Antimicrobial activity of plant extracts against carbapenem-producing <i>Klebsiella pneumoniae</i> and <i>in vivo</i> toxicological assessment

Vasconcelos, Nathalie Gaebler; Vaz, Márcia Soares Mattos; Radai, Joyce Alencar Santos; Kassuya, Cândida Aparecida Leite; Formagio, Anelise Samara Nazari; Graciani, Fernanda Silva; Leal, Maria Lorenza; Oliveira, Rodrigo Juliano; Silva, Késia Esther da; Croda, Júlio; Simionatto, Simone

doi:10.1080/15287394.2020.1824135

Cited by 11 publications

(5 citation statements)

References 43 publications

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“…Z. cassumunar was also shown to exhibit antibacterial effects against Gram-positive bacteria, such as S. aureus, with very low antibacterial activity [33], while it displayed high antimicrobial activity against dermatophytes and yeasts [34]. The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against CRKP, Serratia marcescens, and Acinetobacter baumannii was assessed by the time-kill assays, and a decrease in cell count was observed after 4 h treatment [35].…”

Section: Discussionmentioning

confidence: 99%

Citrus bergamia: Kinetics of Antimicrobial Activity on Clinical Isolates

et al. 2022

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Background: The inappropriate use of antibiotics has increased selective pressure and the spread of multi-drug-resistant (MDR) pathogens, which reduces the possibility of effective treatment. A potential alternative therapeutic approach may be represented by essential oils, such as the distilled extract of bergamot (Citrus bergamia Risso et Poiteau). Such natural products exercise numerous biological activities, including antimicrobial effects. Methods: This work aimed to evaluate the kinetics of the bactericidal and fungicidal activity of the distilled extract of bergamot on MDR bacteria and fungi from clinical specimens using the time-kill assay. Furthermore, the antimicrobial activity of the distilled extract of bergamot on the morphology and cellular organization of clinical pathogens was evaluated by confocal laser scanning microscopy. Results: Our results demonstrated that the distilled extract of bergamot exhibited significant antimicrobial activity and a specific bactericidal effect against the bacterial and fungal strains tested. Furthermore, confocal microscope images clearly showed compromised membrane integrity, damage and cell death in bacterial samples treated with the distilled extract of bergamot. In addition, progressive alterations in cell-wall composition, cytoplasmic material and nucleus structure triggered by exposure to the distilled extract of bergamot were identified in the fungal samples considered. Conclusions: Our data suggest that the use of essential oils, such as distilled extract of bergamot (Citrus bergamia Risso et Poiteau), can represent a valid alternative therapeutic strategy to counteract antibiotic resistance of pathogens.

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Section: Discussionmentioning

confidence: 99%

Citrus bergamia: Kinetics of Antimicrobial Activity on Clinical Isolates

et al. 2022

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“…The most abundant are terpenes (94.19%) as a-pinene, camphene, and eucalyptol (González-Saucedo et al, 2019). In addition, the alcoholic extract exerts antispasmodic, anti-inflammatory, antioxidative, and antimicrobial activities and does not exhibit mutagenic activity and genotoxicity (Bejar et al, 1995;Pompeu et al, 2012;De Souza et al, 2018;Vasconcelos et al, 2020). Also, essential oils inhibit the growth of pathogenic bacteria, including Staphylococcus aureus and Bacillus cereus (Vázquez-Cahuich et al, 2013).…”

Section: Leavesmentioning

confidence: 99%

Byrsonima crassifolia L. Kunth a bio-resource with potential: Overview and opportunities

Martín-Hernández

Martínez-Téllez

Valenzuela-Amavizca

et al. 2023

Folia Horticulturae

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Byrsonima crassifolia L. Kunth is a plant native to the Americas that grows in tropical and subtropical areas. Fresh B. crassifolia fruits are a good source of ascorbic acid and carotenoids and contain volatile compounds such as butyric and caproic acids. Although B. crassifolia is commonly exploited from wild natural ecosystems, it exhibits the potential to become a crop plant. When optimal agronomic management systems support propagation by seed, fruits with more homogeneous characteristics can be produced compared to those obtained from wild or backyard plants. B. crassifolia fruits can be found in local markets in Central and South America. The pulp, peel, and other B. crassifolia fruit components can be processed to make traditional and innovative food products, namely candies, cookies, cakes, candied fruits, ice creams, sorbets, jellies, juices, liqueurs, jams, nectars, pickles, and fruit drinks as an alternative to avoid the waste of overripe fruits. Additionally, the woody fraction of the B. crassifolia tree is used as a source of firewood, as shade, and for constructing living fences. These uses also allow the maximum use of biomass by establishing support for cultivation with the circular economy and strengthening food security. Therefore, this review aims to provide insights into the generation and dissemination of knowledge supporting the development of strategies in the areas of agronomy, postharvest management, and technological processing of B. crassifolia to promote its sustainable use and exploitation.

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“…Therefore, if different areas receive the same level of conservation, they will most likely have uniformity in plant diversity. Moreover, Jiang et al (2007) and Vasconcelos et al (2020) reported that the altitude of different areas, evolutionary lines, and genetic factors also have a countable impact on similarity or variation in plant species diversity across different areas. Having similar plant diversity across the landscape in the same season facilitates honeybees' easy adaptation to areas within a landscape, especially for migratory beekeeping, which in turn ensures continued production of honeybees' products for both revenue accruing and honeybees' conservation, as their survival depends on plants (Carreck et al, 1997;Rodolfo and Irene, 2009)…”

Section: Plant Diversitymentioning

confidence: 99%

Plant Diversity and Honeybees’ Foraging Preferences: An Implication for Honeybees’ Conservation

Rikohe¹,

Mlozi²,

Ngondya³

2023

EEC

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Identification of honeybees’ preferred plant species is paramount for sustainable conservation, especially when honeybees are reported to be declining globally. The study assessed plant diversity in potential beekeeping areas in Northern Tanzania and determined the foraging preferences of honeybees across two rainy seasons of 2021/2022. We established quadrats of 5 x 5m (shrubs and forbs) nested with 1x1 m (grasses) at each of the four transects of 5 km distance to assess plant diversity and identify the most preferred plants in two study areas. The dominant plant families were Poaceae, Malvaceae, Commelinaceae, Acanthaceae, Amaranthaceae, Polygonaceae, Asteraceae, and Lamiaceae. There was a significant difference in plant diversity between short and long rain seasons in both study areas (t = 2.60, p = 0.01, and t = 2.27, p= 0.03). Grewia bicolor, Terminalia brownii, Ziziphus mucronata, Combretum schumannii, and Cordia monoica were the most visited plants by 2761, 2528, 1966, 1163, and 662 visits, respectively, during the short rain season, while Acacia mellifera, Hoslundia opposita, Ocimum bacilicum and Acalypha fruticosa were the most visited plant species by 1638, 788, 340, and 38 visits, respectively, during the long raing season. This study has highlighted important information on honeybees’ foraging preferences and their diversity that shades a way for sustainable honeybees’ conservation in the area and elsewhere. We recommend further identification and re-planting of honeybees’ forages; awareness campaign to enlighten local people in beekeeping potential areas on the impact of activities that reduce plant diversity, negatively affecting honeybees.

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Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment

Cited by 11 publications

References 43 publications

Citrus bergamia: Kinetics of Antimicrobial Activity on Clinical Isolates

Citrus bergamia: Kinetics of Antimicrobial Activity on Clinical Isolates

Byrsonima crassifolia L. Kunth a bio-resource with potential: Overview and opportunities

Plant Diversity and Honeybees’ Foraging Preferences: An Implication for Honeybees’ Conservation

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