Antimicrobial activity of ceftibuten/polymyxin B combination against polymyxin/carbapenem-resistant Klebsiella pneumoniae
Mariana Carvalho Sturaro,
Gleyce Hellen de Almeida de Souza,
Nathalia da Silva Damaceno
et al.
Abstract:Objectives
To evaluate the synergistic effect of a ceftibuten and polymyxin B combination and to determine its capacity to overcome polymyxin B resistance in polymyxin/carbapenem-resistant (PC-R) Klebsiella pneumoniae.
Methods
To investigate the combination’s antibacterial efficacy, antimicrobial susceptibility tests using broth microdilution methods, chequerboard assays and time–kill testing were performed. Antibiofilm activ… Show more
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