Antimicrobial Activity of the Dichloromethane Extract from <i>in vitro</i> Cultured Roots of <i>Morinda royoc</i> and Its Main Constituents

Borroto, Janetsy; Salazar, Ricardo; Pérez, Alejandro; Quirós, Yemeys; Hernández, Martha; Waksman, Noemí; Sánchez, Reinaldo Trujillo

doi:10.1177/1934578x1000500526

Cited by 2 publications

(2 citation statements)

References 5 publications

(6 reference statements)

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“…The inhibitory effect of morindone on HCT116 cell proliferation was also reported in work by [23]. Other than that, morindone also demonstrated strong antimicrobial activity against C. lipolytica [46] and oxacillinresistant Staphylococcus aureus [47].…”

Section: Plos Onesupporting

confidence: 69%

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Morindone from Morinda citrifolia as a potential antiproliferative agent against colorectal cancer cell lines

et al. 2022

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There is an increasing demand in developing new, effective, and affordable anti-cancer against colon and rectal. In this study, our aim is to identify the potential anthraquinone compounds from the root bark of Morinda citrifolia to be tested in vitro against colorectal cancer cell lines. Eight potential anthraquinone compounds were successfully isolated, purified and tested for both in-silico and in-vitro analyses. Based on the in-silico prediction, two anthraquinones, morindone and rubiadin, exhibit a comparable binding affinity towards multitargets of β-catenin, MDM2-p53 and KRAS. Subsequently, we constructed a 2D interaction analysis based on the above results and it suggests that the predicted anthraquinones from Morinda citrifolia offer an attractive starting point for potential antiproliferative agents against colorectal cancer. In vitro analyses further indicated that morindone and damnacanthal have significant cytotoxicity effect and selectivity activity against colorectal cancer cell lines.

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Section: Plos Onesupporting

confidence: 69%

“…Other than that, morindone also demonstrated strong antimicrobial activity against C . lipolytica [ 46 ] and oxacillin-resistant Staphylococcus aureus [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Morindone from Morinda citrifolia as a potential antiproliferative agent against colorectal cancer cell lines

et al. 2022

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A Morinda royoc Root Extract and Fractions Exhibit Antigiardial Activity without Affecting Cell Viability

Quintal-Novelo¹,

Valencia-Chan²,

Chávez‐González³

et al. 2022

IJPA

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Background: The gastrointestinal parasite Giardia lamblia causes giardiasis. Its treatment with standard drugs produces side effects and improper treatment can generate resistant strains. New antigiardial compounds are needed. An analysis was done to identify the antigiardial activity of Morinda royoc, a plant used in traditional Mayan medicine to treat stomach and bowel pain. We aimed to assess the efficacy of M. royoc roots against G. lamblia and their effect on cells viability. Methods: A methanol extract was done of the root and then fractionated. The extract and fractions were tested in vitro on G. lamblia trophozoites and their effect on cell viability was quantified by flow cytometry. The active extract and fractions were analyzed by gas chromatography–mass spectrometry and high-performance liquid chromatography. Results: The hexane fraction exhibited potent activity against G. lamblia (IC50 = 0.08 µg/mL). Its principal component was an anthraquinone-type compound. None of the fractions were toxic to human promyelocytic leukemia, chronic myelogenous leukemia and human mononuclear cells. Conclusion: The medicinal plant M. royoc contains promising bioactive agents with antigiardial activity and deserves further research.

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Antimicrobial Activity of the Dichloromethane Extract from in vitro Cultured Roots of Morinda royoc and Its Main Constituents

Cited by 2 publications

References 5 publications

Morindone from Morinda citrifolia as a potential antiproliferative agent against colorectal cancer cell lines

Morindone from Morinda citrifolia as a potential antiproliferative agent against colorectal cancer cell lines

A Morinda royoc Root Extract and Fractions Exhibit Antigiardial Activity without Affecting Cell Viability

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