Antimicrobial activity of Mimosa tenuiflora (Willd.) Poir. from Northeast Brazil against clinical isolates of Staphylococcus aureus

Abstract

RESUMO: "Atividade antimicrobiana de Mimosa tenuiflora (Willd.) Poir. do Nordeste do Brasil, contra isolados clínicos de Staphylococcus aureus". A Mimosa tenuiflora é uma planta nativa da região Nordeste do Brasil onde é conhecida como jurema-preta sendo amplamente utilizada na medicina popular. No presente trabalho a atividade anti-Staphylococcus aureus do extrato etanólico da M. tenuiflora foi avaliada pela determinação da concentração inibitória mínima (CIM), pelo método da diluição em agar, em 30 isolados clínicos e pela cinética de inativação com a linhagem referência. Os valores da CIM foram 0,18 mg/mL em 16 isolados e 0,36 mg/mL nos demais, bem como na linhagem referência. A cinética de inativação mostrou apenas efeito bacteriostático nas concentrações do extrato até aquela correspondente a 4x CIM e um rápido efeito bactericida na concentração correspondente a 8x CIM. Unitermos: Mimosa tenuiflora, extrato etanólico, atividade antimicrobiana, Staphylococcus aureus.ABSTRACT: Mimosa tenuiflora is a native plant of Northeast Brazil where it is popularly known as "jurema-preta" and it is widely used in folk medicine. In this work the anti-Staphylococcus aureus activity of ethanol extract of M tenuiflora was evaluated by determination of minimum inhibitory concentration (MIC) of clinical isolates by the agar dilution method, and by time-kill assay using a reference strain. MIC values against 30 isolates were 0,18 mg/mL (16/30) or 0,36 mg/ mL (14/30, and also the reference strain). In the reference strains, at concentrations up to 4x MIC, only bacteriostatic effect was observed, but at 8x MIC a fast bactericidal effect was observed.

A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

“…The results revealed that the extract successfully inhibited the growth of S. pyogenes , P. Mirabilis , S. sonnei , S. pyogenes, and Staphylococcus spp. Padilha et al [ 132 ] described the antibacterial activity of the EtOH extract of M. tenuiflora stem bark against S. aureus by using the minimum inhibitory concentration (MIC) with the agar dilution method and time-kill assay. At concentrations up to 4x MIC, only a bacteriostatic effect was observed, while at 8.x MIC a fast bactericidal effect was observed [ 133 ].…”

Mimosa tenuiflora Aqueous Extract: Role of Condensed Tannins in Anti-Aflatoxin B1 Activity in Aspergillus flavus

“…Its bark is widely used in traditional Mexican and Brazilian medicine as an effective remedy to treat skin burns and wounds [24,26]. This plant may be used to reduce venous ulceration [27]; accelerate the healing process [28]; act as an antimicrobial agent against Staphylococcus aureus [29], Micrococcus luteus, Bacillus subtilis, and Candida albicans [25]; and regenerate bone [30]. Several studies have isolated and identified the compounds present in different parts of M. tenuiflora.…”

Alternative Control of Phragmidium rubi-idaei Infecting Two Rubus Species

“…Citrus lemon ethanolic leaf extracts showed 61% inhibition rate for Alternaria sp. in a recent study [ 21 ]. In addition, chitosan nanoparticles coatings controlled successfully mycelial growth for Alternaria solani (72%) and Fusarium oxysporum (87%) in a study by Sathiyabama and Parthasarathy [ 29 ] therefore revealing the in vitro antifungal chitosan efficacy against these phytopathogenic fungi.…”

“…In addition, chitosan nanoparticles coatings controlled successfully mycelial growth for Alternaria solani (72%) and Fusarium oxysporum (87%) in a study by Sathiyabama and Parthasarathy [ 29 ] therefore revealing the in vitro antifungal chitosan efficacy against these phytopathogenic fungi. The Mimosa plant extract previously described, during in vitro testing, showed a strong antimicrobial activity against human pathogens [ 17 , 21 ]. Llorens et al [ 26 ] discovered a novel function of this plant extract: enhancing the immune response to Sclerotinia plant pathogen.…”

“…Among the most popular products with antifungal effects are the ones that hold in their composition Chitosan, a polymer extracted from the shells of marine Crustaceans, and which has already proven its efficiency in several laboratory trials [ 14 , 15 , 16 ]. Moreover, products that contain natural extracts from the bark of the Mimosa tree, cinnamon or citrus-based have recognized antimicrobial effects [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Zeolite, a volcanic tuff whose soil improvement capacities were made known in an extensive study led by Mumpton [ 25 ], has other positive agricultural effects subsequently attested, being involved in intensification of soil microbiology and the implicit increase of soil fertility [ 25 , 26 , 27 ].…”