Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae)

Gehrke, Ilaine Teresinha Seibel; Neto, Alexandre T.; Pedroso, Marcelo; Mostardeiro, Clarice Pinheiro; Cruz, Ivana Beatrice Mânica da; Silva, Ubiratan F.; Ilha, Vinícius; Dalcol, Ionara I.; Morel, Ademir F.

doi:10.1016/j.jep.2013.04.043

Cited by 65 publications

(37 citation statements)

References 26 publications

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“…[32]. Thus a broad spectrum of antibacterial activity is envisaged; as also reported by Gehrke et al, [33] for Schinus lentiscifolius extracts.…”

Section: Antimicrobial Activitymentioning

confidence: 65%

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

Padalia¹,

Ch²

2015

Appli Micro Open Access

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Bacteria have evolved numerous defences against antimicrobial agent and drug resistance in pathogen is on rise. This is due to rapid development of multi-drug resistance, limited anti-bacterial spectrum and adverse effects of available anti-microbial agents. This necessitates the search for new antimicrobials with diverse structures and novel mechanism of action. Flowers are mostly used for ornamental purposes and they are not frequently worked out hence marigold flower was selected for the study. The antimicrobial activity of different solvent (Hexane, Toluene, Ethyl acetate, Acetone, Methanol and Aqueous) extracts of marigold flowers were evaluated by agar well diffusion method against a panel of pathogenic microorganisms. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of acetone extract and its fraction were evaluated. B. cereus and K. pneumonia were the most sensitive organisms to acetone extract and minimum inhibitory concentration (MIC) was 78 µg/ml. Synergistic effect of acetone extract and commercial antibiotics (chloroamphenicol and ceftazidime) against pathogenic bacteria was investigated. The best synergistic activity was with combination of acetone extract and ceftazidime against B. subtilis and P. aeruginosa with FIC indices 0.312 and 0.093 respectively. Only the polar solvent acetone extract showed promising antibacterial and synergistic activity. These results indicate that combination between plant extract and the antibiotics could be useful in fighting emerging drug-resistant microorganisms and choice of the solvent plays a prominent role in evaluating antimicrobial activity of medicinal plants. Flowers can be taken as an alternative source of antimicrobial agent against the human pathogens.

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“…[32]. Thus a broad spectrum of antibacterial activity is envisaged; as also reported by Gehrke et al, [33] for Schinus lentiscifolius extracts.…”

Section: Antimicrobial Activitymentioning

confidence: 65%

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

Padalia¹,

Ch²

2015

Appli Micro Open Access

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“…The 96-well microplate was placed in a Spectra Max M2 and OD of cell cultures containing test samples and antibiotic were read after 10 h of incubation. Technical data have been described previously [33], [34].…”

Section: Methodsmentioning

confidence: 99%

Structure-Activity Relationship of Benzophenanthridine Alkaloids from Zanthoxylum rhoifolium Having Antimicrobial Activity

et al. 2014

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Zanthoxylum rhoifolium (Rutaceae) is a plant alkaloid that grows in South America and has been used in Brazilian traditional medicine for the treatment of different health problems. The present study was designed to evaluate the antimicrobial activity of the steam bark crude methanol extract, fractions, and pure alkaloids of Z. rhoifolium. Its stem bark extracts exhibited a broad spectrum of antimicrobial activity, ranging from 12.5 to 100 µg/mL using bioautography method, and from 125 to 500 µg/mL in the microdilution bioassay. From the dichloromethane basic fraction, three furoquinoline alkaloids (1–3), and nine benzophenanthridine alkaloids (4–12) were isolated and the antimicrobial activity of the benzophenanthridine alkaloids is discussed in terms of structure-activity relationships. The alkaloid with the widest spectrum of activity was chelerythrine (10), followed by avicine (12) and dihydrochelerythrine (4). The minimal inhibitory concentrations of chelerythrine, of 1.50 µg/mL for all bacteria tested, and between 3.12 and 6.25 µg/mL for the yeast tested, show this compound to be a more powerful antimicrobial agent when compared with the other active alkaloids isolated from Z. rhoifolium. To verify the potential importance of the methylenedioxy group (ring A) of these alkaloids, chelerythrine was selected to represent the remainder of the benzophenanthridine alkaloids isolated in this work and was subjected to a demethylation reaction giving derivative 14. Compared to chelerythrine, the derivative (14) was less active against the tested bacteria and fungi. Kinetic measurements of the bacteriolytic activities of chelerythrine against the bacteria Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) were determined by optical density based on real time assay, suggesting that its mechanism of action is not bacteriolytic. The present study did not detect hemolytic effects of chelerythrine on erythrocytes and found a protective effect considering the decrease in TBARS and AOPP (advanced oxidized protein products) levels when compared to the control group.

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“…For example, n-nonadecanol from Schinus lentiscifolius, 185 lupeol from Albizia adianthifolia, 186 genisstein from soybean (Glycine max), 187 geraldone from Flourensia oolepis, 188 and liquiritigenin from Dalbergia odorifera. (Figure 2) from the methnolic extract of Carob leaves.…”

Section: Discussionmentioning

confidence: 99%

CAROB (Ceratonia siliqua): HEALTH, MEDICINE, CHEMISTRY

Azab¹

2017

ECB

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Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae)

Abstract: The antimicrobial activity and some constituents of Schinus lentiscifolius are reported for the first time. The results of the present study provide scientific basis for the popular use of Schinus lentiscifolius for a number of different health problems.

Cited by 65 publications

References 26 publications

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

Structure-Activity Relationship of Benzophenanthridine Alkaloids from Zanthoxylum rhoifolium Having Antimicrobial Activity

CAROB (Ceratonia siliqua): HEALTH, MEDICINE, CHEMISTRY

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