Antimicrobial activity of secondary metabolite compounds from lichen Teloschistes flavicans

Abstract

Exploration of lichen natural compounds has attracted a lot of attention from researchers as potential medicinal raw materials because chemical compounds contained in lichen have many properties. The potential for developing secondary metabolite compounds of lichen has become a trend for various benefits, for example, in cosmetics, agriculture, health, and food. Lichen Teloschistes flavicans was a concern to study because there were not many reports of secondary metabolites that have antimicrobial activity. The research objective was to examine antimicrobial activity using 3-[1’-(2”,3”-dihydroxy-phenyl)-propyl]-7hydroxy-chroman-4-one compound from lichen Teloschistes flavicans. The antimicrobial activity test was a well diffusion method. Bioactivity was determined by calculating the clear zone formed around the well. Antimicrobial activity testing indicated the inhibition of bacterial growth at a concentration of 500 ppm and 1000 ppm with the respective inhibition zones namely E. coli (10-11 mm), S. Typhi (2-5 mm), K. pneumoniae (11-13 mm), and S. aureus (10-13 mm). Also, B. cereus bacteria and C. albicans fungi were only inhibited at a concentration of 1000 ppm with an inhibition zone of 6 mm each. This research provides scientific knowledge about the potential development of lichen T. Flavicans as an antimicrobial.

A review of the potential of lichen substances as antifungal agents: the effects of extracts and lichen secondary metabolites on Fusarium fungi

“…Laboratory in vitro studies on the potential of lichen secondary metabolites report their broad biological properties such as anticancer (Cardile et al 2017 ; Tripathi et al 2022 and literature cited therein), antioxidant (Hawrył et al 2020 ; Maulidiyah et al 2021 ), antimicrobial (Shiromi et al 2021 ; Sargsyan et al 2021 ), pro-health (Zhao et al 2021 and literature cited therein) or anti-fusarial potentials described in this meta-analysis.…”

Potential of Usnic Acid Compound from Lichen Genus <i>Usnea</i> sp. as Antidiabetic Agents

“…Usnea sp. is one of the genus of lichen that produces secondary metabolites, which are known to have many pharmacological activities as antibacterial 9,10) , antiprotozoal 11) , anticytotoxic 12) , antiproliferative 13) , antioxidant 13) , and antiinflammatory 14) . celastri, R. nervulosa 25) , Caloplaca biatorina 26) , Cladonia sp.…”

“…Based on our previous study, the lichen Usnea sp. contains secondary metabolites such as 2'-hydroxy-1'-(4-hydroxyl-5-methoxy-2-methyl-phenyl) -etone 30) , 3-［1'-(2",3"-dihydroxyphenyl) -propyl］ -7-hydroxy-chroman-4-one 31) , (5E,6E) 5-ethylidene-7-formyl-6,7-hydroxymethylhept-6-enoate 32) , eumitrin A1 33) , atranorin 6) , and diffractaic acid 8) . Isolation, structural elucidation, and inhibition test of the α-glucosidase enzyme of a usnic acid compound from lichen genus Usnea sp.…”