Antimicrobial Activity of Nitric Oxide-Releasing Ti-6Al-4V Metal Oxide

Reger, Nina; Meng, Wilson S.; Gawalt, Ellen S.

doi:10.3390/jfb8020020

Cited by 10 publications

(2 citation statements)

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“…iodine or selenium) [61,62], and organic molecules (e.g. antibiotics, anti-infective peptides, and nitric oxide) [63][64][65] have been proposed. However, the cytotoxicity of released ions toward bone cells limits these approaches [66].…”

Section: Discussionmentioning

confidence: 99%

Surface functionalization of PEEK with silicon nitride

et al. 2020

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Surface roughness, bioactivity, and antibacterial properties are desirable in skeletal implants. We hot-pressed a mix of particulate sodium chloride (NaCl) salt and silicon nitride (β-Si3N4) onto the surface of bulk PEEK. NaCl grains were removed by leaching in water, resulting in a porous PEEK surface embedded with sim15 vol% β-Si3N4 particles. This functionalized surface showed the osteogenic and antibacterial properties previously reported in bulk silicon nitride implants. Surface enhancement of PEEK with β-Si3N4 could improve the performance of spinal fusion cages, by facilitating arthrodesis and resisting bacteria.

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Section: Discussionmentioning

confidence: 99%

Surface functionalization of PEEK with silicon nitride

et al. 2020

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“…Cleavage of the tether results in the release of the antibiotic for bactericidal action. S-nitrosopenicillamine was coupled to a 16-phosphonohexadecanoic acid SAM on a titanium alloy to function as a nitric oxide (NO) donor (Figure 6a) [140]. When E. coli and S. epidermidis were exposed to this SAM, they showed a mild reduction in growth.…”

Section: Sams Promoting Release Of Anti-microbial Agentsmentioning

confidence: 99%

Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation

et al. 2022

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Bacterial infections due to biofilms account for up to 80% of bacterial infections in humans. With the increased use of antibiotic treatments, indwelling medical devices, disinfectants, and longer hospital stays, antibiotic resistant infections are sharply increasing. Annual deaths are predicted to outpace cancer and diabetes combined by 2050. In the past two decades, both chemical and physical strategies have arisen to combat biofilm formation on surfaces. One such promising chemical strategy is the formation of a self-assembled monolayer (SAM), due to its small layer thickness, strong covalent bonds, typically facile synthesis, and versatility. With the goal of combating biofilm formation, the SAM could be used to tether an antibacterial agent such as a small-molecule antibiotic, nanoparticle, peptide, or polymer to the surface, and limit the agent’s release into its environment. This review focuses on the use of SAMs to inhibit biofilm formation, both on their own and by covalent grafting of a biocidal agent, with the potential to be used in indwelling medical devices. We conclude with our perspectives on ongoing challenges and future directions for this field.

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Advances in Antimicrobial Organic and Inorganic Nanocompounds in Biomedicine

Wang

Makvandi

Zare

et al. 2020

Advanced Therapeutics

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Bacterial resistance to antibiotics is an important issue in contemporary society. To date, infection‐related problems persist despite intensive research efforts by chemists and biologists. Much effort has been devoted over the last decade to the development of organic/nonmetallic inorganic nanocompounds with antimicrobial activities for overcoming human infections and illnesses produced by antibiotic‐resistant pathogens. Both organic nanomaterials such as chitosan nanoparticles and conductive‐based polymer nanocompounds, as well as nonmetallic inorganic nanomaterials such as carbon‐based nanocompounds and modified nanoceramics, have been manufactured and employed in medicine for treating multidrug‐resistant infections. This review describes the most recent advances in the biomedical applications of antibacterial organic/nonmetallic inorganic nanocompounds.

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Antimicrobial Activity of Nitric Oxide-Releasing Ti-6Al-4V Metal Oxide

Cited by 10 publications

References 50 publications

Surface functionalization of PEEK with silicon nitride

Surface functionalization of PEEK with silicon nitride

Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation

Advances in Antimicrobial Organic and Inorganic Nanocompounds in Biomedicine

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