Antimicrobial Activity of Two Novel Venoms from Saudi Arabian Scorpions (Leiurus quinquestriatus and Androctonus crassicauda)

Alajmi, Reem A.; Alghamdi, Sumaiah; Barakat, Ibrahim A. H.; Mahmoud, Abeer M.; Abdon, Nuzha; Al-Ahidib, Mohamed; Abdel‐Gaber, Rewaida

doi:10.1007/s10989-019-09816-4

Cited by 6 publications

(3 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Alajmi et al (2020), scorpion's venom is a valuable source of active chemicals, including several polypeptides, making it crucial in a variety of biological applications. Indeed, polypeptides (which block sodium, potassium, or calcium-gated channels) as well as enzymes are the two most significant substances in scorpion's venom (Al-Malki and Abdelsater, 2020).…”

Section: Tablementioning

confidence: 99%

2-In vitro Scolecidal Effects of Chitosan (isolatedfrom some scorpions), Chitosan Nanoparticles, Scorpion’S Venom, and Scorpion Venom-Loaded Chitosan Nanoparticles

El-Sheikh

Badry²,

Gobaara³

et al. 2023

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

Hydatid cysts of Echinococcus granulosus were recovered from 27.59% (149/540) of camels Camelus dromedarius from a slaughterhouse in Cairo. The organ distribution of cysts was 57=38.26% in the lung, 65=43.62 % in the liver, 23=15.44 % in both liver and lungs, and 4=2.68% in the other organs such as the brain, tongue, and spleen, etc. The investigation looked at how four compounds from scorpions: chitosan, chitosan nanoparticles (Cs-NPs), venom as well as venom-loaded chitosan nanoparticles (V-CN) affect against in vitro hydatid cyst protoscoleces. Aseptically, cyst fluid protoscoleces were aspirated. Each of the aforementioned compounds was always examined in triplicates at doses of 20, 50, and 100 µg/ml for incubation periods of 30, 60, 120, and 240 min to show its scolicidal effects. Using the 0.1% eosin test, the viability of protoscoleces was determined.According to the degree of deacetylation (DDA), concentration, exposure period, and size, all compounds demonstrated statistically significant differences (P > 0.05) against the protoscoleces activity. Chitosan and chitosan nanoparticles had a scolicidal action, directly related to DDA and inversely proportional to size. The most effective scolicidal compound was venom-loaded chitosan nanoparticles, which destroyed all protoscoleces at a concentration of 100 µg/ml, after 240 min of incubation.

show abstract

Section: Tablementioning

confidence: 99%

2-In vitro Scolecidal Effects of Chitosan (isolatedfrom some scorpions), Chitosan Nanoparticles, Scorpion’S Venom, and Scorpion Venom-Loaded Chitosan Nanoparticles

El-Sheikh

Badry²,

Gobaara³

et al. 2023

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

show abstract

“…Venom was collected in fine glass sterile micropipette by electrical stimulation (15 volts) of telson (last segment in the abdomen) Venom of 250 scorpions was dissolved in deionized water and centrifuged at 15000 rpm for 10 minutes. Supernatant was stored at -80 C until further use [23][24][25] .…”

Section: Scorpion Venom Collectionmentioning

confidence: 99%

“…50µl of sterile deionized water was added in each eppendorf containing venom and centrifuged at 15000 rpm for 10mins. The supernatant was pooled separately and stored at -80ºC till further processing 23,25 .…”

Section: Preparation Of Scorpion Venommentioning

confidence: 99%

Evaluation of antimicrobial potential of partially purified proteins/peptide of Yellow Scorpion Buthus sindicus against Carbapenem-Resistant Acinetobactor baumannii and Pseudomonas aeruginosa.

Urooj

Amin

Haque

2021

Int. j. endorsing health sci. res.

View full text Add to dashboard Cite

Background: Increasing antimicrobial resistance of microbes is one of the leading challenges faced by the medical community and human health. This study focused on a local scorpion species (Buthus sindicus) of Pakistan known for its potent antibiotic properties against Carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Methodology: Venom extracted from Buthus sindicus tested against Carbapenem-resistant A. baumannii and P. aeruginosa in both crude and partially purified forms. The antibacterial Screening was performed by the Agar-disc diffusion method, using different concentrations of venom while using commercially available antibiotics as positive controls. Results: Among both two species P. aeruginosa and A. baumannii, were tested, there is no zone of inhibition found in any form of Buthus sindicus in the Disc Diffusion Method. Scorpion venom was processed with deionized water, PBS, and Tris-HCl and observed no difference in antibacterial activity. Conclusion: Our study concluded that no antimicrobial activity was found against any selected drug-resistant pathogens in the venom of Buthus sindicus, probably because of the lack of disulphide bonds.

show abstract

Chitosan-Coated Scorpion Venom Ameliorates Acute Lung Injury Caused by Klebsiella Pneumoniae

Oskay,

Sahin,

Caliskan

et al. 2024

Int J Pept Res Ther

View full text Add to dashboard Cite

Antimicrobial Activity of Two Novel Venoms from Saudi Arabian Scorpions (Leiurus quinquestriatus and Androctonus crassicauda)

Cited by 6 publications

References 52 publications

2-In vitro Scolecidal Effects of Chitosan (isolatedfrom some scorpions), Chitosan Nanoparticles, Scorpion’S Venom, and Scorpion Venom-Loaded Chitosan Nanoparticles

2-In vitro Scolecidal Effects of Chitosan (isolatedfrom some scorpions), Chitosan Nanoparticles, Scorpion’S Venom, and Scorpion Venom-Loaded Chitosan Nanoparticles

Evaluation of antimicrobial potential of partially purified proteins/peptide of Yellow Scorpion Buthus sindicus against Carbapenem-Resistant Acinetobactor baumannii and Pseudomonas aeruginosa.

Chitosan-Coated Scorpion Venom Ameliorates Acute Lung Injury Caused by Klebsiella Pneumoniae

Contact Info

Product

Resources

About