Antimicrobial Activity of Monoramnholipids Produced by Bacterial Strains Isolated from the Ross Sea (Antarctica)

Tedesco, Pietro; Maida, Isabel; Esposito, Fortunato Palma; Tortorella, Emiliana; Subko, Karolina; Ezeofor, Chidinma C.; Zhang, Ying; Tabudravu, Jioji N.; Jaspars, Marcel; Fani, Renato; Pascale, Donatella de

doi:10.3390/md14050083

Cited by 48 publications

(43 citation statements)

References 46 publications

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“…Besides hemolytic activity, RL had been reported to possess antibacterial activity (Arutchelvi & Doble, ; Benincasa, Abalos, Oliveira, & Manresa, ; Haba et al, ; Tedesco et al, ). In an antimicrobial assay, the ADMT1 biosurfactant showed zone of inhibition against all the gram‐positive reference strains of bacteria from ATCC (Fig.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Biosurfactant Produced by a Novel Strain of Pseudomonas aeruginosa, Isolate ADMT1

Tiwary

Dubey

2018

J Surfact & Detergents

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Several biosurfactant-producing bacterial strains were isolated from petroleum-contaminated soil. The isolate ADMT1, identified as a new strain of Pseudomonas aeruginosa, was selected for further studies on the basis of oil displacement test and emulsification index (E24). The optimal parameters for production, determined by employing Box-Behnken design, were temperature 36.5 C and pH 7. The environmental isolate ADMT1 produced significant amount of biosurfactant (1.7 g L −1 in 72 h) in minimal salt medium (MSM) using dextrose as the sole carbon source. The E24 value and critical micelle concentration (CMC) of the biosurfactant was 100% and 150 mg L −1 , respectively. At CMC, the surface tension of water was reduced to 28.4 mN m −1 . The biosurfactant exhibited hemolytic activity and antibacterial activity against 8 reference strains of pathogenic bacteria, including 2 methicillin-resistant Staphylococcus aureus strains (MRSA ATCC 562 and MRSA ATCC 43300), with minimum inhibitory concentration (MIC) of 0.4 and 0.2 mg mL −1 , respectively. The structure of biosurfactant was characterized by FTIR, 1 H, and 13 C NMR spectroscopy. 7 di-rhamnolipid (RL) congeners were identified in the biosurfactant by ultraperformance liquid chromatographymass spectrometry analysis. The major congeners, which constituted 67% of the RL mixture, included Rha-Rha-C 10

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Section: Resultsmentioning

confidence: 99%

Characterization of Biosurfactant Produced by a Novel Strain of Pseudomonas aeruginosa, Isolate ADMT1

Tiwary

Dubey

2018

J Surfact & Detergents

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“…Compound 21 was effective against the tested human pathogens strains Burkholderia cepacia , B. metallica , B. seminalis , B. latens and Staphylococcus aureus with low MIC and minimun bacteriocidal concentration (MBC) values, while compound 22 only had moderate antimicrobial effect against S. aureus with an MBC value of 100 μg/mL [21]. …”

Section: Microorganismsmentioning

confidence: 99%

Secondary Metabolites from Polar Organisms

Tian

Zhao

2017

Marine Drugs

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Polar organisms have been found to develop unique defences against the extreme environment environment, leading to the biosynthesis of novel molecules with diverse bioactivities. This review covers the 219 novel natural products described since 2001, from the Arctic and the Antarctic microoganisms, lichen, moss and marine faunas. The structures of the new compounds and details of the source organism, along with any relevant biological activities are presented. Where reported, synthetic and biosynthetic studies on the polar metabolites have also been included.

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“…Screening for new anti‐ Burkholderia cepacia complex compounds from bacteria isolated from the Ross Sea (Antarctica) led to the isolation of three new rhamnolipids ( 91 – 93 ) from Pseudomonas strain BNT1 (Tedesco et al ).…”

Section: Permafrost Soilsmentioning

confidence: 99%

Extreme environments: microbiology leading to specialized metabolites

et al. 2019

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Summary The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the preantibiotic days of medicine at the time of diminishing numbers of drug leads. The good news is that an increased understanding of the nature and extent of microbial diversity in natural habitats coupled with the application of new technologies in microbiology and chemistry is opening up new strategies in the search for new specialized products with therapeutic properties. This review explores the premise that harsh environmental conditions in extreme biomes, notably in deserts, permafrost soils and deep‐sea sediments select for micro‐organisms, especially actinobacteria, cyanobacteria and fungi, with the potential to synthesize new druggable molecules. There is evidence over the past decade that micro‐organisms adapted to life in extreme habitats are a rich source of new specialized metabolites. Extreme habitats by their very nature tend to be fragile hence there is a need to conserve those known to be hot‐spots of novel gifted micro‐organisms needed to drive drug discovery campaigns and innovative biotechnology. This review also provides an overview of microbial‐derived molecules and their biological activities focusing on the period from 2010 until 2018, over this time 186 novel structures were isolated from 129 representatives of microbial taxa recovered from extreme habitats.

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Antimicrobial Activity of Monoramnholipids Produced by Bacterial Strains Isolated from the Ross Sea (Antarctica)

Cited by 48 publications

References 46 publications

Characterization of Biosurfactant Produced by a Novel Strain of Pseudomonas aeruginosa, Isolate ADMT1

Characterization of Biosurfactant Produced by a Novel Strain of Pseudomonas aeruginosa, Isolate ADMT1

Secondary Metabolites from Polar Organisms

Extreme environments: microbiology leading to specialized metabolites

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