Antimicrobial activity of Plectranthus barbatus (Lamiacea)

Veríssimo, Regina Célia Sales Santos; Lins, Thaís Honório; Bastos, Maria Lysete de Assis; Sarmento, Patrícia de Albuquerque; Alvino, Valter; Araújo, Maria Gabriella Silva; Silva, Andressa Letícia Lopes; Araújo-Júnior, João Xavier de

doi:10.1186/1753-6561-8-s4-p264

Cited by 5 publications

(2 citation statements)

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“…Pogonomyrmex barbatus Andrews was reported to remedy chest problems and skin diseases and has been proven to possess antimicrobial and antioxidant activities [32,33]. The popularity and the diverse medicinal uses of P. barbatus Andrews as reported in this study may be due to the presence of bioactives with a wide range of pharmacological activities such as forskolin-a labdane diterpenoid that occurs in P. barbatus Andrews.…”

Section: Quantitative Analysis and The Significance Of The Fc Uv And ...mentioning

confidence: 65%

Ethnobotanical survey of the medicinal plants used in Kakamega County, western Kenya

Odongo¹

2018

Appl Med Res

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Aim: This study was carried out to identify the medicinal plants used by the Luhya community in Kakamega County and promote the preservation of this traditional knowledge. Methods: An ethnobotanical study was carried out between March 2016 and April 2016. Information from the 26 participants was obtained through face-to-face interviews, field observations, and by the use of semi-structured questionnaires. A literature review was done to identify the previously reported traditional uses and pharmacological activities. The relative frequency of citation, use values, and fidelity level values of the reported medicinal plants were calculated.

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Section: Quantitative Analysis and The Significance Of The Fc Uv And ...mentioning

confidence: 65%

Ethnobotanical survey of the medicinal plants used in Kakamega County, western Kenya

Odongo¹

2018

Appl Med Res

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“…Araújo et al (2019) identified the antifungal activity of ethanol extract of P. barbatus leaves against species involved in invasive fungal disease and showed the greatest MIC values against Candida glabrata (31.2 µg.mL -1 ), Saccharomyces cerevisiae, Rhodotorula mucilaginosa, Candida krusei, Candida parapsilosis and Candida gattii (all with MIC = 62.5 µg.mL -1 ), that the methanolic extract showed activity against all Gram-positive isolates. However, Santos Veríssimo et al (2014) identified the antibacterial activity of the crude ethanol extract of P. barbatus leaves against E. coli showing a MIC = 6250 µg.mL -1 and also against Staphylococcus aureus (MIC = 3120 µg.mL -1 ). Araújo et al (2014) also evaluated the antibacterial action of the leaf extract of P. barbatus, which presented bacteriostatic activity against E. coli (MIC = 250 µg.mL -1, MBC > 2000 µg.mL -1 ) and P. aeruginosa (MIC = 250 µg.mL -1 , MBC = 2000 µg.mL -1 ).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical characterization and biological activities of Plectranthus barbatus Andrews

et al. 2022

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Plectranthus barbatus Andrews (Lamiaceae) is widely distributed in the world and has a range of popular therapeutic indications. This work aimed to evaluate the phytochemical characterization of two leaf extracts of P. barbatus, and their antimicrobial, antineoplastic and immunomodulatory potential. After collection, herborization and obtainment of the P. barbatus aqueous extract (PBA) and acetone:water 7:3 P. barbatus organic extract (PBO), the phytochemical characterization was performed by high-performance liquid chromatography (HPLC). The antimicrobial activity was performed to determine the minimum inhibitory concentration (MIC) against eight bacterial strains using the microdilution test and the fungus Trichophyton rubrum by disc diffusion assay and microdilution test. Cytotoxicity was assessed by MTT and trypan blue methods in normal peripheral blood mononuclear cells (PBMCs) at concentrations ranged between 0.1 to 100 µg.mL-1 and in neoplastic cell lines Toledo, K562, DU-145 and PANC-1 at 1, 10 and 100 µg.mL-1 . Immunomodulatory activity, was evaluated by sandwich ELISA of proinflammatory cytokines at BALB/c mice splenocytes cultures supernatant. Both extracts presented flavonoids, cinnamic derivatives, steroids and ellagic acid. PBO showed bacteriostatic activity against Acinetobacter baumannii (MIC = 250 µg.mL-1) clinical isolate and PBA fungistatic activity against Trichophyton rubrum (MIC = 800 µg.mL-1). The extracts did not exhibit toxicity to PBMCs and neoplastic cells (IC50 > 100 µg.mL-1). Additionally, PBO at 100 µg.mL-1 significantly inhibited IFN-γ and IL-17A cytokines (p = 0.03). Plectranthus barbatus is a potential candidate for therapeutic use due to its low toxicity in healthy human cells and exhibits biological activities of medical interest as bacteriostatic, fungistatic and immunomodulatory.

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Phytopharmaceuticals for Treating Sexually Transmitted Diseases

Ugoeze¹

2022

Herbal Drugs for the Management of Infectious Diseases

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Antimicrobial activity of Plectranthus barbatus (Lamiacea)

Cited by 5 publications

References 3 publications

Ethnobotanical survey of the medicinal plants used in Kakamega County, western Kenya

Ethnobotanical survey of the medicinal plants used in Kakamega County, western Kenya

Phytochemical characterization and biological activities of Plectranthus barbatus Andrews

Phytopharmaceuticals for Treating Sexually Transmitted Diseases

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