Antimicrobial activity of illudalane and alliacane sesquiterpenes from the mushroom Gloeostereum incarnatum BCC41461

Bunbamrung, Nantiya; Intaraudom, Chakapong; Dramae, Aibrohim; Boonyuen, Nattawut; Veeranondha, Sukitaya; Rachtawee, Pranee; Pittayakhajonwut, Pattama

doi:10.1016/j.phytol.2017.05.017

Cited by 27 publications

(14 citation statements)

References 20 publications

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“…In our previous study, GI was confirmed to show immunomodulatory function in a cyclophosphamide monohydrate-induced mouse model by increasing immune-related factors including immunoglobulin (Ig) ( 7 ). Due to its anti-microbial activities, GI shows beneficial effects on gastrointestinal diseases including gastric ulcer and enteritis ( 18 ). However, thus far, there has been no systematic research on the protective effect of GI against UC.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Gloeostereum�incarnatum on ulcerative colitis via modulation of Nrf2/NF‑κB signaling in C57BL/6 mice

Liu

Zhang

et al. 2020

Mol Med Rep

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Chronic non-specific inflammatory cell infiltration of the colon is generally considered to be the cause of ulcerative colitis (UC). Gloeostereum incarnatum (GI), a fungus rich in amino acids and fatty acids, exhibits a variety of biological functions. In the present study, GI was identified to contain 15 fatty acids, 17 amino acids and 11 metallic elements. The protective effect of GI against UC was investigated in C57BL/6 mice with UC induced by free drinking 3.5% dextran sulfate sodium (DSS). After a 21-day oral administration, GI prevented weight loss, enhancement of the disease activity index and colonic pathological alterations in mice with UC. GI reduced the levels of pro-inflammatory factors including interleukin (IL)-1β, IL-2, IL-6 and IL-12, tumor necrosis factor α and -β, interferon α and -γ, and pro-oxidative factors including reactive oxygen species and nitric oxide. In addition, it enhanced the levels of immunological factors including immunoglobulin (Ig)A, IgM and IgG, and antioxidative factors including superoxide dismutase and catalase in the serum and/or colon tissues. GI enhanced the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins and suppressed the phosphorylation of NF-κB signaling in colon tissues. Together, GI was shown to alleviate the physiological and pathological state of DSS-induced UC in mice via its antioxidant and anti-inflammatory functions, which may be associated with its modulation of the activation of Nrf2/NF-κB signaling.

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Section: Introductionmentioning

confidence: 99%

Protective effect of Gloeostereum�incarnatum on ulcerative colitis via modulation of Nrf2/NF‑κB signaling in C57BL/6 mice

Liu

Zhang

et al. 2020

Mol Med Rep

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“…Gloeostereum incarnatum, a precious edible mushroom, parasitizes broad-leaved wood in northern Japan and northern China (17). Traditionally, G. incarnatum preparation is widely used for the treatment for enteritis, dysentery and gastric ulcer (18). Polysaccharides obtained from G. incarnatum fruiting body have been reported to possess anti-tumor and anti-bacterial activities (17).…”

Section: Introductionmentioning

confidence: 99%

The investigation of immunomodulatory activities of Gloeostereumï¿½incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice

Wang

et al. 2018

Exp Ther Med

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Abstract. Gloeostereum incarnatum, a precious edible mushroom, displays anti-bacterial and anti-inflammatory activities; however, its immunomodulatory effect has not been studied yet. The present study aimed to investigate whether polysaccharide compositions of G. incarnatum polysaccharides (GIPS) possess immunomodulatory and immuno-enhancing effects in a Cyclophosphamide monohydrate (CTX)-induced BALB/c mice model. The 28-day GIPS administration at doses of 0.1, 0.3 and 0.9 g/kg remarkably reversed the bodyweight loss, increased the thymic index and promoted T lymphocyte proliferation in CTX-induced immunosuppressed mice. GIPS significantly raised the serum levels of immunoglobulin (Ig) A and IgG, promoted the production of interleukins (ILs), including IL-2, IL-3 and IL-6, interferons, including interferon (IFN)-α and IFN-γ, and monocyte chemotactic protein 1 in the spleen, which resulted in accelerating recovery of immunosuppression. Finally, GIPS showed anti-oxidative effects indicated by the increased superoxide dismutase levels in the serum and spleen, and the reduced level of reactive oxygen species in the spleen. The results of the current study demonstrated that GIPS positively adjusts the immune system, which may serve as a potential immunostimulatory agent. IntroductionThe immune system, a complex self-regulation system, is responsible for the defense function of organism to prevent outside pathogens, remove the waste material and maintain the monitoring function for malignant cells (1). The immune system is highly sensitive (2), and shows impaired immune responsiveness to pathogen invasion, during which, immune cells are activated and secret pro-inflammatory mediators including interleukins (ILs) and interferons (INFs) are increased (3,4). And immunity closely related to oxidative stress, which could lead to aberrant expression of inflammatory cytokines and chemokines (5). Cyclophosphamide monohydrate (CTX), a cancer chemotherapeutic agent, facilitates cell apoptosis and decreases the homeostatic proliferation of regulatory T cells (6), which has been widely used in the establishment of immunosuppressive animal models (7-9).Previous researchers focus their studies on searching immunomodulatory agents for years (10). However, the drugs performed in clinic, especially single-component chemicals, display severe adverse effects including general malaise and/or neurotoxicity (11,12), which is hard to meet the requirements of immunosuppressive patients. Dietary polysaccharides from natural products are getting more attention due to their health benefits and low toxicity (13,14), which have been confirmed to exhibit multiple immunomodulatory effects (15,16). Gloeostereum incarnatum, a precious edible mushroom, parasitizes broad-leaved wood in northern Japan and northern China (17). Traditionally, G. incarnatum preparation is widely used for the treatment for enteritis, dysentery and gastric ulcer (18). Polysaccharides obtained from G. incarnatum fruiting body have been reported to possess anti-tumor and ant...

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“…In contrast, G. incarnatum is an edible mushroom with medicinal activity and has been confirmed to produce antimicrobial compounds [ 43 ]. The compounds incarnatins A−E, incarnolactones A−C, incarnate methyl ester, incarnetic acid, and incarnatenin showed antimalarial, antituberculosis, and anti- Bacillus activity [ 44 ]. The species is geographically confined to China, Japan, Siberia, and Taiwan [ 20 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Gloeostereum cimri , a novel shelf fungus isolated from a human pulmonary cyst

Ahmed

Hoog

Kim

et al. 2020

Emerging Microbes & Infections

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Filamentous basidiomycetes are uncommon agents of human diseases, despite their ubiquitous presence in the environment. We present a case of symptomatic pulmonary infection in a 38-year-old male with cough and fever; a thin-walled cyst in the posterior left upper pulmonary lobe was revealed by radiography. A non-sporulating fungus was isolated from sputum and biopsy material from the cyst. ITS and LSU sequences placed the fungus phylogenetically in Agaricales , family Cyphellaceae , and identified it as a member of shelf fungi in Gloeostereum, but without identity to any known species. The new species is described as Gloeostereum cimri . The clinical strain showed high MIC to voriconazole (>8 µg/ml) but had low MIC to amphotericin B (0.5 µg/ml).

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Antimicrobial activity of illudalane and alliacane sesquiterpenes from the mushroom Gloeostereum incarnatum BCC41461

Cited by 27 publications

References 20 publications

Protective effect of Gloeostereum�incarnatum on ulcerative colitis via modulation of Nrf2/NF‑κB signaling in C57BL/6 mice

Protective effect of Gloeostereum�incarnatum on ulcerative colitis via modulation of Nrf2/NF‑κB signaling in C57BL/6 mice

The investigation of immunomodulatory activities of Gloeostereumï¿½incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice

Gloeostereum cimri , a novel shelf fungus isolated from a human pulmonary cyst

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