Antimicrobial Activity of Chlorhexidine Gluconate Against Natural and Artificial Contamination During Simulation of in-use Conditions

Aly, Raza

doi:10.1002/jps.2600700839

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…[4] Chlorhexidine is an effective antimicrobial agent and shows action against a wide range of organisms. [19] Its mechanism of action relates to its inhibitory effect on the pellicle formation, alteration of bacterial adherence to teeth and due to its positive charge, it interacts with the negatively charged cell walls of the bacteriae and enters the cell, causing the lysis of the microbe. Chlorhexidine in a sustained release formulation, has been shown to be effective against subgingival plaque bacteria when used for 7-10 days.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Local Drug Delivery of Chlorhexidine and Ornidazole in the Treatment of Gingivitis as an Adjunct to Scaling and Root Planing

Narayanan¹,

Prabhuji²,

Bhavikatti³

et al. 2020

IJFMT

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Background: Local drug delivery to gingival sulcus avoids adverse effects seen with systemic therapy and there is very little information to substantiate the additive effect of the drugs, the current study makes an attempt in same regard. Aim:The objective of this study was to compare the local application of ornidazole and chlorhexidine gel (Clorni TM gel) as an adjunct to scaling and polishing, with scaling and polishing alone.Materials and methods: 33 patients meeting inclusion criteria were randomly allocated to treatment groups by computerized randomly selection method. Indices were recorded at baseline at their first visit. Supragingival and subgingival scaling and polishing was performed using hand and ultrasonic instruments. The patients were evaluated clinically by using the gingival index, plaque index and modified sulcus bleeding index. On test side, Clorni TM gel was applied subgingivally after nonsurgical periodontal therapy. On the control side, no intervention was done following subgingival scaling and polishing. Patients were recalled at 7 th day for subsequent administration of gel on the same site and followed up at 21 st day and 3 months to compare the gingival condition by using the indices.Results: All subjects showed significant improvement over 3 months recall period, irrespective of test or controls. Statistical significance (p˂ 0.05) was observed at 7 days and 21 days for test group for the gingival index and at 21 days for the plaque index and modified sulcus bleeding index. Conclusion:The topical gel when used as an adjunct to scaling and polishing had significant results.

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Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Local Drug Delivery of Chlorhexidine and Ornidazole in the Treatment of Gingivitis as an Adjunct to Scaling and Root Planing

Narayanan¹,

Prabhuji²,

Bhavikatti³

et al. 2020

IJFMT

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“…In 2010, a 2% CHX gluconate aqueous solution came on the market as Vet One (MWI Animal Health, Boise, ID), labeled for use on intact or damaged skin of horses and dogs. Regarding storage of CHX, open containers of 4% CHX gluconate exposed to artificial and natural bacterial contamination over a course of 6 months have proven to resist bacterial growth ( 21 ), however dilute preparations (<2%) are susceptible to bacterial contamination and should not be pre-mixed and stored ( 11 , 22 ).…”

Section: Chlorhexidinementioning

confidence: 99%

Small animal patient preoperative preparation: a review of common antiseptics, comparison studies, and resistance

Nye,

Thieman Mankin

2024

Front. Vet. Sci.

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This review aims to describe commonly used antiseptics in veterinary medicine including their mechanism of action, spectrum of activity, potential adverse effects, and application techniques. Additionally, it provides a review of the veterinary literature comparing antiseptics, a discussion of effectiveness and efficacy studies, and the potential for increased resistance to biocides and antimicrobials. This review concludes that appropriate selection and use is necessary to prevent the occurrence of surgical site infections, adverse effects, and potential for increasing resistance to antimicrobials. Continued research is needed to fill gaps in the current knowledge such as optimal preparation procedures for various surgical sites, standardization of efficacy and effectiveness testing, and the clinical impact of decreased susceptibility to chlorhexidine and other antiseptics.

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Evaluation of protocol change in burn‐care management using the Cox proportional hazards model with time‐dependent covariates

Ichida

Wassell

Keller

et al. 1993

Statistics in Medicine

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Survival analysis methods are valuable for detecting intervention effects because detailed information from patient records and sensitive outcome measures are used. The burn unit at a large university hospital replaced routine bathing with total body bathing using chlorhexidine gluconate for antimicrobial effect. A Cox proportional hazards model was used to analyse time from admission until either infection with Staphylococcus aureus or discharge for 155 patients, controlling for burn severity and two time-dependent covariates: days until first wound excision and days until first administration of prophylactic antibiotics. The risk of infection was 55 per cent higher in the historical control group, although not statistically significant. There was also some indication that early wound excision may be important as an infection-control measure for burn patients.

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Antimicrobial Activity of Chlorhexidine Gluconate Against Natural and Artificial Contamination During Simulation of in-use Conditions

Cited by 4 publications

References 5 publications

Clinical Evaluation of Local Drug Delivery of Chlorhexidine and Ornidazole in the Treatment of Gingivitis as an Adjunct to Scaling and Root Planing

Clinical Evaluation of Local Drug Delivery of Chlorhexidine and Ornidazole in the Treatment of Gingivitis as an Adjunct to Scaling and Root Planing

Small animal patient preoperative preparation: a review of common antiseptics, comparison studies, and resistance

Evaluation of protocol change in burn‐care management using the Cox proportional hazards model with time‐dependent covariates

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