Antimicrobial activity of Alstonia macrophylla: a folklore of bay islands

Chattopadhyay, Debprasad; Maiti, K; Kundu, Anish; Chakraborty, M.; Bhadra, Rupak K.; Mandal, Subash C; Mandal, Asit Baran

doi:10.1016/s0378-8741(01)00264-1

Cited by 76 publications

(59 citation statements)

References 7 publications

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“…The ethanolic extract from the stem of L. pacari showed MIC values of 625 μg/mL for all strains of S. aureus. These values (Table 2) (Fabry et al, 1998), whilst values ranging 64 -1000 μg/mL against bacteria, and 32 -128 μg/mL against dermatophytes, were reported for Alstonia macrophylla (Chattopadhyay et al, 2001 (Koné et al, 2004), and extracts of Quercus infectoria and Punica granatum were highly effective against Escherichia coli (O157:H7) with MIC values of 90 and 190 μg/mL, respectively (Voravuthikunchai et al, 2004).…”

Section: Resultsmentioning

confidence: 72%

“…The observed antibiotic activity against S. aureus (32-2000 μg/mL) of the leaf extract of Alstonia macrophylla has been attributed to the presence of ursolic acid together with other minor components (Chattopadhyay et al, 2001). The antibiotic activity of the condensed tannins, catechin and epicatechin has been previously demonstrated by Esquinazi et al (2002).…”

Section: Resultsmentioning

confidence: 73%

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The antibiotic activity of some Brazilian medicinal plants

Lima¹,

Ximenes²,

Luna³

et al. 2006

Rev. bras. farmacogn.

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Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 73%

The antibiotic activity of some Brazilian medicinal plants

Lima¹,

Ximenes²,

Luna³

et al. 2006

Rev. bras. farmacogn.

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“…However, previous chemical analysis of the adult plants extracts of collect 1 (25), indicated the presence of flavonoids, steroids and saponins. Some of these compounds have been shows antimicrobial activity as reported by Chattopadhyay et al (6) and Pena et al (21).…”

Section: Discussionmentioning

confidence: 81%

Comparative study of antibacterial and antifugal activity of callus culture and adult plants extracts from Alternanthera maritima (Amaranthaceae)

Salvador¹,

Pereira²,

França³

et al. 2004

Braz. J. Microbiol.

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The aim of this study was to evaluate the antibacterial and antifungal activity of callus culture (two different hormonal combination culture medium) and adult plants (two collect) extracts from Alternanthera maritima (Amaranthaceae) investigating the maintenance of antimicrobial activity in vivo and in vitro. The antibacterial and antifungal activity was determined by the agar-well diffusion method against thirty strains of microorganisms including Gram-positive and Gram-negative bacteria, yeasts and dermatophytes. All the organic crude extracts studied were bioactive. Extracts of aerial parts and roots of adult plants collected during the same period of years of 1995 and 1998 (Restinga de Maricá (RJ), collect 1 and 2) inhibited the growth of several microorganisms (bacteria, yeasts and dermatophytes) with inhibition halo between 6 and 20 mm. Plant cell callus culture extracts obtained from two culture conditions were also bioactive. Thus, the positive results suggest that the A. maritima extracts should be further studied to determine the bioactive chemical compounds as well as to understand the possible mechanisms of action and evaluate their toxicity looking toward a pharmaceutical employment.

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“…The extract was collected in a 5L conical flask, filtered and the solvent was evaporated in vacuo to a residue by a Eyela Rotary Evaporator (Japan) at 40 -45°C, with an yield of 7.8 ± 0.2% (w/ w). A part of the residue was stored in a dessicator for further study (Chattopadhyay et al, 2001(Chattopadhyay et al, , 2003(Chattopadhyay et al, , 2006. The phytochemical analysis (Trease and Evans, 1983;Arunachalam et al, 2002;Chattopadhyay et al, 2004) indicated the presence of tannins, flavonoids, triterpenoids, sterols, alkaloids and reducing sugars.…”

Section: Extraction and Fractionationmentioning

confidence: 99%

“…study with few such medicaments showed promising results (Chattopadhyay et al, 1998;Chattopadhyay et al, 2001;Arunachalam et al, 2002;Chattopadhyay et al, 2002). The Genus Ophiorrhiza, sister group of Rubioideae of the family Rubiaceae contain 47 species (Manen and Natali, 1996), of which O. infundibularis Balakr., O. mungos L, O. nicobarica Balakr.…”

mentioning

confidence: 99%

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Chattopadhyay¹,

Das²,

Mandal³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYThis study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholic extract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine of Nicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated the analgesic and antiinflammatory potential of this herb in acute, subacute and chronic model of inflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivity and membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests are used as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema was used as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellateinduced granuloma as chronic inflammatory model. The probable mode by which ON mediate its effect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membrane stabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dose dependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/ kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibit membrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed to hypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extract was nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We have isolated ursolic acid, β-sitosterol and harmaline respectively, from the bioactive part of the extract. The results indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that its anti-inflammatory activity may not be related to membrane-stabilization.

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Antimicrobial activity of Alstonia macrophylla: a folklore of bay islands

Cited by 76 publications

References 7 publications

The antibiotic activity of some Brazilian medicinal plants

The antibiotic activity of some Brazilian medicinal plants

Comparative study of antibacterial and antifugal activity of callus culture and adult plants extracts from Alternanthera maritima (Amaranthaceae)

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

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