Antimicrobial activity of antibiotic-soaked, Resist™-coated Bioflex®

Abstract

This study investigates whether a hydrophilic coating (Resistt), designed to inhibit bacterial adherence, applied to inflatable penile prostheses can prolong the effect of intraoperative antibiotics. The activity of antibiotic-soaked Bioflex s (penile prosthetic substrate material) discs with and without Resistt was examined by measuring the zone of inhibition following in vivo exposure in four groups of rabbits: 1, 2, 3 and 5 days' duration of disc implantation. Coated and uncoated discs were soaked in an aqueous solution of gentamicin and bacitracin. The implanted antibiotic-soaked discs were extracted, and the zone of inhibition against four microorganisms in vitro demonstrated that the Resistt coating was especially effective against Staphylococcus epidermidis, and statistically significant improvements were observed for the coated over the uncoated substrate up to 3 days following implantation. This effect, and the anti-adherence properties of Resistt, may prevent adhesion and colonization of some microorganisms to penile implants and reduce chances for infection.

Penile prosthesis coating and the reduction of postoperative infection

“…Previous experience using a similar coating on central venous catheters [47•] and hydrocephalic shunts [48] was positive. Hellstrom et al [49] investigated whether this hydrophilic coating (resist) applied to inflatable penile prostheses can prolong the effect of intraoperative antibiotics. The activity of the antibiotic-soaked Bioflex (penile prosthesis substrate material) discs with and without resist was examined by measuring the zone of inhibition following in vivo exposure in rabbits.…”

The role of biofilms in the genesis of infectious complications in penile prosthetic devices

“…Unlike the antibiotic coating, the hydrophilic gel is permanently bound to the prosthesis, and should not elute after a short time, perhaps enabling the prosthesis to be periodically recharged with antibiotics given by an oral or intravenous route. In vivo experiments have shown that the Resist coating prolongs antibiotic efficacy [75], but data on its bacterial antiadherence properties and clinical data are not yet available.…”

The Prevention and Treatment of Penile Prosthesis Infections

“…This coating absorbs surgeon chosen intraoperative antibiotics that can elute into surrounding tissues over 24-72 h to further decrease infection (Hellstrom et al, 2003). Mansouri and colleagues compared the spectrum and durability, both in vitro and in vivo of the hydrophilic coated prosthesis dipped in vancomycin and the InhibiZone implants, and found that the antibiotic pre-impregnated prosthesis had a broader spectrum in vitro and a more durable antimicrobial activity in vitro and in an animal model than implants dipped in vancomycin (Mansouri et al 2009).…”