Antimicrobial Activity of Electrospun Polyvinyl Alcohol Nanofibers Filled with Poly[2-(tert-butylaminoethyl) Methacrylate]-Grafted Graphene Oxide Nanosheets

Huang, Chien‐Lin; Lee, Kun‐Mu; Liu, Zheng-Xian; Lai, Ruo-Yu; Chen, Chih‐Kuang; Chen, Wen‐Cheng; Hsu, Jen‐Fu

doi:10.3390/polym12071449

Cited by 20 publications

(14 citation statements)

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“…Irrespective of the PG loading shown in ( Table 1 ), in some instances, the pores penetrate deep into the fibre [ 47 ]. The surface pores are therefore beneficial in exposing the PG layers to the environment, which is useful in antimicrobial applications [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Porous Graphene Composite Polymer Fibres

et al. 2020

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Since the isolation of graphene, there have been boundless pursuits to exploit the many superior properties that this material possesses; nearing the two-decade mark, progress has been made, but more is yet to be done for it to be truly exploited at a commercial scale. Porous graphene (PG) has recently been explored as a promising membrane material for polymer composite fibres. However, controlling the incorporation of high surface area PG into polymer fibres remain largely unexplored. Additionally, most polymer-graphene composites suffer from low production rates and yields. In this paper, graphene-loaded microfibres, which can be produced at a very high rate and yield have been formed with a carrier polymer, polycaprolactone. For the first time, PG has been incorporated into polymer matrices produced by a high-output manufacturing process and analysed via multiple techniques; scanning electron microscopy (SEM), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Raman spectra showed that single layer graphene structures were achieved, evidence for which was also backed up by the other techniques. Fibres with an average diameter ranging from 3–8 μm were produced with 3–5 wt% PG. Here, we show how PG can be easily processed into polymeric fibres, allowing for widespread use in electrical and ultrafiltration systems

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Section: Resultsmentioning

confidence: 99%

Porous Graphene Composite Polymer Fibres

et al. 2020

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“…In addition to PDMAEMA, another antimicrobial polymer, poly(2- tert -butylaminoethyl methacrylate) (PTBAEMA) that is hydrophobic was contained in various blends or capsules [ 32 , 33 , 34 ]. It displaced Ca 2+ and/or Mg 2+ ions from the outer bacterial membrane, which became disorganized and disrupted [ 33 , 35 ]. Obviously, large pendant tert -butylamino groups of PTBAEMA were not necessarily quaternized to become antibacterial.…”

Section: Introductionmentioning

confidence: 99%

Cationic Polymer-Coated Magnetic Nanoparticles with Antibacterial Properties: Synthesis and In Vitro Characterization

et al. 2021

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Uniformly sized magnetite nanoparticles (Dn = 16 nm) were prepared by a thermal decomposition of Fe(III) oleate in octadec-1-ene and stabilized by oleic acid. The particles were coated with Sipomer PAM-200 containing both phosphate and methacrylic groups available for the attachment to the iron oxide and at the same time enabling (co)polymerization of 2-(dimethylamino)ethyl methacrylate and/or 2-tert-butylaminoethyl methacrylate at two molar ratios. The poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and poly[2-(dimethylamino)ethyl methacrylate-co-2-tert-butylaminoethyl methacrylate] [P(DMAEMA-TBAEMA)] polymers and the particles were characterized by 1H NMR spectroscopy, size-exclusion chromatography, transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, magnetometry, and ATR FTIR and atomic absorption spectroscopy. The antimicrobial effect of cationic polymer-coated magnetite nanoparticles tested on both Escherichia coli and Staphylococcus aureus bacteria was found to be time- and dose-responsive. The P(DMAEMA-TBAEMA)-coated magnetite particles possessed superior biocidal properties compared to those of P(DMAEMA)-coated one.

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“…No difference was observed between the PCL and PCL- g -PAA composite mats. The morphology of GO- g -PTA in the PCL-based electrospun nanofibers was consistent with that of PVA/GO- g -PTA composite mats [ 44 ].…”

Section: Resultsmentioning

confidence: 55%

“…GO and GO- g -PTA were synthesized with Hummers’ method. The specific process (ATRP) was mentioned in our previous study [ 44 ]. For samples containing GO- g -PTA, GO- g -PTA was mixed with chloroform and DMF in an ultrasonic mixer for 3 h, and then PCL and AA were added.…”

Section: Methodsmentioning

confidence: 99%

“…To improve the antibacterial ability of GO, cationic polymers, such as polyethyleneimine and poly[2-(tert-butylaminoethyl) methacrylate] (PTA), can be used to modify GO [ 43 ]. Huang et al [ 44 ] showed that PTA grafted onto the surface of GO through free radical polymerization and atom transfer radical polymerization (ATRP) improve the antibacterial efficiency of GO. A composite nanofiber mat consisting of electrospun nanofibers and GO- g -PTA nanosheets prepared through ATRP showed good antibacterial ability and non-cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

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Microstructure and Biological Properties of Electrospun In Situ Polymerization of Polycaprolactone-Graft-Polyacrylic Acid Nanofibers and Its Composite Nanofiber Dressings

Huang

Lai

et al. 2021

Polymers

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In this study, polycaprolactone (PCL)- and poly(acrylic acid) (PAA)-based electrospun nanofibers were prepared for the carriers of antimicrobials and designed composite nanofiber mats for chronic wound care. The PCL- and PAA-based electrospun nanofibers were prepared through in situ polymerization starting from PCL and acrylic acid (AA). Different amounts of AA were introduced to improve the hydrophilicity of the PCL electrospun nanofibers. A compatibilizer and a photoinitiator were then added to the electrospinning solution to form a grafted structure composed of PCL and PAA (PCL-g-PAA). The grafted PAA was mainly located on the surface of a PCL nanofiber. The optimization of the composition of PCL, AA, compatibilizer, and photoinitiator was studied, and the PCL-g-PAA electrospun nanofibers were characterized through scanning electron microscopy and 1H-NMR spectroscopy. Results showed that the addition of AA to PCL improved the hydrophilicity of the electrospun PCL nanofibers, and a PCL/AA ratio of 80/20 presented the best composition and had smooth nanofiber morphology. Moreover, poly[2 -(tert-butylaminoethyl) methacrylate]-grafted graphene oxide nanosheets (GO-g-PTA) functioned as an antimicrobial agent and was used as filler for PCL-g-PAA nanofibers in the preparation of composite nanofiber mats, which exerted synergistic effects promoted by the antibacterial properties of GO-g-PTA and the hydrophilicity of PCL-g-PAA electrospun nanofibers. Thus, the composite nanofiber mats had antibacterial properties and absorbed body fluids in the wound healing process, thereby promoting cell proliferation. The biodegradation of the PCL-g-PAA electrospun nanofibers also demonstrated an encouraging result of three-fold weight reduction compared to the neat PCL nanofiber. Our findings may serve as guidelines for the fabrication of electrospun nanofiber composites that can be used mats for chronic wound care.

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Antimicrobial Activity of Electrospun Polyvinyl Alcohol Nanofibers Filled with Poly[2-(tert-butylaminoethyl) Methacrylate]-Grafted Graphene Oxide Nanosheets

Cited by 20 publications

References 57 publications

Porous Graphene Composite Polymer Fibres

Porous Graphene Composite Polymer Fibres

Cationic Polymer-Coated Magnetic Nanoparticles with Antibacterial Properties: Synthesis and In Vitro Characterization

Microstructure and Biological Properties of Electrospun In Situ Polymerization of Polycaprolactone-Graft-Polyacrylic Acid Nanofibers and Its Composite Nanofiber Dressings

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