Antimicrobial activity of kaempferol and resveratrol in binary combinations with parabens or propyl gallate against Enterococcus faecalis

Valle, Pilar del; García-Armesto, María Rosario; Arriaga, Dolores de; González-Donquiles, Carmen; Rodriguez-Fernandez, P.; Rúa, Javier

doi:10.1016/j.foodcont.2015.10.001

Cited by 51 publications

(35 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, it is possible that the presence of acids and therefore low pH inhibits microbial growth and degradation of complex sugars for energy, which would account for both the detection of complex sugars and wealth of acids. Secondly, these complex sugars could be playing a role in inhibiting microbial growth, which has been shown in previous literature for these seven sugar derivatives in other plants (Akroum et al, ; Chiruvella et al, ; Sati et al, ; Shi et al, ; Singh, Sharma, et al, ; del Valle et al, ). Finally, network analysis identified 211 known compounds and 21 unknown compounds that were first neighbors of these 17 antimicrobial compounds, suggesting there are potentially other compounds in the Sphagnum metabolome that contribute to antimicrobial effects.…”

Section: Discussionmentioning

confidence: 73%

“…First, it is possible that the presence of acids and therefore low pH inhibits microbial growth and degradation of complex sugars for energy, which would account for both the detection of complex sugars and wealth of acids. Secondly, these complex sugars could be playing a role in inhibiting microbial growth, which has been shown in previous literature for these seven sugar derivatives in other plants (Akroum et al, 2009;Chiruvella et al, 2007;Sati et al, 2019;Shi et al, 2016;Singh, Sharma, et al, 2011;del Valle et al, 2016). Finally, network analysis Peatland terrestrial ecosystems are the largest carbon sinks worldwide, driven largely by Sphagnum's dominance over other plant species, control of slow decay rates and water table fluctuations, and subsequent changes in redox chemistry of peat bogs (Tfaily et al, 2014).…”

Section: Discussionmentioning

confidence: 76%

“…To assess the antimicrobial similarities of chemical compounds between Sphagnum and medicinal plants, all m/z values from Sphagnum fallax were cross‐checked against a database of antimicrobial compounds confirmed in the FTICR‐MS analysis of the tested medicinal plants. The m/z of 17 known antimicrobial chemical compounds (Abedini et al, ; Akroum, Bendjeddou, Satta, & Lalaoui, ; Appendino et al, ; Bai et al, ; Chiruvella, Mohammed, Dampuri, Ghanta, & Raghavan, ; del Valle et al, ; Fiamegos et al, ; Huang, George, & Ebersole, ; Kandakumar & Manju, ; Lou et al, ; Mazimba, ; Nakatsuji et al, ; Narasimhan, Ohlan, Ohlan, Judge, & Narang, ; Sati, Dhyani, Bhatt, & Pandey, ; Shi et al, ; Singh, Sharma, Rani, Mishra, & Sharma, ) were confirmed to be present within Sphagnum . Two compounds had an associated isomer (Table ); therefore, while 17 compounds were associated with antimicrobial traits medicinal, only 15 m /z values were detected.…”

Section: Resultsmentioning

confidence: 99%

“…To assess the antimicrobial similarities of chemical compounds be- (Abedini et al, 2013;Akroum, Bendjeddou, Satta, & Lalaoui, 2009;Appendino et al, 2008;Bai et al, 2018;Chiruvella, Mohammed, Dampuri, Ghanta, & Raghavan, 2007;del Valle et al, 2016;Fiamegos et al, 2011;Huang, George, & Ebersole, 2010;Kandakumar & Manju, 2017;Lou et al, 2012;Mazimba, 2017;Nakatsuji et al, 2009;Narasimhan, Ohlan, Ohlan, Judge, & Narang, 2009;Sati, Dhyani, Bhatt, & Pandey, 2019;Shi et al, 2016;Singh, Sharma, Rani, Mishra, & Sharma, 2011) were confirmed to be present within Sphagnum.…”

Section: Seventeen Putative Antimicrobial Substances Detected By Ftmentioning

confidence: 99%

See 3 more Smart Citations

Untargeted metabolomic profiling ofSphagnum fallaxreveals novel antimicrobial metabolites

et al. 2019

View full text Add to dashboard Cite

Sphagnum mosses dominate peatlands by employing harsh ecosystem tactics to prevent vascular plant growth and microbial degradation of these large carbon stores. Knowledge about Sphagnum‐produced metabolites, their structure and their function, is important to better understand the mechanisms, underlying this carbon sequestration phenomenon in the face of climate variability. It is currently unclear which compounds are responsible for inhibition of organic matter decomposition and the mechanisms by which this inhibition occurs. Metabolite profiling of Sphagnum fallax was performed using two types of mass spectrometry (MS) systems and 1H nuclear magnetic resonance spectroscopy (1H NMR). Lipidome profiling was performed using LC‐MS/MS. A total of 655 metabolites, including one hundred fifty‐two lipids, were detected by NMR and LC‐MS/MS—329 of which were novel metabolites (31 unknown lipids). Sphagum fallax metabolite profile was composed mainly of acid‐like and flavonoid glycoside compounds, that could be acting as potent antimicrobial compounds, allowing Sphagnum to control its environment. Sphagnum fallax metabolite composition comparison against previously known antimicrobial plant metabolites confirmed this trend, with seventeen antimicrobial compounds discovered to be present in Sphagnum fallax, the majority of which were acids and glycosides. Biological activity of these compounds needs to be further tested to confirm antimicrobial qualities. Three fungal metabolites were identified providing insights into fungal colonization that may benefit Sphagnum. Characterizing the metabolite profile of Sphagnum fallax provided a baseline to understand the mechanisms in which Sphagnum fallax acts on its environment, its relation to carbon sequestration in peatlands, and provide key biomarkers to predict peatland C store changes (sequestration, emissions) as climate shifts.

show abstract

Section: Discussionmentioning

confidence: 73%

“…First, it is possible that the presence of acids and therefore low pH inhibits microbial growth and degradation of complex sugars for energy, which would account for both the detection of complex sugars and wealth of acids. Secondly, these complex sugars could be playing a role in inhibiting microbial growth, which has been shown in previous literature for these seven sugar derivatives in other plants (Akroum et al, 2009;Chiruvella et al, 2007;Sati et al, 2019;Shi et al, 2016;Singh, Sharma, et al, 2011;del Valle et al, 2016). Finally, network analysis Peatland terrestrial ecosystems are the largest carbon sinks worldwide, driven largely by Sphagnum's dominance over other plant species, control of slow decay rates and water table fluctuations, and subsequent changes in redox chemistry of peat bogs (Tfaily et al, 2014).…”

Section: Discussionmentioning

confidence: 76%

Section: Resultsmentioning

confidence: 99%

Section: Seventeen Putative Antimicrobial Substances Detected By Ftmentioning

confidence: 99%

See 2 more Smart Citations

Untargeted metabolomic profiling ofSphagnum fallaxreveals novel antimicrobial metabolites

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Despite numerous studies examining the antibacterial effects of combined natural compounds such as essential oils (Palaniappan & Holley, 2010;Patrone, Campana, Vittoria, & Baffone, 2010;Periago & Moezelaar, 2001;Rivera Calo, Crandall, O'Bryan, & Ricke, 2014) or phenols and organic acids (Del Valle et al, 2016;Vasconcelos de Oliveira, Montenegro Stamford, Gomes Neto, & Leite de Souza, 2010), information on the interaction of individual phenolic compounds with resveratrol are rather scarce (Chan, 2002;Del Valle et al, 2016). In this study, the antibacterial activity of selected phenolic compounds with resveratrol was tested by the microdilution method, and their interaction as binary phenolic mixtures was described by the fractional inhibitory concentration index (FICI) (Mundy, Pendry, & Rahman, 2016;Palaniappan & Holley, 2010;Petersen, Labthavikul, Jones, & Bradford, 2006).…”

Section: Antibacterial Activity Of Binary Phenolic Mixturesmentioning

confidence: 99%

Interactions of resveratrol with other phenolics and activity against food‐borne pathogens

Skroza

Šimat

Možina

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

The aim of this study was to investigate the antibacterial activity of individual phenolics and their binary mixtures with resveratrol against selected food‐borne pathogens. The antibacterial activity was quantified using the broth microdilution method by the determination of minimal inhibitory concentrations (MICs). Interactions between compounds in the binary phenolic mixtures were determined by calculating the fractional inhibitory concentration index (FICI). The influence of the number of OH groups in the phenols’ structure on their antibacterial activity was assessed by principal component analysis (PCA). The most effective compounds were flavone luteolin and flavonol rutin, while the weakest antimicrobial activity was observed for phenolic acid and flavan‐3‐ols (catechin and epicatechin). The synergistic effect (FICI ≤0.5) of equimolar mixture of resveratrol with kaempferol was confirmed against Staphylococcus aureus , Bacillus cereus , and Escherichia coli , while the mixture of rutin with resveratrol proved synergistic only against S. aureus . The increasing concentrations of resveratrol in the mixtures with kaempferol and rutin resulted in a loss of synergism which indicates that only selected phenolic mixtures, with optimal concentrations of their individual components, result in synergistic antibacterial activity. We did not find an association between total number of OH groups and antibacterial activity of either individual phenolics or their mixtures.

show abstract

Oral Administration of Kaempferol Isolated from Baccharis Mattogrosensis Enables In Vivo Activity Against Schistosoma Mansoni

Albuquerque,

Luz,

Rodrigues

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Baccharis mattogrosensis is a species from Asteraceae which has been used in Brazilian folk medicine to treatment of several illnesses, including those caused by parasites. In the present work, the MeOH extract of aerial parts of B. mattogrosensis was subjected to chromatographic fractionation to afford three flavonoids: apigenin (1), quercetin (2), and kaempferol (3) as well as a mixture three chlorogenic acids: 3,4‐O‐dicaffeoylquinic (4), 3,5‐O‐dicaffeoylquinic (5), and 4,5‐O‐dicaffeoylquinic (6) acids. When tested in vitro, kaempferol (3) exhibited activity against Schistosoma mansoni with EC50 = 81.86 μM, whereas compounds 1, 2, 4 – 6 showed to be inactives. Considering this result, the effects of kaempferol (3) against S. mansoni infection using in vivo assay was tested at first time. Using a single oral dose (400 mg/kg) of kaempferol (3) to S. mansoni‐infected mice reduced the worm burden by 25.5%. Similarly, the number of eggs, which are responsible for a variety of pathologies and transmission of schistosomiasis, was decreased by 28.8% in treated mice. Collectively, although kaempferol (3) is partially active when administered orally in a mouse model of schistosomiasis, our results suggest that this compound could be, in future studies, administered in different forms, such as nanoformulation.

show abstract

Antimicrobial activity of kaempferol and resveratrol in binary combinations with parabens or propyl gallate against Enterococcus faecalis

Cited by 51 publications

References 38 publications

Untargeted metabolomic profiling ofSphagnum fallaxreveals novel antimicrobial metabolites

Untargeted metabolomic profiling ofSphagnum fallaxreveals novel antimicrobial metabolites

Interactions of resveratrol with other phenolics and activity against food‐borne pathogens

Oral Administration of Kaempferol Isolated from Baccharis Mattogrosensis Enables In Vivo Activity Against Schistosoma Mansoni

Contact Info

Product

Resources

About