Antimicrobial activity of aqueous extracts of Larrea divaricata Cav (jarilla) against Helicobacter pylori

Stege, Patricia; Davicino, Roberto; Vega, Alba Edith; Casali, Yolanda; Correa, Silvia G.; Micalizzi, Blas

doi:10.1016/j.phymed.2005.06.008

Cited by 49 publications

(44 citation statements)

References 12 publications

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“…In addition, it is reported that, an aqueous extract from L. divaricata inhibits the growth of Helicobacter pylori; considering the low amount of NDGA, this effect was attributed to flavonoids content [46]. Also, antimicrobial activity against Gram-negative bacteria was demonstrated [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Antimicrobial Activities of Larrea Divaricata Cav. Aqueous Extract on Vitamin C from Natural Orange Juice

Micucci¹,

Alonso²,

Turner³

et al. 2011

FNS

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Antimicrobial Activities of Larrea Divaricata Cav. Aqueous Extract on Vitamin C from Natural Orange Juice

Micucci¹,

Alonso²,

Turner³

et al. 2011

FNS

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“…It is used in folk medicine for the treatment of many disorders since it has anti-inflammatory and antirheumatic properties [16] . The aqueous extract of its leaves has well-documented antitumoral and immunomodulatory activities [17,18] , antimicrobial properties [19,20] , and antioxidant activity demonstrated by peroxidase secretion of rat salivary glands [21] . Nordihydroguaiaretic acid (NDGA) has been identified as the major compound of L. divaricata leaves [22] .…”

Section: Introductionmentioning

confidence: 99%

Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR®

Alonso¹,

Anesini²

2017

Skin Pharmacol Physiol

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Background/Aims: Hair exerts protection, sensory functions, thermoregulation, and sexual attractiveness. Hair loss (alopecia) is caused by several diseases, drug intake, hormone imbalance, stress, and infections (Malassesia furfur). Drugs usually used in alopecia produce irreversible systemic and local side effects. An association of extracts of Coffea arabica and Larrea divaricata (ECOHAIR®) is successfully being commercialized in Argentina for hair growth. The aim of this study was to provide scientific support for the efficacy and innocuousness of ECOHAIR® in patients with noncicatricial alopecia during a 3-month treatment. Methods: The efficacy was determined through the assessment of an increase in hair volume, improvement in hair looks, growth of new hair, and a decrease in hair loss by the test of hair count and hair traction. The capacity to decrease the amount of dandruff was also evaluated as well as the adverse local effects caused by the treatment. Results: ECOHAIR® spray improved the overall hair volume and appearance; it increased its thickness, induced hair growth, and decreased hair loss. Besides, no adverse local reactions were observed upon treatment with the product. Conclusion: This study provides scientific support for the clinical use of ECOHAIR® as a treatment to be used in noncicatricial alopecia.

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“…Helicobacter pylori is a spiral-shaped bacterium that colonizes the stomach in 50% of the world's population (Stege et al, 2006). H. pylori infection is recognized as an important causative agent of gastroduodenal diseases, including chronic gastritis, peptic ulceration, gastric adenocarcinoma, and gastric lymphoma (Park et al, 2006;Ding et al, 2007;Wang et al, 2008;Pastene et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…However, this triple therapy is not always successful in eradicating the infection, and the acquisition of antibiotic resistance by H. pylori could reduce treatment efficacy and present a serious problem (Bonacorsi et al, 2009). As eradication therapies can be ineffective and undesirable side effects may occur, the search for new drugs for use in alternative therapies is very important (Stege et al, 2006;Zaidi et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes

Kitagawa¹,

Bonacorsi²,

Fonseca³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Helicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host immune cells (especially neutrophils) release inflammatory mediators and large amounts of reactive oxygen species (ROS), which are associated with an increased risk of developing gastric cancer. In this study, we evaluated the anti-H. pylori and antioxidant activities of a 1,4-naphthoquinone-5-methoxy-3,4-dehydroxanthomegnin. The antimicrobial activity was assessed using a spectrophotometric microdilution technique, and antioxidant activity was assessed by noting the effect of 5-methoxy-3,4-dehydroxanthomegnin on the neutrophil oxidative burst using luminol-and lucigenin-amplified chemiluminescence. The results showed that 5-methoxy-3,4-dehydroxanthomegnin is a potent anti-H. pylori compound (MIC 64 µg/mL and MBC 128 µg/mL) and a strong antioxidant. 5-Methoxy-3,4-dehydroxanthomegnin decreased luminol-and lucigenin-amplified chemiluminescence, with ED50 values of 1.58±0.09 µg/mL and 5.4±0.15 µg/mL, respectively, reflecting an inhibitory effect on the oxidative burst. These results indicate that 5-methoxy-3,4-dehydroxanthomegnin is a promising compound for the prevention and treatment of diseases caused by H. pylori infection, such as gastritis, peptic ulceration, and gastric cancer, because reactive oxygen intermediates are involved in the pathogenesis of gastric mucosal injury induced by H. pylori infections.

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Antimicrobial activity of aqueous extracts of Larrea divaricata Cav (jarilla) against Helicobacter pylori

Cited by 49 publications

References 12 publications

Antioxidant and Antimicrobial Activities of Larrea Divaricata Cav. Aqueous Extract on Vitamin C from Natural Orange Juice

Antioxidant and Antimicrobial Activities of Larrea Divaricata Cav. Aqueous Extract on Vitamin C from Natural Orange Juice

Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR®

Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes

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