Antimicrobial activity of natural and semi-synthetic carbazole alkaloids

“…Due to this, the most advantageous approach is the chemical modification of polymers, i.e., the covalent incorporation of antimicrobial fragments [ 24 ]. The main application areas for antimicrobial polymers are the medicine, textile and food industries [ 25 ]. For example, the use of antimicrobial polymers in the manufacture of medical devices could stop most hospital-acquired infections, which occur because medical devices provide the right conditions for microbes to grow [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Glycerol Acrylate-Based Photopolymers with Antimicrobial and Shape-Memory Properties

Saunoryte,

Navaruckiene,

Grauzeliene

et al. 2024

Polymers

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In this paper, for the first time, photopolymers were synthesized from glycerol acrylates with different numbers of functional groups, 2-hydroxy-3-phenoxypropyl acrylate, glycerol dimethacrylate or glycerol trimethacrylate, without and with the addition of vanillin styrene. The photocuring kinetics were monitored by real-time photorheometry. The mechanical, rheological, thermal, antimicrobial and shape-memory properties of the photopolymers were investigated. All polymers synthesized demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as antifungal activity against Aspergillus flavus and Aspergillus niger. 2-Hydroxy-3-phenoxypropyl acrylate-based polymers showed thermoresponsive shape-memory behavior. They were able to maintain their temporary shape below the glass transition temperature and return to their permanent shape above the glass transition temperature. Synthesized photopolymers have potential to be used as sustainable polymers in a wide range of applications such as biomedicine, photonics, electronics, robotics, etc.

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“…[8,9,10] Alkaloids, as a type of natural product, are among the most fundamental organic substances engaged in critical physiological functions and may be found in plants, animals, and microbes. They exhibit a wide range of biological activities, [11] including anticancer, antibacterial, and antiviral properties, which is a prevalent issue in current study. Pyrido [4,3-b]carbazole alkaloid derivative (PCAD), such as janetine, olivacine, strellidimine and ellipticine are key components of hetero-annulated carbazoles and have significant biological implementation.…”

Section: Introductionmentioning

confidence: 99%

Deciphering Preferential Binding Interaction of Synthetic Pyrido[2,3‐c]Carbazole Alkaloid Derivative (PCAD) with Pu24T G‐quadruplex DNA

Pal,

Bag,

Burman

et al. 2024

ChemistrySelect

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G‐quadruplex DNA (GQ‐DNA) represents one of the most significant non‐canonical nucleic acid configurations. GQ‐DNA producing sequences are found in different important genomic areas, including the promoter islands of numerous oncogenes and human telomere regions. Therefore, GQ‐DNA is a key target for anticancer medicines. GQ‐DNA has a highly variable structure, it is critical to develop ligand molecules that selectively target certain quadruplex sequences. Natural products such as pyridocarbazole alkaloids have grown interest for healthcare and medicinal values and they considered as a valuable source of innovative anticancer medicines among the chemical compounds. In this investigation, we have synthesised and characterized pyrido[2,3‐c]carbazole derivative (PCAD) through NMR and IR spectra and explore the interactions between PCAD and Pu24T GQ (promoter region), h‐TELO GQ (telomere region) and duplex DNA by employing several multi‐spectroscopic analytical techniques. We have found that PCAD preferentially interacts with Pu24T GQ DNA as compared to other DNA sequences. These findings highlights PCAD as an appealing option for targeting the Pu24T promoter region and consequently acting as an anti‐cancer drug. This study also highlights the potential for developing drugs to understand the molecular aspects of GQ DNA recognition and signaling, paving the way for future research on GQ biology.

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Antimicrobial activity of natural and semi-synthetic carbazole alkaloids

Cited by 16 publications

References 159 publications

N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp³)–H acylation

N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp³)–H acylation

Glycerol Acrylate-Based Photopolymers with Antimicrobial and Shape-Memory Properties

Deciphering Preferential Binding Interaction of Synthetic Pyrido[2,3‐c]Carbazole Alkaloid Derivative (PCAD) with Pu24T G‐quadruplex DNA

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Antimicrobial activity of natural and semi-synthetic carbazole alkaloids

Cited by 16 publications

References 159 publications

N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp3)–H acylation

N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp3)–H acylation

Glycerol Acrylate-Based Photopolymers with Antimicrobial and Shape-Memory Properties

Deciphering Preferential Binding Interaction of Synthetic Pyrido[2,3‐c]Carbazole Alkaloid Derivative (PCAD) with Pu24T G‐quadruplex DNA

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Product

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N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp³)–H acylation

N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp³)–H acylation