Antimicrobial Activity of Mushroom Metabolites

Benedict, R. G.; Brady, L.R.

doi:10.1002/jps.2600611130

Cited by 58 publications

(40 citation statements)

References 24 publications

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“…Hence, they are rich sources of natural antibiotics. Many of the externalized secondary metabolites (extracellular secretions by the mycelium) are known to combat bacteria (Benedict & Brady, 1972;Kupra et al, 1979;Lindequist et al, 1990) and viruses (Eo et al, 1999). Several compounds extracted from mushroom revealed antifungal and antibacterial activity, namely against Staphylococcus aureus, Bacillus subtilis and Escherichia coli (Takazawa et al, 1982).…”

Section: Mushrooms As Antimicrobial Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

123

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Abstract:Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.

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Section: Mushrooms As Antimicrobial Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

123

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“…Both fruit- ing body and the mycelium contain compounds with wideranging antimicrobial activity. Mushrooms are rich sources of natural antibiotics; in these, the cell wall glucans are wellknown for their immunomodulatory properties, and many of the externalised secondary metabolites (extracellular secretions by the mycelium) combat bacteria [3,4] and viruses [5][6][7][8]. Additionally, the exudates from mushroom mycelia are active against protozoa such as the parasite that causes malaria, Plasmodium falciparum [9,10] and other microorganisms [11].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts

Barros

Calhelha

Vaz

et al. 2006

Eur Food Res Technol

223

141

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The antimicrobial properties of phenolic extracts of Portuguese wild edible mushroom species (Lactarius deliciosus, Sarcodon imbricatus and Tricholoma portentosum) against pathogens were investigated. The minimal inhibitory concentrations (MICs) were evaluated for the entire mushroom, the cap and the stipe, separately; the portion of the mushroom used proved to be influenced in the results obtained, which are directly correlated with the content of total phenols and flavonoids in the extracts. The growth of Grampositive bacteria (Bacillus cereus, B. subtilis,) was well inhibited by these mushrooms, while Escherichia coli (Gramnegative bacteria) was resistant. The study on the antifungal effect of these mushrooms revealed that Candida albicans and Cryptococcus neoformans were differently inhibited for the mushrooms used.

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“…The radical scavenging property of L. deliciosus has also been reported to be higher than the activity of most conventional antioxidants such as butylated hydroxytoluene and trolox [12]. Early research has shown that isolates from mushrooms have anticancer, cardiovascular, antiviral, antiparasitic, antibacterial, anti-inflammatory, blood lipid-lowering, immune response stimulating, and even antidiabetic effects [34][35][36]. Currently, extracts from several mushrooms including L. deliciosus have widespread application in Japan, Korea, and China, being used as potential adjuvants to radiation and chemotherapy [10,13].…”

Section: Pharmacological Potentials Of L Deliciosusmentioning

confidence: 99%

“…The two most recognized immune systems are the innate and the adaptive immune systems, both working in a specialized and functionalized pattern to ward off infection [34]. Evidence of a cross-link between the specialized cells of the two immune systems exists, such as the neutrophils which are innate cells but also involved in the workings of the adaptive immune system [35].…”

Section: The Interaction Between Nanomaterials and The Human Immune Smentioning

confidence: 99%

Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

Ukaegbu

Jalal²,

Rashid³

et al. 2017

Asian J Pharm Clin Res

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The pharmacological potential of bioactive compounds extracted from mushrooms has been studied to a reasonable level. In the same vein, the bioactivity of nanoparticles has also been investigated and reported to be of potential pharmacological benefit. No doubt, there is a reasonable amount of claims regarding the vast activity of the mushroom extracts and nanoparticles on the tested cell lines and microorganisms. In this paper, a review of the recent application of bioactive compounds extracted from two edible mushrooms (Coprinus comatus and Lactarius deliciosus), as well as some of the recently reported studies on some nanoparticles of pharmacological potentials, was carried out. In order to check for synergy in the bioactivity of the mushroom extracts when co-administered with nanoparticles, an investigation on the synergistic application of the materials through the encapsulation of the bioactive extracts from the mushroom onto the nanoparticle was proposed. The supposed synergy in the activity of the extract-nanoparticle complex could hold the key to improved activity of nutraceuticals against resistant microorganisms and tumor cells.

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Antimicrobial Activity of Mushroom Metabolites

Cited by 58 publications

References 24 publications

Mushrooms as therapeutic agents

Mushrooms as therapeutic agents

Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts

Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

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