Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae)

Kuete, Victor; Wabo, Ghislain Fotso; Ngameni, Bathélémy; Mbaveng, Armelle T.; Metuno, Robert; Etoa, François–Xavier; Ngadjui, Bonaventure T.; Beng, Véronique Penlap; Meyer, J.J.M.; Lall, Namrita

doi:10.1016/j.jep.2007.07.025

Cited by 101 publications

(78 citation statements)

References 22 publications

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“…Poor activity of OA against Klebsiella pneumoniae [31], E. coli and other Gramnegative bacteria [44], and several clinical isolates of Pseudomonas aeruginosa [21] have been reported (Table 1). Cai and Wu were unable to identify any activity of OA isolated from a methanol extract of the clove Syzygium aromaticum (Myrtaceae) against the Gram-negative anaerobic periodontal pathogens Porhyromonas gingivalis and Prevotella intermedia or the Gram-positive cariogenic oral bacteria S. mutans and Actinomyces viscosus [45].…”

Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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Bacterial resistance to antibiotics is increasing at an alarming rate and many commonly used antibiotics are no longer effective.Thus, there is considerable interest in investigating novel antibacterial compounds, such as the plant-derived pentacyclic triterpenoids, including oleanolic acid (OA), ursolic acid (UA) and their derivatives. These compounds can be isolated from many medicinal and crop plants and their antibacterial, antiviral, antiulcer and anti-inflammatory effects are well documented. OA and UA are active against many bacterial species, particularly Gram-positive species, including mycobacteria. They inhibit bacterial growth and survival, and the spectrum of minimal inhibitory concentration (MIC) values is very broad. In addition, OA, UA and their derivatives display potent antimutagenic activity. Studies to identify the cellular targets and molecular mechanisms of OA and UA action were initiated a few years ago and it has already been demonstrated that both acids influence bacterial gene expression, the formation and maintenance of biofilms, cell autolysis and peptidoglycan turnover. Before these compounds can be used clinically as antimicrobial agents, further extensive studies are required to determine their cytotoxicity and the optimum mode of their application.

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Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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“…Earlier studies on the antimicrobial activity of different species of Dorstenia, for example, the twigs of D. angusticornis (Kuete et al, 2007a) has revealed that most of the bacteria used above showed sensitivity when tested with the extracts of the twigs of Dorstenia angusticornis. Antibacterial properties are the ability of a drug or a plant extract to stop a bacterium from growing, …”

Section: Discussionmentioning

confidence: 99%

“…Research has been carried out by (Kuete et al, 2007a;Ngameni et al, 2007) on the antimicrobial properties on many genus of Dorstenia but findings have very little studies on the antibacterial properties of D. Mannii.…”

Section: Introductionmentioning

confidence: 99%

“…The twigs of Dorstenia elliptica have been tested for their in vitro antimicrobial activity against bacteria and fungi ( Kuete et al, 2007c). Outside these activities observed from this genus, traditional pharmacopoeia reveals other particular activities of certain species, such as anti-diabetic, anticholesterol, anti-oxidant and anti-malarial properties (Kuete et al, 2007a). Thus the leaves of Dorstenia multiradiata are used in Nigeria for their antimolluscidale activity (Haerdi, 1964).…”

Section: Introductionmentioning

confidence: 99%

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In-vitro evaluation of the anti-bacterial properties of crude extracts of Dorstenia mannii (Moraceae)

Fokunang¹,

Mejane²,

Noumie³

et al. 2012

J. Microbiol. Antimicrob.

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Bacterial resistance to classical antibiotics nowadays is becoming a health concern in Cameroon. Patients suffering from bacteria attack spend money to carry out laboratory tests for effective diagnosis, with very little positive results. This is due to the fact that most of our hospitals lack the up to date laboratory equipments, to detect the real antibiotic that will kill a particular bacterium. This has led to more patients spending a lot of money on bacterial infection treatment, and some even end up dying with the disease. It is on this basis that this work was designed to research the antibacterial properties of the extracts namely crude extract, hexane-acetate 25%, hexane-acetate 50%, hexaneacetate 75%, hexane, acetate and methanol of the leaves of Dorstenia mannii, a plant that is readily available from our natural environment at little or no cost. These extracts were tested on the following bacteria species namely; Gram-negative bacteria; Enterobacter aerogenes, Escherichia coli, Klebsiella sp., Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica; Gram-positive bacteria; Staphylococcus aureus and Bacillus sp. After some laboratory analysis using the antibiogramme sensitivity test, it was discovered that the extracts of the leaves of D. mannii were only sensitive on three of the eight bacteria used which were, E. coli, S. enterica and Klebsiella sp. The other five namely; P. aeruginosa, E. aerogenes, P. mirabilis, S. aureus and Bacillus sp, were resistant to the extract. The sensitivity level of the three bacteria, that showed positive response where however low. Therefore, more research has to be carried out using different concentrations of the leaves extract for a more conclusive result. This concentration could permit to appreciate the degree of sensitivity and also to see if other bacteria that have not manifested any sensitivity can show some positive response to the extracts. Also, different laboratory methods and more bacteria should be used to prove that the leaves of D. mannii have the potential as a promising antibacterial medicinal plant to either render bacteria inactive or kill them completely.

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“…[33][34][35] As examples, isolated compounds such as gallic acid from Caesalpinia mimosoides showed activity against Salmonella typhi and Staphylococcus aureus, 36 ellagic acid derivatives from Irvingia gabonensis showed activity against bacteria and fungi, 37 and flavonoid derivatives of Pericarpium Citri Reticulatae showed activity against E. coli, S. typhi, and Staphylococcus epidermidis. 38 The results of the antimicrobial tests showed that the diarrhea agents E. faecalis, E. coli, Salmonella sp., and S. sonnei are weakly sensitive to fruit and leaf extracts of P. cauliflora.…”

Section: Figmentioning

confidence: 99%

Chemical and Antidiarrheal Studies ofPlinia cauliflora

Souza-Moreira

Severi

Santos

et al. 2011

Journal of Medicinal Food

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Plinia cauliflora (Mart.) Kausel, widespread in South America, has edible fruits, and its bark is commonly used against diarrhea and other disorders, on account of its astringency. Because diarrhea is still one of the most important causes of illness and death among children in developing countries, where the population turns to traditional medicine for its treatment, the present study determined the composition of fruit and leaf extracts of P. cauliflora, analyzed the activity against diarrhea by antimicrobial and gastrointestinal motility, and evaluated the cytotoxicity of the extracts. Chemical composition was determined by high-performance liquid chromatograpy-ultraviolet/photodiode array detection. Antimicrobial activity was analyzed by agar diffusion and the microdilution method against etiological agents of diarrhea. The effect on gastrointestinal motility was analyzed using an experimental model in mice. Cytotoxicity was evaluated in vitro with the fibroblast cell line SIRC CCL 60, and leaf extract showed a 50% inhibitory concentration of 0.48 lg/mL. Gallic acid, ellagic acid, and flavonoid derivatives were detected in the extracts. It was observed that fruit and leaf extracts showed some activity against Enterococcus faecalis, Escherichia coli, Salmonella sp., and Shigella sp. However, neither extract had any effect on gastrointestinal motility.

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Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae)

Cited by 101 publications

References 22 publications

Antibacterial activity of oleanolic and ursolic acids and their derivatives

Antibacterial activity of oleanolic and ursolic acids and their derivatives

In-vitro evaluation of the anti-bacterial properties of crude extracts of Dorstenia mannii (Moraceae)

Chemical and Antidiarrheal Studies ofPlinia cauliflora

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