Antimicrobial activity of tigecycline tested against organisms causing community-acquired respiratory tract infection and nosocomial pneumonia

Fritsche, Thomas R.; Sader, Hélio S.; Stilwell, Matthew G.; Dowzicky, M.; Jones, Ronald N.

doi:10.1016/j.diagmicrobio.2005.05.004

Cited by 73 publications

(52 citation statements)

References 30 publications

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“…Susceptibility to CO was reported as 97.9-100% in various studies. [15][16][17] However, poor pharmacokinetic properties and adverse effects such as nephrotoxicity and neurotoxicity limit its wide clinical usage. 18 Although CO was recommended in salvage therapy of nosocomial MDR-A.…”

Section: Discussionmentioning

confidence: 99%

“…in various studies. 6,15,16 However, there are some reports showing high TIG resistance among A. baumannii isolates without clonal relationship. 21,22 A previous study in our hospital revealed that 25% of the MDR-A.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, MIC levels were higher than in previous studies. 6,15,16 Although 8% of the isolates were resistant to TIG, increased MIC levels (intermediate) were detected in 36% of the isolates. The increased MIC levels of TIG in these strains are worrisome, as TIG may not be adequate in the treatment in monotherapy.…”

Section: Discussionmentioning

confidence: 99%

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In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

et al. 2009

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The emergence of extensive drug-resistant (XDR) Acinetobacter baumannii limits the therapeutic options and leads to high mortality in intensive care units. Combined antibiotic therapy is frequently recommended for the treatment of these infections. Colistin (CO) and tigecycline (TIG), alone or in combination with other antimicrobials, are the most commonly used antibiotics in the treatment of these resistant infections. In this study, the in vitro synergistic activity of TIG and CO were tested for 25 XDR-A. baumannii strains isolated from ventilator-associated pneumonia by the Etest method. Resistance to CO was not detected, whereas 8% of the strains were resistant to TIG. The TIG-CO combination was more synergistic than TIG-rifampin and CO-rifampin according to the fractional inhibitory concentration index. No antagonism was detected between the drugs in the study. There was no strong correlation between the activity of the combinations with reference to strains or genotypes. Our results suggest that the combined use of TIG and CO may be useful for the treatment of XDR-A. baumannii infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

et al. 2009

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“…Nevertheless, tigecycline clearly displays inhibitory activity against Acinetobacter spp. (2,8,9,13,17,19,22,23) and has been utilized for therapy against MDR strains despite the lack of a U.S. FDAapproved clinical indication and interpretive criteria for in vitro susceptibility testing (5, 5a, 11, 13 (24) and tested for susceptibility by CLSI methods (3-5) using freshly prepared (Ͻ12-h-old) cation-adjusted Mueller-Hinton medium (2, 21) for frozen-form broth microdilution tests (TREK Diagnostics, Cleveland, Ohio). Tigecycline disks were used (15 g; lot no.…”

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confidence: 99%

Multicenter Studies of Tigecycline Disk Diffusion Susceptibility Results for Acinetobacter spp

et al. 2007

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Acinetobacter sp. isolates having multidrug resistance (MDR) patterns have become common in many medical centers worldwide, limiting therapeutic options. A five-center study tested 103 contemporary clinical Acinetobacter spp., including MDR strains, by reference broth microdilution and disk diffusion (15-g disk content) methods against tigecycline. Applying U.S. Food and Drug Administration tigecycline breakpoint criteria for Enterobacteriaceae (susceptibility at <2 g/ml [<1 g/ml by the European Committee on Antimicrobial Susceptibility Testing]; disk diffusion breakpoints at >19 mm and <14 mm) to Acinetobacter spp. led to an unacceptable error rate (23.3%). However, an adjustment of tigecycline disk diffusion breakpoints (susceptible/resistant) to >16/<12 mm reduced intermethod errors to an acceptable level (only 9.7%, all minor).

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“…Haemophilus influenzae (Fritsche et al 2005) are common bacteria known to cause respiratory diseases.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Essential Oil from Abies holophylla against Respiratory Tract Bacteria

Lee¹,

Kim²,

Park³

et al. 2014

Journal of the Korean Wood Science and Technology

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We extracted essential oils from four species (Pinus densiflora, Larix kaempferi, Pinus koraiensis, and Abies holophylla) in the family Pinaceae to investigate their antibacterial activities against respiratory tract bacteria (Klebsiella pneumoniae, Haemophillus influenzae, Streptococcus pyogenes, Streptococcus pneumonia, and Neisseria meningitides). Among the tested oils, that from A. holophylla was showed strong activity based on disc diffusion and broth medium dilution (minimum inhibitory concentration, MIC) assays. Qualitative analysis of A. holophylla oil was carried out by GC-MS; α -pinene, camphene, β -pinene, 3-carene, limonene, bornyl acetate, borneol, β -caryophyllene, α -caryophyllene, caryophyllene oxide, and α -bisabolol were identified as its major constituents. Fractionation by silica gel chromatography was performed to analyze the active constituents of the crude oil. In particular, one fraction containing caryophyllene oxide as the major constituent showed stronger antibacterial activity than the crude oil of A. holophylla. Growth rates of bacterial strains exposed to fraction D were explored by optical density (OD600) measurements while morphology was examined by optical microscopy observations (× 1000). OD600 of K. pneumoniae decreased from 0.2582 to 0.005 in response to treatment with fraction D at a MIC value of 0.31 μ ℓ /mℓ .

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Antimicrobial activity of tigecycline tested against organisms causing community-acquired respiratory tract infection and nosocomial pneumonia

Cited by 73 publications

References 30 publications

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

Multicenter Studies of Tigecycline Disk Diffusion Susceptibility Results for Acinetobacter spp

Antibacterial Activity of Essential Oil from Abies holophylla against Respiratory Tract Bacteria

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