Antimicrobial Activity of Phenolic Constituents of Magnolia Grandiflora L.

Clark, Alice M.; El-Feraly, Arouk S.; Li, Wen-Shyong

doi:10.1002/jps.2600700833

Cited by 206 publications

(116 citation statements)

References 2 publications

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“…The presence of these constituents has been reported to account for the exertion of antimicrobial activity by plants (Clark, 1981;Gonzalel and Mather, 1982;Lutterodt et al, 1999;Pretorius and Watt, 2001).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial effects of Balanites aegyptiaca L. Drel. and Moringa oleifera Lam. on Salmonella typhi

Doughari¹,

J²,

Pukuma³

et al. 2007

Afr. J. Biotechnol.

127

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The aqueous and organic leaves extracts of Balanites aegyptiaca and Moringa oleifera traditionally used for the treatment of infectious disease were tested for their activity against Salmonella typhi isolated from blood clot culture using the disc diffusion method. Extracts of B. aegyptiaca demonstrated higher activity (16 mm zone of inhibition) than those of Moringa oleifera (8 mm zone of inhibition) at 100 mg/ml. Of the three solvents used, ethanolic extracts of both plants demonstrated the highest activity, while the aqueous extracts showed the least activity at 100 mg/ml. The activities of these plant extracts were comparable to those of antibiotics, ciprofloxacin, cotrimoxazole and chloramphenicol, commonly used for treating typhoid fever. The antibacterial activity appears to increase when extracts of the two plants were used in combination at 100 mg/ml each (18 mm zone of inhibition). Preliminary phytochemical screening showed that both plant extracts contains saponins, tannins and phenols while only M. oleifera possesses alkaloids and B. aegyptiaca possesses anthraquinones. The antibacterial activities of the extracts on S. typhi was reasonably stable when treated at 4, 30, 60 and 100 o C for 1 h, however it reduces significantly when the pH was altered towards alkalinity.

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Section: Resultsmentioning

confidence: 99%

Antibacterial effects of Balanites aegyptiaca L. Drel. and Moringa oleifera Lam. on Salmonella typhi

Doughari¹,

J²,

Pukuma³

et al. 2007

Afr. J. Biotechnol.

127

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“…Unpublished studies from our laboratory also indicate that oral gavage of 2 mg honokiol per mouse (thrice a week) statistically significantly inhibits the growth of PC-3 xenografts in male nude mice without causing weight loss or any other side effects. 1 The honokiol-mediated suppression of PC-3 xenograft growth correlates with increased apoptosis and the suppression of proliferating cell nuclear antigen and Ki-67 staining in the tumor tissue. 1 Collectively, these results suggest that honokiol should be seriously considered for further clinical investigation to determine its possible chemopreventive and/or therapeutic efficacy against prostate cancer in humans.…”

Section: Discussionmentioning

confidence: 99%

“…1 The honokiol-mediated suppression of PC-3 xenograft growth correlates with increased apoptosis and the suppression of proliferating cell nuclear antigen and Ki-67 staining in the tumor tissue. 1 Collectively, these results suggest that honokiol should be seriously considered for further clinical investigation to determine its possible chemopreventive and/or therapeutic efficacy against prostate cancer in humans.…”

Section: Discussionmentioning

confidence: 99%

Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity

Hahm

Singh

2007

Molecular Cancer Therapeutics

104

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The present study was undertaken to gain insights into the mechanism of cell cycle arrest caused by honokiol, a constituent of oriental herb Magnolia officinalis. The honokiol treatment decreased the viability of PC-3 and LNCaP human prostate cancer cells in a concentrationand time-dependent manner, which correlated with G 0 -G 1 phase cell cycle arrest. The honokiol-mediated cell cycle arrest was associated with a decrease in protein levels of cyclin D1, cyclin-dependent kinase 4 (Cdk4), Cdk6, and/or cyclin E and suppression of complex formation between cyclin D1 and Cdk4 as revealed by immunoprecipitation using anti -cyclin D1 antibody followed by immunoblotting for Cdk4 protein. The honokiol-treated PC-3 and LNCaP cells exhibited a marked decrease in the levels of total and phosphorylated retinoblastoma protein (Rb), which correlated with the suppression of transcriptional activity of E2F1. Exposure of PC-3 and LNCaP cells to honokiol resulted in the induction of p21 (PC-3 and LNCaP) and p53 protein expression (LNCaP). However, small interfering RNA (siRNA) -mediated knockdown of either p21 (PC-3 and LNCaP) or p53 (LNCaP) protein failed to confer any protection against honokiol-induced cell cycle arrest. The honokiol treatment caused the generation of reactive oxygen species (ROS), and the cell cycle arrest caused by honokiol was partially but significantly attenuated in the presence of antioxidant N-acetylcysteine. In conclusion, the present study reveals that the honokiol-mediated G 0 -G 1 phase cell cycle arrest in human prostate cancer cells is associated with the suppression of protein level/phosphorylation of Rb leading to inhibition of transcriptional activity of E2F1. [Mol Cancer Ther 2007; 6(10):2686 -95]

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“…1A) (1,2). HNK has long been known to have antithrombosis, antibacterial and anxiolytic effects (3)(4)(5)(6). However, its antitumor activities have only recently been described.…”

Section: Introductionmentioning

confidence: 99%

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Wolf¹,

O’Kelly

Wakimoto

et al. 2007

Int J Oncol

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Abstract. Honokiol (HNK), a naturally occurring biphenyl, possesses potent antineoplastic and antiangiogenic properties. We investigated the in vitro and in vivo activity of HNK against breast cancer. HNK exhibited potent anti-proliferative activity against breast cancer cell lines and enhanced the activity of other drugs used for the treatment of breast cancer. In vivo, HNK was highly effective against breast cancer in nude mice. We identified two different effects of HNK on breast cancer cells: cell cycle inhibition, observed at lower doses of HNK, and induction of apoptosis, observed at higher doses of the compound. Our data suggest that HNK is a systemically available, non-toxic inhibitor of breast cancer growth and should be examined for clinical applications.

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Antimicrobial Activity of Phenolic Constituents of Magnolia Grandiflora L.

Cited by 206 publications

References 2 publications

Antibacterial effects of Balanites aegyptiaca L. Drel. and Moringa oleifera Lam. on Salmonella typhi

Antibacterial effects of Balanites aegyptiaca L. Drel. and Moringa oleifera Lam. on Salmonella typhi

Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

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