Antimicrobial activity of ropivacaine and other local anaesthetics

Abstract

Ropivacaine had no antimicrobial effect on microorganisms tested. Bupivacaine showed poor antimicrobial effectiveness. Lidocaine and prilocaine had more powerful antimicrobial effects than the other two local anaesthetics.

Antibacterial Properties of 2% Lidocaine and Reduced Rate of Endophthalmitis After Intravitreal Injection

“…[5][6][7] Moreover, similar to povidone-iodine, its nonselective mechanism of action makes it less susceptible to resistance, which gives it a distinct clinical advantage over antibiotics. Previous studies have shown that lidocaine possesses broad inhibitory effects against a wide spectrum of microorganisms including gram-positive, gram-negative, mycobacteria, and fungal organisms.…”

“…1 Recommended preventative measures include application of povidone-iodine and strict aseptic technique using a lid speculum. [5][6][7] Previous studies have shown that lidocaine inhibits gram-positive and gram-negative bacteria, mycobacteria, and fungi. [5][6][7] Previous studies have shown that lidocaine inhibits gram-positive and gram-negative bacteria, mycobacteria, and fungi.…”

Antimicrobial effect of anesthetic‐eluting ultra‐high molecular weight polyethylene for post‐arthroplasty antibacterial prophylaxis

“…For instance, Aydin et al demonstrated pronounced antimicrobial properties of 0.5% lidocaine against S. aureus, while bupivacaine failed to inhibit bacterial growth. 18 In contrast, other studies showed that bupivacaine possesses higher antibacterial activity against S. aureus when compared with lidocaine. 19,37 The observed discrepancy between the results is likely due to the lack of consistency among the experimental protocols used to evaluate antibacterial activity.…”

“…17 Our approach is based on previous studies demonstrating antibacterial activity of pain medications including opioids, non-steroidal anti-inflammatory drugs, and amide-type local anesthetics. [18][19][20][21][22][23][24] Of particular importance are sodium-channel blockers such as lidocaine, ropivacaine, bupivacaine, prilocaine, and mepivacaine,…”

Synthesis, antimicrobial and QSAR studies of substituted anilides

“…Recently substituted anilides have received considerable attention due to their wide range of biological activities viz. antibacterial, antifungal, anticonvulsant, anaesthetic, antiproliferative, antiplaque, antiplatelet-aggregation, antioxidant and potassium channel activating potentials [4][5][6][7][8][9][10][11][12][13] .…”