit fragmented, studies, which do not allow direct comparison of the structural features with the reported antimicrobial activities.…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

“…The antibacterial and/or antifungal activities of the acetogenins laurenmariallene (741) [74], chinzallene (749) [105], (12E)-lembyne A (759) [62], lembyne A (763) [165], (3Z)-laurenyne (798) [513], (Z)-chondriol (803) [878], ent-854 [152], desepilaurallene (862) [152], and (3Z )-chlorofucin (875) [238] have also been evaluated in a number of studies.…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

The Laurencia Paradox: An Endless Source of Chemodiversity

Harizani

Iοannou

Roussis

2016

Progress in the Chemistry of Organic Natural Products

View full text Add to dashboard Cite

Nature, the most prolific source of biological and chemical diversity, has provided mankind with treatments for health problems since ancient times and continues to be the most promising reservoir of bioactive chemicals for the development of modern drugs. In addition to the terrestrial organisms that still remain a promising source of new bioactive metabolites, the marine environment, covering approximately 70% of the Earth's surface and containing a largely unexplored biodiversity, offers an enormous resource for the discovery of novel compounds. According to the MarinLit database, more than 27,000 metabolites from marine macro- and microorganisms have been isolated to date providing material and key structures for the development of new products in the pharmaceutical, food, cosmeceutical, chemical, and agrochemical sectors. Algae, which thrive in the euphotic zone, were among the first marine organisms that were investigated as sources of food, nutritional supplements, soil fertilizers, and bioactive metabolites.Red algae of the genus Laurencia are accepted unanimously as one of the richest sources of new secondary metabolites. Their cosmopolitan distribution, along with the chemical variation influenced to a significant degree by environmental and genetic factors, have resulted in an endless parade of metabolites, often featuring multiple halogenation sites.The present contribution, covering the literature until August 2015, offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. Since mollusks feeding on Laurencia are, in many cases, bioaccumulating, and utilize algal metabolites as chemical weaponry against natural enemies, metabolites of postulated dietary origin of sea hares that feed on Laurencia species are also included in the present review. Altogether, 1047 secondary metabolites, often featuring new carbocyclic skeletons, have been included.The chapter addresses: (1) the "Laurencia complex", the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; (2) the secondary metabolites, which are organized according to their chemical structures and are classified into sesquiterpenes, diterpenes, triterpenes, acetogenins, indoles, aromatic compounds, steroids, and miscellaneous compounds, as well as their sources of isolation which are depicted in tabulated form, and (3) the biological activity organized according to the biological target and the ecological functions of Laurencia metabolites.

show abstract

“…Phenols have been identified in several algal species as biologically active compounds (Vairappan, et al, 2001). Many compounds of marine algae show anti-bacterial activities as polysaccharide (Laurienzo, 2010), lyengaroside (Ali et al, 2002), polyhydroxy lated fucophlorethol (Sandsdalen et al, 2003), bromophenols (Oh et al, 2008), guaiane sesquiterpene (Chakraborty & Lipton, 2010), lactone malyngolide (Cardelina et al, 1979) cycloeudesmol (Sims et al, 1975), polyphenolic compound (Devi, 2008), halogenated compound (Vairappan, 2003) and quinone metabolite (Horie et al, 2008). Flavonoids comprise a large group of naturally compounds widely distributed in the algae and some of these compounds have been reported to contain various and potent biological activities including anti oxidative tissue protective and tumoristatic effects as well as the inhibition of hepatic cholesterol biosynthesis (Krant et al, 2005;Kim et al, 2007;Matanjun et al, 2008 andVolk, 2009).…”

Section: Resultsmentioning

confidence: 99%

Controlling of Microbial Growth by Using Cystoseira barbata Extract

et al. 2017

View full text Add to dashboard Cite

MARINE algae contain a variety of bioactive secondary metabolites and several compounds have been derived from them for prospective development of novel drugs by the pharmaceutical industries. In this laboratory experiment Cystoseira barbata was isolated from Red Sea coastal water (Safaga, Egypt). It was evaluated due to its bioactivities potential. Where the algal extract proved a potent activity against bacterial and fungal strains ranged between medium and high suppression action. It showed that Gram positive bacteria Bacillus subtilis and Staphylococcus aureus were more sensitive than Gram negative bacteria where Serratia marcescens, Pseudomonas aeuroginosa and fungus Candida albicans. Phyto-chemical analyses showed that C. barbata recorded the highest percentages of the flavonoids, phenols and saccharides compounds. Among the bioflavonoids determined Acacetin, Kaemp.3-(2-pcomaroyl) glucose, Rosmarinic and phenols were E-Vanillic, Benzoic and Ferulic were present in high percentages in the alga analyzed. The results indicated scope for utilizing this alga as a source of antibacterial and antifungal substances.

show abstract

Antimicrobial Agents from Marine Algae

Cited by 53 publications

References 7 publications

Characterization of Laurencia Species by Gas Chromatography-Mass Spectrometry

Characterization of Laurencia Species by Gas Chromatography-Mass Spectrometry

The Laurencia Paradox: An Endless Source of Chemodiversity

Controlling of Microbial Growth by Using Cystoseira barbata Extract

Contact Info

Product

Resources

About