Antimicrobial Activity of Extracts from Native Plants of Temperate Australia

Wigmore, Sarah M.; Naiker, Mani; Bean, David C.

doi:10.5530/pc.2016.2.5

Cited by 23 publications

(23 citation statements)

References 26 publications

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“…A further 17 % of relevant literature used a water-based extraction protocol, with only three studies using relatively non-polar solvents (diaminopropane, chloroform and acetone). This is consistent with a wide body of research indicating that relatively polar extracted fractions generally contain a greater level of bioactive and antimicrobial compounds compared to their nonpolar counterparts (Han et al, 2007;Tian et al, 2009;Wigmore et al, 2016). This may also be indicative of increased bioactivity of highly polar glycosylated compounds, similar to the vast difference in antiviral activity observed between quercetin and quercetin-7-rhamnoside (Choi et al, 2009).…”

Section: The Significance Of Chemical Polaritysupporting

confidence: 87%

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

et al. 2020

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Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents for many coronavirus strains. Naturally existing compounds provide a wealth of chemical diversity, including antiviral activity, and thus may have utility as therapeutic agents against coronaviral infections. The PubMed database was searched for papers including the keywords coronavirus, SARS or MERS, as well as traditional medicine, herbal, remedy or plants, with 55 primary research articles identified. The overwhelming majority of publications focussed on polar compounds. Compounds that show promise for the inhibition of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, saikosaponin B 2 , quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins such as griffithsin. Other compounds such as lycorine may be suitable if a therapeutic level of antiviral activity can be achieved without exceeding toxic plasma concentrations. It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.

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Section: The Significance Of Chemical Polaritysupporting

confidence: 87%

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

et al. 2020

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“…Recently, antimicrobial activities of methanol extract of M. alternifolia were screened against both Gram‐positive and Gram‐negative species: B. subtilis , L. monocytogenes , M. luteus , S. aureus , E. coli , K. pneumoniae , P. aeruginosa , and S. enterica by broth dilution method. The plant extracts was very active against Gram‐positive bacteria, particularly M. luteus (MIC 0.06 mg/mL) (Wigmore et al ., ). Pseudomonas spp.…”

Section: Melaleuca Spp Plants As Antibacterial and Antifungal Agentsmentioning

confidence: 97%

“…Concentrations of 0. dilution method. The plant extracts was very active against Gram-positive bacteria, particularly M. luteus (MIC 0.06 mg/mL) (Wigmore et al, 2016). Pseudomonas spp.…”

Section: Melaleuca Alternifoliamentioning

confidence: 99%

Plants of theMelaleucaGenus as Antimicrobial Agents: From Farm to Pharmacy

Sharifi‐Rad

Salehi

Varoni

et al. 2017

Phytotherapy Research

130

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Plants belonging to Melaleuca genus (Myrtaceae family) are native to Oceania, where they have been used for ages by Aborigine people in Australian traditional medicine, mainly because of their broad-spectrum antimicrobial activity. Although, M. linariifolia, M. dissitiflora, and other species of Melaleuca can also be used, the tea tree oil, an essential oil obtained from M. alternifolia shows the longest history of medicinal uses. Tea tree oil contains for the 80-90% several monoterpenes (terpinen-4-ol, α-terpinene, 1,8-cineol, p-cymene, α-terpineol, α-pinene, terpinolene, limonene, and sabinene). Sesquiterpenes and aromatic compounds further compose this oil. The essential oil of Melaleuca spp. has been reported to possess effective antibacterial and antifungal properties in vitro. In particular, data show that 1,8-cineol, terpinen-4-ol and methyl eugenol play the key role in mediating this oil's antimicrobial activity. Copyright © 2017 John Wiley & Sons, Ltd.

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“…One study reported that a W. fruticosa leaf extract was a potent inhibitor of L. monocytogenes, M. luteus and S. aureus growth in a disc diffusion assay. 26 The same extract was inactive or had only low activity against B. subtilis, E. coli, K, pneumonia P. aeruginosa and S. typhimurium. This contrasts with the results of our current study, which determined that W. fruticosa leaf and flower extracts were completely ineffective against an extended panel of bacteria.…”

Section: Discussionmentioning

confidence: 99%

“…However, a recent study reported potent growth inhibitory activity for W. fruticosa leaf extracts against Listeria monocytogenes, Micrococcus luteus and Staphylococcus aureus. 26 The same study reported lower activity or no activity at all against against Bacillus subtilis, Escherichia coli, Klebsiellia pneumonia Pseudomonas aeruginosa and Salmonella typhimurium. In contrast, a different study reported that W. fruticosa leaf and flower extracts were completely ineffective against Aeromonas hydrophilia, Pseudomonas fluorescens, Bacillus cereus and Bacillus subtilis.…”

Section: Introductionmentioning

confidence: 92%

Westringa fruticosa (Willd.) Druce Leaf and Flower Extracts Lack Antibacterial Activity and are Non-toxic in vitro

Chikowe¹,

Mpala²,

Cock³

2019

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Introduction: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a family are known to possess therapeutic properties. The family Laminaceae has a long history of medicinal usage globally. Many species are known to have therapeutic properties, several species of which have well established antibacterial bioactivities. Methods: The ability of Westringa fruticosa leaf and flower extracts to inhibit the growth of a panel of bacterial and fungal pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: W. fruticosa leaf methanolic and aqueous extracts were both completely ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria, as well as fungi. The extracts were non-toxic or of low toxicity in the Artemia bioassay following 24 h exposure. Conclusion: Despite the taxonomic relationship to several bioactive Laminaceae spp., W. fruticosa leaf and flower extracts were completely ineffective bacterial and fungal growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, virus and tumour cells is required.

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Antimicrobial Activity of Extracts from Native Plants of Temperate Australia

Cited by 23 publications

References 26 publications

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

Plants of theMelaleucaGenus as Antimicrobial Agents: From Farm to Pharmacy

Westringa fruticosa (Willd.) Druce Leaf and Flower Extracts Lack Antibacterial Activity and are Non-toxic in vitro

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