Antimicrobial activity of tiger's betel (<i>Piper porphyrophyllum</i> N.E. Br., Piperaceae)

Wiart, Christophe; Hannah, N. A.; Yassim, M.; Hamimah, H; Sulaiman, M.

doi:10.1002/ptr.1564

Cited by 4 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The leaves of the Piper betel plant have long been in use in the local Indian system of medicine for its antioxidant and antimicrobial properties [42,43]. Some groups of researchers have reported the antimicrobial properties of Piper betel extracts [43,44]; however to the best of our knowledge, this is the first report of the antibacterial activity of Piper betel derivatives against Vibrio spp.…”

Section: Resultsmentioning

confidence: 99%

Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen

et al. 2019

View full text Add to dashboard Cite

The natural population of the aquatic environment supports a diverse aquatic biota and a robust seafood industry. However, this environment also provides an appropriate niche for the growth of pathogenic bacteria that cause problems for human health. For example, species of the genus Vibrio inhabit marine and estuarine environments. This genus includes species that are pathogenic to aquaculture, invertebrates, and humans. In humans, they can cause prominent diseases like gastroenteritis, wound infections, and septicemia. The increased number of multidrug resistant (MDR) Vibrio strains has drawn the attention of the scientific community to develop new broad-spectrum antibiotics. Hence, in this paper we report the bactericidal effects of compounds derived from Piper betel plants: piperidine, chlorogenic acid, and eugenyl acetate, against various strains of Vibrio species. The different MIC90 values were approximately in a range of 2–6 mg/mL, 5–16 mg/mL, 5–20 mg/mL, and 30–80 mg/mL, for piperidine, chlorogenic acid, and eugenyl acetate, respectively. Piperidine showed the best anti-Vibrio effect against the five Vibrio species tested. Interestingly, combinations of sub-inhibitory concentrations of piperidine, chlorogenic acid, and eugenyl acetate showed inhibitory effects in the Vibrio strains. Furthermore, these compounds showed synergism or partial synergism effects against MDR strains of the Vibrio species when they were incubated with antibiotics (ampicillin and chloramphenicol).

show abstract

Section: Resultsmentioning

confidence: 99%

Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen

et al. 2019

View full text Add to dashboard Cite

show abstract

“…G. scortechinii was investigated as part of our study on the medicinal plants of Asia-Pacific ( 9 , 10 , 97–100 ) A critical factor for Goniothalamus’ use as a medicinal herb is its content of styryl-lactones, which promote apoptosis in mammalian cells. One might propose the hypothesis that the abortifacient and/or post-natal and anti-inflammatory reported traditional uses of Goniothalamus species might involve styryl-lactones since apoptosis is known to play a crucial role in trophoblasts of patients with recurrent spontaneous abortion of unidentified cause, and in T cells in the human decidua as defense mechanism against rejection of fetal allograft by the maternal immune system ( 101 , 102 ).…”

Section: Discussionmentioning

confidence: 99%

Goniothalamus Species: A Source of Drugs for the Treatment of Cancers and Bacterial Infections?

Wiart

2007

Evidence-Based Complementary and Alternative Medicine

112

View full text Add to dashboard Cite

Irrespective of the presence of cytotoxic acetogenins and styryl-lactones in the genus Goniothalamus, only 22 species in the genus Goniothalamus, out of 160 species (13.7%) have so far been investigated. In an effort to promote further research on the genus Goniothalamus which could represent a source of drugs for the treatment of cancers and bacterial infections, this work offers a broad analysis of current knowledge on Goniothalamus species. Therefore, it includes (i) taxonomy (ii) botanical description (iii) traditional medicinal uses and (iv) phytochemical and pharmacological studies. We discuss the molecular mechanisms of actions of acetogenins and styryl-lactones, with some emphasis on the possible involvement of protein kinase, Bax and TRAIL receptors in the cytotoxic effects of styryl-lactones. We also report (v) the growth inhibition of several nosocomial bacteria by Goniothalamus. scortechinii. The crude methanol extract of G. scortechinii showed a good and broad spectrum of antibacterial activity against both Gram-negative and Gram-positive bacteria.

show abstract

“…AChE inhibition (I%) 5,7-Dimethoxyflavone (3) 47.5% 4,5,7-Trimethoxyflavone (4) 52.8% 3',4',5,7-Tetramethoxyflavone (5) 58.2% 5-Hydroxy-7-methoxyflavone (6) 25.5% 5-Hydroxy-4ʹ,7-dimethoxyflavone (9) 24.2% Galantamine b…”

Section: Samplesmentioning

confidence: 99%

“…The leaves are simple, spiral and exstipulate. In the Philippines, the leaf is used to treat splenomegaly [5]. We have recently reported the chemical compositions and biological activities of the essential oils from this species [6].…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents and acetylcholinesterase inhibitory activity of Piper abbreviatum Opiz

Salleh¹,

Nafiah²,

Khong³

et al. 2021

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

Plants of the genus Piper have long been used as medicinal herbs. The chemistry of Piper species has been widely investigated and phytochemical investigations conducted in all parts of the world have led to the isolation of a number of physiologically active compounds. Thus, this study was carried out to investigate the phytochemicals from Piper abbreviatum and their acetylcholinesterase inhibitory activity, which has not been previously investigated. Fractionation and purification of the aerial parts of P. abbreviatum led to the isolation and identification of five methoxylated flavonoids, namely 5,7-dimethoxyflavone, 4ʹ,5,7-trimethoxyflavone, 3',4',5,7-tetramethoxyflavone, 5-hydroxy-7-methoxyflavone, 5-hydroxy-4ʹ,7-dimethoxyflavone, together with lupeol, lupenone, β-sitosterol, and β-sitostenone. The structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that all isolated flavones were found to inhibit AChE with percentage inhibition values ranged from 24.2 to 58.2%. This is the first report on the isolation of methoxylated flavonoid from P. abbreviatum. The high variants of flavonoid compounds from this species may be used as chemotaxonomic markers for this Piper species. KEY WORDS: Piperaceae, Piper, Piper abbreviatum, Flavonoid, Acetylcholinesterase Bull. Chem. Soc. Ethiop. 2020, 34(3), 625-632. DOI: https://dx.doi.org/10.4314/bcse.v34i3.17

show abstract

Antimicrobial activity of tiger's betel (Piper porphyrophyllum N.E. Br., Piperaceae)

Abstract: The ethanol extract of leaves of Piper porphyrophyllum N.E. Br. showed a broad spectrum of antibacterial activity. The activity was increased on fractionation (hexane, dichloromethane and aqueous), particularly in the aqueous fraction. No activity was shown against tested Candida albicans.

Cited by 4 publications

References 1 publication

Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen

Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen

Goniothalamus Species: A Source of Drugs for the Treatment of Cancers and Bacterial Infections?

Chemical constituents and acetylcholinesterase inhibitory activity of Piper abbreviatum Opiz

Contact Info

Product

Resources

About