Antimicrobial activity of
            <i>Buchenavia tetraphylla</i>
            against
            <i>Candida albicans</i>
            strains isolated from vaginal secretions

Filho, José Robson Neves Cavalcanti; Silva, Tiago Fonseca; Nobre, Woah Queiroz; Souza, Larissa Isabela Oliveira de; Figueiredo, Cristiane Santos Silva e Silva; Figueiredo, Regina Célia Bressan Queiroz de; Gusmão, Norma Buarque de; Silva, Márcia Vanusa; Silva, Luís Cláudio Nascimento da; Correia, Maria Tereza dos Santos

doi:10.1080/13880209.2017.1304427

Cited by 14 publications

(9 citation statements)

References 38 publications

(43 reference statements)

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“… Cavalcanti Filho et al (2017) verified that the methanolic extract of Buchenavia tetraphylla is a great source of antimicrobial compounds that enhance the action of FLZ against different C. albicans isolates from vaginal secretions as well as azole-resistant isolates. The extract increased the action of FLZ in most strains through additive (20% of strains) or synergistic (60% of strains) effects.…”

Section: Peptides As Antifungal Agentsmentioning

confidence: 77%

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

et al. 2018

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The Candida genus comprises opportunistic fungi that can become pathogenic when the immune system of the host fails. Candida albicans is the most important and prevalent species. Polyenes, fluoropyrimidines, echinocandins, and azoles are used as commercial antifungal agents to treat candidiasis. However, the presence of intrinsic and developed resistance against azole antifungals has been extensively documented among several Candida species. The advent of original and re-emergence of classical fungal diseases have occurred as a consequence of the development of the antifungal resistance phenomenon. In this way, the development of new satisfactory therapy for fungal diseases persists as a major challenge of present-day medicine. The design of original drugs from traditional medicines provides new promises in the modern clinic. The urgent need includes the development of alternative drugs that are more efficient and tolerant than those traditional already in use. The identification of new substances with potential antifungal effect at low concentrations or in combination is also a possibility. The present review briefly examines the infections caused by Candida species and focuses on the mechanisms of action associated with the traditional agents used to treat those infections, as well as the current understanding of the molecular basis of resistance development in these fungal species. In addition, this review describes some of the promising alternative molecules and/or substances that could be used as anticandidal agents, their mechanisms of action, and their use in combination with traditional drugs.

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Section: Peptides As Antifungal Agentsmentioning

confidence: 77%

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

et al. 2018

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“…Herein, we report the selection of high antioxidant fractions from B. tetraphylla leaf extracts using in vitro and in vivo approaches. Products derived from this plant have been shown as potential candidates for the development of new antimicrobial agents [20][21][22]; however, their antioxidant actions have not been properly addressed. The in vitro results obtained in this study showed that the methanolic extract (BTME) had a higher antioxidant activity, and this effect was correlated with its higher phenolic and flavonoid content.…”

Section: Discussionmentioning

confidence: 99%

“…B. tetraphylla is popularly known as "tanimbuca" in Brazil, where it has ethnomedicinal importance for communities in the northeast region [19]. It is also known to have a broad spectrum of antimicrobial activity, inhibiting bacteria, fungi, and virus [20][21][22]. Buchenavianine and two derivatives (O-demethylbuchenavianine, N,O-bis-(demethyl)buchenavianine) have been isolated from B. tetraphylla.…”

Section: Introductionmentioning

confidence: 99%

Products Derived from Buchenavia tetraphylla Leaves Have In Vitro Antioxidant Activity and Protect Tenebrio molitor Larvae against Escherichia coli-Induced Injury

et al. 2020

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The relevance of oxidative stress in the pathogenesis of several diseases (including inflammatory disorders) has traditionally led to the search for new sources of antioxidant compounds. In this work, we report the selection of fractions with high antioxidant action from B. tetraphylla (BT) leaf extracts. In vitro methods (DPPH and ABTS assays; determination of phenolic and flavonoid contents) were used to select products derived from B. tetraphylla with high antioxidant action. Then, the samples with the highest potentials were evaluated in a model of injury based on the inoculation of a lethal dose of heat-inactivated Escherichia coli in Tenebrio molitor larvae. Due to its higher antioxidant properties, the methanolic extract (BTME) was chosen to be fractionated using Sephadex LH-20 column-based chromatography. Two fractions from BTME (BTFC and BTFD) were the most active fractions. Pre-treatment with these fractions protected larvae of T. molitor from the stress induced by inoculation of heat-inactivated E. coli. Similarly, BTFC and BTFD increased the lifespan of larvae infected with a lethal dose of enteroaggregative E. coli 042. NMR data indicated the presence of aliphatic compounds (terpenes, fatty acids, carbohydrates) and aromatic compounds (phenolic compounds). These findings suggested that products derived from B. tetraphylla leaves are promising candidates for the development of antioxidant and anti-infective agents able to treat oxidative-related dysfunctions.

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“…The lowest concentration, at which no color change occurred, was taken as the MIC. Afterward, cultures were seeded in SDA plates, incubated for 48 h at 30 º C, and consequently minimum fungicidal concentration (MFC) was determined [20].…”

Section: Methodsmentioning

confidence: 99%

Antifungal effect of the effect of Securigera securidaca L. vaginal gel on Candida species

Vanani¹,

Mahdavinia²,

Kalantari‬³

et al. 2019

CMM

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Background and Purpose: Candida species are opportunistic fungi, capable of causing acute and chronic infections in the gastrointestinal tract, vagina, and oral mucosa, among which Candida albicans is the most important species. The Securigera securidaca L. is used as an antiseptic to treat some diseases in traditional Iranian medicine. The aim of this study was to evaluate the antimicrobial activity of S. securidaca extracts and vaginal gel against different Candida species.Materials and Methods:Antifungal effects of different extracts and vaginal gel of S. securidaca were investigated against Candida species. By using well diffusion test, different concentrations of the collected S. securidaca extracts and vaginal gel were examined to test their antifungal activity against C. albicans, C. parapsilosis, and C. krusei.Results:The ethanol extract and vaginal gel with the ethanol extract of S. securidaca showed the most anti-fungal activity against all three strains.Conclusion:The S. securidaca extract had a significant inhibitory effect on the different species of Candida; however, the highest inhibitory effect was found against C. albicans. In order to treat candidiasis, more research is required to check the efficacy of this plant in this domain.

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Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions

Abstract: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division.

Cited by 14 publications

References 38 publications

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

Products Derived from Buchenavia tetraphylla Leaves Have In Vitro Antioxidant Activity and Protect Tenebrio molitor Larvae against Escherichia coli-Induced Injury

Antifungal effect of the effect of Securigera securidaca L. vaginal gel on Candida species

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