Antimicrobial activity screening of some sulfonamide derivatives on some Nocardia species and isolates

Abstract

Nocardia are aerobic, catalase-positive, Gram-positive microorganisms and typically acid-alcohol fast at some stage of the growth cycle. The genus Nocardia, a member of Mycolata group, is clinically important because it is an opportunistic pathogen. The sulfonamide derivative medicines are prefered to cure infection caused by Nocardia, such as nocardiaosis and mycetoma. Antimicrobial activities of seven sulfonamide derivatives have been investigated against some Nocardia species and isolates using the disk diffusion method on Sensitest agar medium (Oxoid). Thirty-six organisms, which consisted of 10 soil isolates selected from different clusters of Aymen study (2003), six clinical isolates provided by Ege University, Medical School, Microbiology and Clinical Microbiology Department, four reference strains, 15 type strains and a control strain of Staphylococcus aureus ATCC 43300 were tested. The strongest inhibition was observed in the cases of IV [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], V [N-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] and III [N-(2-Hydroxy-phenyl)-4-methyl-benzenesulfonamide] against Nocardia. Introducing a hydroxyl group into the ortho position on the ring increased the antimicrobial activity. Substitution of the electron withdrawing groups such as a nitro group increased the antimicrobial activity remarkably.

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

“…Some benzimidazoles [ 9 , 11 ] and sulphonamides [ 12 , 13 ] have recently presented promising antimicrobial activities. Benzimidazolylbenzenesulfonamides show a variety of pharmacological activities due to their affinity toward various cellular protein targets or enzyme inhibitors, such as the peptide-like thrombin inhibitor [ 14 ], NR2B-selective N -methyl- D -aspartate antagonists [ 15 ], inhibitors of the enzyme 11 β -hydroxysteroid dehydrogenate [ 16 ], and the human immunodeficiency virus type I integrase inhibitor [ 17 ].…”

Benzimidazol halkasının antimikrobiyal aktivitesine etki eden yapısal faktörlerin disk difüzyon ve mikrodilüsyon metodu ile ayrıntılı incelenmesi

“…Test edilen suşlara karşı benzimidazol türevlerinin (1-15) minimum inhibisyon konsantrasyonları (MIC'ler), 96 çok oyuklu mikro plakalarda broth mikrodilüsyon metodu kullanılarak belirlenmiştir [12][13] Ekim yapılan ve disklerin yerleştirildiği petriler37°C'de, inkübe edilmiştir. Diskin etrafındaki inhibisyon zonu, genellikle büyümenin bir kenardan diğer kenara inhibe olduğu ve bölgenin en keskin kenarına tekabül eden ve kumpast ile milimetre (mm) cinsinden ölçülebilen çapı [15] olarak alınmıştır. Benzimidazol türevi bileşiklerin her bir test suşuna karşı oluşturduğu antimikrobiyal etki, standart olarak kullanılan antimikrobik ajanın oluşturduğu inhibisyon zonları ile kıyaslanarak değerlendirilmiştir.…”

Synthesis, Antibacterial and Lipoxygenase Inhibition Studies of <i>N</i>-(Alkyl/aralkyl)-<i>N</i>-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides

“…5,6 Sulfonamides possess antimicrobial activity against Gram-positive and Gramnegative bacteria and act as carbonic anhydrase inhibitors. 7,8,9,10 In combination with Trimethoprim, sulfonamides are used for the treatment of urinary tract infections and prevent parasitic and malarial infections. 11 In addition to antiviral agents sulfonamides are also used as antitumor agents, diuretics, antileprotic, tuberculostatics and oral hypoglycemic drugs.…”