Antimicrobial activity of Annona muricata leaf oleoresin

Abstract

Bioactive compounds extracted from plants such as antimicrobials have attracted the attention of consumers and the food industry. This study aimed to determine the antimicrobial activity and chemical composition of Annona muricata leaf oleoresin obtained by supercritical CO2 extraction. The oleoresin was obtained by supercritical CO2 extraction and the chemical identification by gas chromatography coupled to mass spectrometry. Antimicrobial activity was evaluated by broth microdilution method against 14 foodborne fungi and bacteria. The oleoresin major chemical class was phytosterols (22.7%) and the major compounds were γ-sitosterol (15.7%), α-tocopherol (13.7%), phytol (13.1%), and hexadecanoic acid (11.5%). Minimum inhibitory concentration against bacteria ranged from 0.0025 to 0.010 mg mL −1 . The oleoresin had high bactericidal activity against all bacteria, mainly Enterobacter cloacae and Pseudomonas aeruginosa with 0.005 mg mL −1 minimum bactericidal concentration. However, it had low fungicidal activity. The leaf oleoresin of A. muricata has promising applications in food, cosmetic, and pharmaceutical industries.

Acetogenins from Annona muricata as Antimicrobial Agents

“…muricata has a significant content of bioactive compounds such as phenolic compounds, glucosinolates, steroids, saponins, glycosides, terpenoids, polyesterols, alkaloids, and mainly ACGs with unique chemical structures. These bioactive compounds have been extracted from the leaves [4,[16][17][18][19][20][21][22], stem [21], root [21], pulp [23,24], seed [11,21,[25][26][27], and peel [21]. ACGs are molecules distinguished by a long aliphatic chain of 35 to 37 carbon atoms attached to one, two, or three tetrahydrofuran or tetrahydropyran rings in its central region.…”

Soursop (Annona muricata) Properties and Perspectives for Integral Valorization

“…In addition to the essential oil, it is possible to obtain oleoresin; however, it differs in physical and chemical terms in liquid form under environmental conditions, while oleoresin may contain waxes in solid or semi-solid form [ 74 ]. Soursop leaf oleoresin has bactericidal activity containing 22.7% of phytosterols as the main class of compounds [ 75 ].…”

Kandungan Senyawa Oleoserin Baeckea. frutescens L Pada Beberapa Pelarut

“…Telah banyak peneliti melaporkan manfaat oleoresin pada bidang pangan, farmasi dan kosmetik (Widiyanto & Anandito, 2013;Athaillah & Lianda, 2021;Cagnini et al, 2021;Madankar & Nair, 2021). Marga .…”